A5049487134- Cancer-related Molecular Pathways
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Breast Cancer Treatment Studies
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Circular RNAs in diseases
- HIV Research and Treatment
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Bone health and treatments
Hunan Normal University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
China West Normal University
2025
Chang'an University
2024
Ministry of Water Resources of the People's Republic of China
2024
Jishou University
2021
The University of Texas Health Science Center at Houston
2009-2019
GTx (United States)
2014-2017
Hunan University
2016
Central South University
2002-2013
Abstract BACKGROUND Hematopoietic cells home to bone by means of chemo‐attraction marrow chemokines, and interaction chemokines with their receptors leads the expression/activation adhesion molecules proteases. Recent evidence suggests that similar mechanisms may be active in cancer metastasis. Previously, we showed metalloproteases (MMPs), particular MMP‐9, play a role prostate (PC) expansion bone. METHODS We used variety methods including RT‐PCR, immunohistochemistry, ELISA, gelatin...
Background: Clinical studies have shown that resuscitation with fresh frozen plasma (FFP) is associated improved outcome after severe hemorrhagic shock (HS). We hypothesized in addition to its effects on hemostasis, FFP has protective and stabilizing the endothelium translate into diminished endothelial cell (EC) permeability vivo HS. further beneficial of would diminish over 5 days routine storage at 4°C. Methods: EC was induced by hypoxia assessed passage 70-kDa Dextran between monolayers....
Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes morbidity and mortality worldwide.Despite progress in treatment, there still an urgent need to discover novel therapeutic agents for NSCLC.Natural products represent a rich source bioactive compounds.Through natural compound library screening assay, we found that group anti-insect drugs had significant inhibitory effect on proliferation NSCLC cells.Among drugs, two derivatives artemisinin, i.e., artesunate (ART)...
microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development malignant behaviors. Accumulating evidence suggests miR-675-5p plays important roles in human carcinogenesis. However, its precise biological role remains largely elusive. This study examined non- cell lung cancer (NSCLC). The expression was analyzed real-time quantitative PCR (qRT-PCR). effect on proliferation evaluated through MTT and...
Scope In this study, the anti-inflammatory effects and molecular mechanism of alliin were analyzed in dextran sulfate sodium (DSS)-induced colitis mice lipopolysaccharide-stimulated RAW264.7 cell model. Methods The phenotype was recorded DSS-induced and/or (500 mg/kg) groups. Histopathological alterations by H&E staining. MPO MDA colon tissues measured. mRNA expression levels inflammatory factors determined qRT-PCR, protein expressions or activation kinases Western blotting. Results Oral...
Despite advances in the treatment of breast cancer, disease continues to exhibit high global morbidity and mortality.The importance neutrophils cancer development has been increasingly recognized.Neutrophil extracellular traps (NETs) are web-like structures released into space by activated neutrophils, serving as a potential antimicrobial mechanism for capturing eliminating microorganisms.The roles played NETs have subject intense research last decade.In current evidence suggests that...
Background After major traumatic injury, patients often require multiple transfusions of fresh frozen plasma ( FFP ) to correct coagulopathy and reduce bleeding. A spray‐dried SDP product has several logistical benefits over use in trauma with coagulopathy. These include ease transport, stability at room temperature, rapid reconstitution for infusion. Our past work suggests that promotes endothelial by inhibiting permeability. Study Design Methods The main goal this project is determine if...
The latent membrane protein 1 (LMP1), which is encoded by the Epstein-Barr virus (EBV), an important oncogenic that closely related to carcinogenesis and metastasis of nasopharyngeal carcinoma (NPC), a prevalent cancer in China. We previously reported expression functional chemokine receptor CXCR4 associated with human NPC metastasis. In this study, we show LMP1 induces tyrosine sulfation through tyrosylprotein sulfotransferase-1 (TPST-1), enzyme responsible for catalysis vivo, likely...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy occurring at high incidence in Southeast Asia and southern China.In spite of the good response to radio-and chemo-therapy early stage, resistance recurrence develop NPC patients advanced setting.Cancer stem cells (CSCs) play important role drug cancer recurrence.Here we report that lovastatin, a natural compound lipophilic statin has already been used clinic treat hypercholesterolemia, inhibited CSC properties...
Abstract Purpose: Chemokine receptors are implicated in metastasis of several malignant tumors. This study was done to evaluate the contribution chemokine CXCR4 and CCR7 human nasopharyngeal carcinoma. Experimental Design: Reverse transcription-PCR, immunohistochemistry, flow cytometry were used mRNA protein expression carcinoma tumor tissues cell lines. Chemotaxis assays function cells. Antisense inhibit receptor block cells vivo athymic mice. Results: detected 31 40 primary 13 15 lymph...