A5036173353- Mast cells and histamine
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Inflammasome and immune disorders
- Microfluidic and Capillary Electrophoresis Applications
- Polyamine Metabolism and Applications
- Antibiotics Pharmacokinetics and Efficacy
- High Altitude and Hypoxia
- Heme Oxygenase-1 and Carbon Monoxide
- Amino Acid Enzymes and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Biochemical Analysis and Sensing Techniques
- Analytical Methods in Pharmaceuticals
- Pharmacy and Medical Practices
- Bacteriophages and microbial interactions
- Neuroscience of respiration and sleep
- Traditional Chinese Medicine Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
Guangdong Pharmaceutical University
2025
General Hospital of Shenyang Military Region
2012-2024
Tongren Hospital
2024
Shanghai Jiao Tong University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
Beijing Municipal Health Bureau
2022
Jinzhou Medical University
2022
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
Infections of Helicobacter pylori (H. pylori) affect 42.1 % the Chinese population and 43.1 world population. H. inhabits mucous sublayer at pylorus, leading to gastric ulcers, gastritis, even cancer. Oral antibiotics are usually used treat infections, whereas traditional quadruple therapy has side effects including headaches, nausea, diarrhea, intestinal dysbacteriosis, antibiotic resistance, repeat infections. Here, a drug-loaded magnetic microbullet was designed realize long-term...
Abstract It is recognized that IL‐18 related to development of asthma, but role in asthma remains controversial and confusing. This largely due lack information on expression binding protein (BP) receptor (R) asthma. In this study, we found plasma levels IL‐18BP were elevated The ratio between concentrations was 1:12.8 patients. We demonstrated 13‐fold more monocytes, 17.5‐fold neutrophils 4.1‐fold B cells express than asthmatic blood, suggesting there excessive amount abolish actions also...
Per a 9 is major allergen of the American cockroach (CR), which has been recognized as an important cause imunoglobulin E-mediated type I hypersensitivity worldwide. However, it not neasy to obtain substantial quantity this for use in functional studies. In present study, gene was cloned and expressed Escherichia coli (E. coli) systems. It found that 13/16 (81.3%) sera from patients with allergies caused by CR reacted 9, assessed enzyme-linked immunosorbent assay, confirming CR. The...
Aim: Multicenter study to investigate the safety of mite extract product Novo-Helisen Depot, Strengths 1 3 (NHD3), as subcutaneous immunotherapy (SCIT), in Chinese children and adolescents with allergic rhinitis (AR) asthma (AA). Patients & methods: We evaluated SCIT-related adverse events (AEs) during NHD3 14-week initial therapy (5–11 years) (12–17 perennial symptomatic AR AA. Results: Among 3600 injections 250 patients, 361/3600 (10.0%) caused AEs 96/250 (38.4%) 321/3600 (8.9%) local...
Hyperuricemia frequently accompanies dyslipidemia, yet the precise mechanism remains elusive. Leveraging cellular metabolomics analyses, this research probes potential mechanisms wherein hyperuricemia provokes endothelial cell abnormalities, inducing disordered bile metabolism and resultant lipid anomalies.
Abstract Background Patients with major depressive disorder (MDD) have an increased risk of breast cancer (BC), implying that these two diseases share similar pathological mechanisms. This study aimed to identify the key pathogenic genes lead occurrence both triple-negative (TNBC) and MDD. Methods Public datasets GSE65194 GSE98793 were analyzed differentially expressed (DEGs) shared by datasets. A protein-protein interaction (PPI) network was constructed using STRING Cytoscape PPI cytoHubba....
AIM:To investigate the ability of agonists PAR-2 to stimulate release tryptase and histamine from human colon mast cells potential mechanisms. METHODS:Enzymatically dispersed colons were challenged with tc-LIGRLO, tc-OLRGIL, SLIGKV, VKGILS, trypsin, anti-IgE or calcium ionophore A23187, cell supernatants after challenge collected.Tryptase was determined a sandwich ELISA procedure measured using glass fibrebased fluorometric assay. RESULTS:Both tc-LIGRLO-NH 2 SLIGKV-NH able induce dose...
High altitude environments cause the human body to undergo a series of pathological, physiological and biochemical changes, which have certain effect on drug pharmacokinetics. The objective present study was observe changes in factors affecting pharmacokinetics rats following acute exposure high return low altitude. A total 21 male Wistar were randomly assigned three groups. group maintained at Shanghai, 55 m above sea level; those B acutely exposed Maqu, Gansu, 4,010 C then returned Blood...
Abstract Background Large numbers of CD8 + T cells were observed in atopic dermatitis (AD) skin, and monocytes from AD patients showed increased prostaglandin E2 production. However, little is known about the expression substance P (SP) its receptor NK1R blood leukocytes with AD. Objective To explore SP influence allergens on expression. Methods The levels examined by flow cytometry, ELISA a mouse model. Results plasma level was 4.9-fold higher than HC subjects. Both percentage population...
Cross-priming amplification (CPA) was evaluated for the early detection of norovirus (NV), rotavirus A (RV-A), enteric adenovirus (EAdV) and astrovirus (AstV). The analytical sensitivity CPA assay 10(3) copies ml(-1) NV, RV-A AstV 10(4) EAdV detection. For each four pathogens, positive rate by similar to real-time PCR methods higher than observed in an ELISA. coincidence rates RT-PCR RV-A, were 98, 99, 99 100%, respectively. All assays negative 89 healthy control samples. These results...
Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in plasma of individuals with various diseases. However, the role LRG1 allergic airway disease not investigated.To explore involvement allergy and its cell origins.The expression levels receptor transforming growth factor-beta II (TGFBR2) patients rhinitis (AR) asthma (AS) were examined by flow cytometry, enzyme-linked immunosorbent assay (ELISA).LRG1 soluble TGFBR2 AR AS markedly lower than that healthy control (HC) subjects....
IL-18 has been found to be associated with eczema. However, little is known of the role binding protein (BP) and receptor (R) in We therefore investigated expression IL-18, IL-18BP, IL-18R on mast cells by using flow cytometry analysis mouse eczema model. The results showed that plasma free IL-18BP levels patients were higher than those healthy controls. provoked up 3.1-fold increase skin cells. induced also an IL-18BP+ cells, but a reduction IL-18R+ skin. It was house dust mite allergen Der...
IL-18 is likely to contribute asthma. However, little known regarding the role of binding protein (BP) and receptor (R) in Because action body regulated by IL-18BP mast cells basophils are key cell types involved asthma, we investigated expression IL-18, IL-18R using flow cytometry a mouse asthma model. We found that among basophils, approximately 53% 51% were IL-18+ , 85% 81% IL-18BP+ 19.8% 8.6% IL-18R+ healthy control (HC) asthmatic blood, respectively. The allergens tested had effect on...
Interleukin- (IL-) 18 and tryptase were previously reported to relate asthma, but the correlation between these two potent proinflammatory molecules in asthma their roles mast cell accumulation remain uninvestigated. Using flow cytometric analysis technique ovalbumin- (OVA-) sensitized mouse model, it was found that IL-18 levels plasma of moderate severe elevated, they correlated well with each other. Tryptase agonist peptides protease activated receptor- (PAR-) 2 induced substantial...