A5067962033- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- Sinusitis and nasal conditions
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Respiratory and Cough-Related Research
- Nasal Surgery and Airway Studies
- Dermatology and Skin Diseases
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Genomic variations and chromosomal abnormalities
- IL-33, ST2, and ILC Pathways
- Air Quality and Health Impacts
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Obstructive Sleep Apnea Research
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
Central South University
2016-2025
Third Xiangya Hospital
2016-2025
University of California, Davis
2003-2006
Third Hospital of Changsha
2002
The prevalence of sensitization in patients with asthma and rhinitis mainland China remains unclear.Our aim was to estimate the allergy respiratory allergic diseases such as and/or attending clinics within China. study also investigated regional annual differences pattern among China.A cross-sectional survey performed 6304 suffering from 17 cities 4 regions Patients completed a standardized questionnaire asking for presence symptoms. They underwent skin prick tests 13 common...
The association between sensitizations and severity of allergic diseases is controversial.
<h3>Objective</h3>To evaluate the long-term efficacy of bilateral endoscopic vidian neurectomy in management moderate to severe persistent allergic rhinitis.<h3>Design</h3>A prospective reassessment postoperative results using Rhinoconjunctivitis Quality Life Questionnaire and visual analog scale for patients with rhinitis.<h3>Setting</h3>University hospital.<h3>Patients</h3>A total 236 rhinitis were divided into following 3 treatment groups: those who underwent (group 1, n = 93), partial...
The ability of the 10-23 DNAzyme to specifically cleave RNA with high efficiency has fuelled expectation that this agent may have useful applications for targeted therapy. Here, we, first time, investigated antitumor and radiosensitizing effects a (DZ1) Epstein-Barr virus (EBV)-LMP1 mRNA nasopharyngeal carcinoma (NPC) in patients. Preclinical studies indicated was safe well tolerated. A randomized double-blind clinical study conducted 40 NPC patients who received DZ1 or saline...
Inherited deficiency of the mitochondrial protein frataxin causes neural and cardiac cell degeneration, Friedreich's ataxia. Five hypotheses for frataxin's function have been generated, largely from work in non-human cells: iron transporter, iron-sulfur cluster assembler, iron-storage protein, antioxidant stimulator oxidative phosphorylation. We analyzed gene expression three human types using microarrays, identified just 48 transcripts whose was significantly frataxin-dependent at least two...
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
Abstract Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For purpose exploring roles dysregulated long non-coding RNA (lncRNA) NPC, we identified a novel lncRNA LINC00669 apparent negative correlation to overall survival human NPC mRNA expression profiling databases. We further performed pulldown coupled mass spectrum find out its target protein, applied series vitro vivo...
To investigate the prevalence of allergic rhinitis among elementary and middle school students examine its impact on their quality life.Stratified sampling cluster surveys were performed 10-17-year-old in Changsha city from June 2011 to April 2012.In stratified survey, self-reported rate was 42.5 per cent. Further examination demonstrated that average 19.4 The survey 214 814 appeared be atopic (26.3 cent). asthma 17.2 2.1 cent, respectively. In total, 71 individuals (8.7 cent) without any...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide with high morbidity mortality. However, diagnosis molecular mechanisms of HNSCC remains poor. Methods Robust rank aggregation method was performed to excavate differentially expressed genes (DEGs) in five datasets (GSE6631, GSE13601, GSE23036, GSE30784, GSE107591) from Gene Expression Omnibus. Search Tool for Retrieval Interacting Genes (STRING) database extracted hub...
The latest research findings on bidirectional regulation of neuro-immunity through traditional neural circuits shed new light the theoretical basis role vidian neurectomy (VN). This article aims to provide a comprehensive understanding VN, including history principle neuroimmuno-interaction, applied anatomy VN as well methods transnasal endoscopic surgery. Additionally, we introduce concept nose-brain axis, which was proposed based advancement in area neuro-immune interactions.
Lactate, traditionally viewed as a byproduct of glycolysis, is increasingly recognized pivotal regulatory factor in cancer biology. This study addresses the limited understanding lactate metabolism-related genes head and neck squamous cell carcinoma (HNSC) by constructing prognostic risk model centered on these to enhance prediction treatment strategies for HNSC. Utilizing Lactate Metabolism score (LMs) derived from The Cancer Genome Atlas (TCGA), we identified five key significantly...
Background Allergen sensitization is influenced by genetic and environmental factors; however, the factors related to sensitizations in patients with rhinitis asthma China are largely unknown. This study investigated associated allergen China. Methods A cross-sectional survey was performed 6304 and/or from four regions of Patients completed a standardized questionnaire respiratory allergic symptoms, family history diseases, smoking history, exposure, eating behaviors. They underwent...
Hemorrhage within the ethmoid and/or sphenoid sinus and an interval between time of injury operation exceeding 3 days are risk factors for visual prognosis traumatic blindness.To investigate therapeutic efficacy endoscopic optic nerve decompression in treatment blindness to evaluate relevant prognostic factors.Eighty-five cases were analyzed retrospectively. Univariate analysis multiple logistic regression performed potential factors.The overall rate vision acuity improvement was 44.7% (38...
Conclusion: Our results indicate that vidian neurectomy may be recommended as an effective method for the treatment of vasomotor rhinitis (VMR). Objective: The aim this work was to study feasibility and effectiveness under nasal endoscope VMR. Methods: included 45 patients with They were all assigned functional endoscopic surgery neurectomy. Results: obtained data showed that, using rhinoconjunctivitis quality life questionnaire, relieved symptoms VMR in 82.2% patients. Vidian also led...
miRNAs play a crucial role in regulating immune responses. However, the effect of miR-124-3p on type 2 inflammation allergic rhinitis (AR) is unclear. We aimed to study regulation AR and mechanisms involved.The direct interaction between IL-4Rα was confirmed through dual-luciferase reporter assay. In vitro splenic lymphocytes from mice peripheral blood mononuclear cells (PBMCs) healthy individuals were cultured treated with mimic/inhibitor. Twenty-four female C57BL/C divided into four...
The immune system plays a crucial role in initiating, progressing, and disseminating HNSCC. This study aims to investigate the differences microenvironments between 2D-4-culture 3D-4-culture models of head neck squamous cell carcinoma (HNSCC) cells (FaDu), human fibroblasts (HF), monocytes (THP-1), endothelial (HUVEC). For model, FaDu:HF:THP-1 (2:1:1) were inoculated an ultra-low attachment culture plate, while HUVECs placed transwell chamber. ordinary plate was used for model....
Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase cell cycle and trigger apoptosis. To investigate apoptosis induced paclitaxel nasopharyngeal carcinoma (NPC), possible molecular mechanism action, human NPC lines HNE-1 (bearing wild-type p53) CNE-2 mutant were treated with different concentrations paclitaxel. Apoptosis was determined staining propidium iodide also DNA fragmentation. Protein expression levels p53, bcl-2 bcl-xl...
Background The prevalence of both allergic rhinitis and bronchial asthma is high throughout the world; their mutual influence on each other has been documented in many studies. However, studies regarding surgical intervention are limited. Objective To evaluate clinical significance endoscopic vidian neurectomy outcomes patients with coexisting refractory asthma. Methods A total 109 moderate to severe persistent intractable mild/moderate were allocated bilateral group (group 1) or...