A5101936536- Antifungal resistance and susceptibility
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Cancer therapeutics and mechanisms
- Immunotherapy and Immune Responses
- Lignin and Wood Chemistry
- Biofuel production and bioconversion
- Click Chemistry and Applications
- Fungal Infections and Studies
- Musculoskeletal pain and rehabilitation
- RNA and protein synthesis mechanisms
- Parasites and Host Interactions
- Bacteriophages and microbial interactions
- Parasite Biology and Host Interactions
- Immune Cell Function and Interaction
- Enzyme-mediated dye degradation
- Helminth infection and control
- Bacterial Genetics and Biotechnology
- Microbial Metabolic Engineering and Bioproduction
- Fermentation and Sensory Analysis
- Inflammatory mediators and NSAID effects
- Microbial Natural Products and Biosynthesis
- Healthcare and Venom Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Tianjin University of Science and Technology
2025
Beijing University of Chemical Technology
2016-2025
National Institute for Parasitic Diseases
2023-2025
China Academy of Chinese Medical Sciences
2025
Zhengzhou University
2024
Southeast University
2024
Dalian Medical University
2023-2024
Taizhou People's Hospital
2024
Nantong University
2024
Summary Toll‐like receptors (TLR) are sentinel capable of recognizing pathogen‐associated molecule patterns (PAMP) such as lipopolysaccharide (LPS) and CpG‐containing oligonucleotides (CpG ODN). TLR2 TLR4 major for Gram‐positive Gram‐negative bacterial cell wall components, respectively. TLR9 is necessary CpG signalling. LPS or ODN can activate immature dendritic cells (DC) induce DC maturation characterized by production cytokines, up‐regulation co‐stimulatory molecules, increased ability...
Malonyl-CoA is the rate-limiting precursor involved in chain elongation reaction of a range value-added pharmaceuticals and biofuels. Development malonyl-CoA responsive sensors holds great promise overcoming critical pathway limitations optimizing production titers yields. By incorporating Bacillus subtilis trans-regulatory protein FapR cis-regulatory element fapO, we constructed hybrid promoter–regulatory system that responds to broad intracellular concentrations (from 0.1 1.1 nmol/mgDW)...
Patients' satisfaction with an appointment system when they attempt to book a nonurgent is affected by their ability doctor of choice and at convenient time day. For medical conditions requiring urgent attention, patients want quick access familiar physician. such instances, it important for clinics have open slots that allow same-day (urgent) access. A major challenge designing outpatient systems the difficulty matching randomly arriving patients' booking requests physicians' available in...
Injectable self-healing hydrogel dressings with excellent elasticity and multifunctional repair effects have been in high demand wound healing applications, while maintaining stable injectable is still a challenge. Based on carboxymethyl chitosan (CMCS), curcumin-gelatin nanoparticles (CG NPs), sodium alginate oxide (OSA), we developed double-crosslinking elastic without any chemical cross-linking agent as dressing. CG NPs were more than pure curcumin (Cur) could regulate the of hydrogels...
Emerging advancements in large language models (LLMs) show significant potential for enhancing recommendations. However, prompt-based methods often struggle to find ideal prompts without task-specific feedback, while fine-tuning-based are hindered by high computational demands and dependence on open-source backbones. To address these challenges, we propose a Reflective Reinforcement Large Language Model (Re2LLM) session-based recommendation, which refines LLMs generate utilize specialized...
TNF-alpha-related apoptosis-inducing ligand (TRAIL) is characterized by its preferential induction of apoptosis tumor cells but not normal cells. Dendritic (DCs), besides their role as APCs, now have been demonstrated to exert cytotoxicity or cytostasis on some Here, we report that both human CD34(+) stem cell-derived DCs (CD34DCs) and CD14(+) monocyte-derived (MoDCs) express TRAIL exhibit types partially through TRAIL. Moderate expression appeared CD34DCs from the 8th day culture was also...
Cryptococcus neoformans is one of the most important causes life-threatening fungal infections in immunocompromised patients. Lanosterol 14 alpha-demethylase (CYP51) target azole antifungal agents. This study describes, for first time, 3-dimensional model CYP51 from (CnCYP51). The was further refined by energy minimization and molecular-dynamics simulations. active site CnCYP51 well characterized multiple-copy simultaneous-search calculations, four functional regions rational drug design...
The production of reactive oxygen species (ROS) is a ubiquitous defense response in plants. Adapted pathogens evolved mechanisms to counteract the deleterious effects host-derived ROS and promote infection. How plant regulate this elaborate against burst remains unclear. Using rice blast fungus Magnaporthe oryzae, we uncovered self-balancing circuit controlling planta virulence. During infection, induces phosphorylation high osmolarity glycerol pathway kinase MoOsm1 its nuclear...
Enhancement of lignin reactivity plays a critical role in the chemical modification lignin. In current study, simple, green, and effective method, ozone oxidation, was developed to improve enzymatic through formation carboxyl groups. The resultant ozonate (OzEL) indicated higher esterification. ozonated grafted polyethylene glycol (OzEL-PEGs) afforded satisfactory water solubility, good surface activity, emulsifying properties. remaining phenolic hydroxyl groups OzEL-PEGs also maintain...
Precise and efficient regulation of microglia is vital for ischemic stroke therapy prognosis. The infiltration neutrophils into the brain provides opportunities regulatory drugs across blood-brain barrier, while hindered by neutrophil extracellular traps (NETs) targeted delivery intracerebral to microglia. This study reports an hijacking nanoplatform (referred as APTS) A151 (a telomerase repeat sequence) without generation NETs. In middle cerebral artery occlusion (MCAO) mouse model,...
Flowery-like aroma are positive contributors to green tea. Here, the optimal processing conditions for tea with flowery-like were designed using spreading time, fixation time and drying temperature as three factors by response surface methodology (RSM), value of sensory evaluation score. The volatiles in batches samples analyzed GC–MS. quality was obtained a RSM under 8.97 h, 162.3 s, 103.32 °C. GC-O odor activity values further revealed floral-like volatiles, including decanal, linalool...