A5037209779- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Toxin Mechanisms and Immunotoxins
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Heat shock proteins research
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- Apelin-related biomedical research
Hunan Cancer Hospital
2017-2025
Central South University
2016-2025
Zhuhai People's Hospital
2012-2024
Jinan University
2012-2024
Hunan University
2023-2024
Xiangya Hospital Central South University
2004-2023
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2023
The First Hospital of Changsha
2013
Jinan University
2012
University of Minnesota
2006-2009
Abstract Insulin-like growth factor-I receptor (IGF-IR) has been implicated in cancer pathophysiology. Furthermore, impairment of IGF-IR signaling various cell lines caused inhibition the transformed phenotype as determined by colony formation soft agar and tumor athymic nude mice. Thus, might be an attractive target for prevention. We showed that tea polyphenol, (−)−epigallocatechin-3-gallate (EGCG), is a small-molecule inhibitor activity (IC50 14 μmol/L). EGCG abrogated...
Abstract The hepatitis B virus (HBV) is a major cause of human hepatocellular carcinoma (HCC) which has very high mortality rate due to incidence metastasis. It unknown whether HBV contributes HCC In this report, we present clinical data obtained from patients indicating that the expression X protein (HBx) in associated with an increased membrane‐type 1 matrix metalloproteinase (MT1‐MMP), and metalloproteinase‐2(MMP‐2), correlates poor prognosis. We further demonstrate experimentally HBx...
The ability of the 10-23 DNAzyme to specifically cleave RNA with high efficiency has fuelled expectation that this agent may have useful applications for targeted therapy. Here, we, first time, investigated antitumor and radiosensitizing effects a (DZ1) Epstein-Barr virus (EBV)-LMP1 mRNA nasopharyngeal carcinoma (NPC) in patients. Preclinical studies indicated was safe well tolerated. A randomized double-blind clinical study conducted 40 NPC patients who received DZ1 or saline...
Abstract Background Ezrin is highly expressed in skin cancer and promotes tumor metastasis. serves as a promising target for anti-metastasis therapy. The aim of this study to determine if the flavonoid bacailein inhibits metastasis cells through Ezrin. Methods Cells from cutaneous squamous carcinoma cell line, A431, were treated with baicalein at 0-60 μM establish non-cytotoxic concentration (NCC) range baicalein. Following treatment within range, total protein (both phosphorylated...
Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) associated with lung adenocarcinoma. However, its pathological role non-small cell (NSCLC) remains unknown. In our study we investigated LINC81507 NSCLC. The expression was analyzed 105...
Nasopharyngeal carcinoma (NPC) is a malignant tumor that highly prevalent in Southeast China, and its metastasis remains an unresolved clinical problem.Ferroptosis, type of nonapoptotic cell death, critical pathway metastasis.Berberine (BBR), plant alkaloid, has been explored as potential anti-NPC metastatic agent; however, the underlying mechanisms are unknown.Here, we showed BBR exerted anti-metastasis role by inhibiting system Xc -/GSH/GPX4 axis-driven ferroptosis.The present study...
Abstract c-Jun is a component of the activator protein-1 (AP-1) complex, which plays crucial role in regulation gene expression, cell proliferation, and transformation, as well cancer development. Herein, we found that cyclin-dependent kinase (Cdk)-3, but not Cdk2 or NH2-terminal kinase, novel induced by stimulation with growth factors such epidermal factor (EGF). Cdk3 was shown to phosphorylate at Ser63 Ser73 vitro ex vivo. EGF-induced activation caused phosphorylation Ser73, resulting...
The diagnostic and prognostic significance of increased cathepsin B (CTSB) D (CTSD) concentration in the serum cancer patients were evaluated for some tumor types. High expression CTSD CTSB was detected biopsy tissues from nasopharyngeal carcinoma (NPC). However, whether serve as markers NPC remains unclear.Serum samples collected 40 healthy volunteers 80 enrolled study. using enzyme-linked immunosorbent assay (ELISA). Concomitantly, relationship between concentrations clinicopathological...
// Jinping Lu 1,* , Zhen Lin Zhang Damao Huang 2,* Na Tang 3 Yuejin Li 1 Zhengke Peng Chengrong Zigang Dong 4 and Faqing 1,2 Clinical Laboratory Medical Research Center, Zhuhai Hospital of Jinan University, People's Hospital, Zhuhai, P.R. China 2 Laboratory, Xiangya Central South Changsha, Institution Pathogenic Biology, College, University China, Hengyang, Hormel Institute, Minnesota, Austin, USA * These authors have contributed equally to this work Correspondence to: Tang, email: Keywords...
Lung cancer is the most frequently diagnosed and main cause of death in world. X-box binding protein 1 (XBP1), which an important transcription factor involved regulating unfolded response (UPR) during endoplasmic reticulum (ER) stress, might act as a potent oncogenic processes tumorigenesis, tumor proliferation metastasis various cancers. However, clinical significance pathological role XBP1 non-small cell lung (NSCLC) remains unknown. In this study, we investigated expression XBP1s 104...
Nasopharyngeal carcinoma is a prevalent malignant tumor, which lacks specific diagnostic markers and effective therapeutic evaluation indexes. AGR2 (Pregradient protein 2) AKR1B10 (aldoketone reductase 1B10) are oncoproteins secreted by cancer cells into peripheral blood. Prior researches have suggested that the upregulation of occurs in both primary metastatic NPC tissues, indicating their potential as biomarkers for development. In present study, patients had considerably greater serum...
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha fusion gene (F/P) arising in the pluripotent hematopoietic stem cell (HSC),causes 14% to 60% of patients with hypereosinophilia syndrome (HES). These patients, classified as having F/P (+) chronic eosinophilic leukemia (CEL), present clonal eosinophilia and display a more aggressive disease phenotype than (-) HES patients. mechanisms underlying predominant eosinophil lineage targeting cytotoxicity eosinophils this remain...
Cancer therapy targeting programmed death receptor-1 (PD-1 or CD279) death-ligand 1 (PD-L1 CD274) gives hope to Tongue Squamous Cell Carcinoma (TSCC) treatment. However, the tumor-intrinsic mechanism of PD-L1 is not fully elucidated in TSCC. On other hand, lycopene showed antitumor effects and chemotherapy/radiotherapy-enhancing by mechanisms closely correlated with PD-L1. We aimed explore whether signaling regulation are reversible treatment collected TSCC tissues normal for assessment...
As a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics. However, the functions and mechanisms by which circRNAs exert protective in non-small cell lung cancer (NSCLC) remain largely elusive. The prognostic role circGUCY1A2 was explored adenocarcinoma specimens. overexpressed knockdown plasmids were used evaluate effect on NSCLC proliferation apoptosis efficacy. Luciferase reporter system is prove that could...