A5022235180- Immune cells in cancer
- Veterinary medicine and infectious diseases
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Eicosanoids and Hypertension Pharmacology
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Photodynamic Therapy Research Studies
- Axon Guidance and Neuronal Signaling
- Parasitic Infections and Diagnostics
- interferon and immune responses
- Toxoplasma gondii Research Studies
- Microbial Natural Products and Biosynthesis
- Long-Term Effects of COVID-19
- Cancer, Lipids, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Machine Learning in Materials Science
- Quinazolinone synthesis and applications
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
Chongqing Academy of Animal Science
2018-2024
Third Xiangya Hospital
2018-2023
Central South University
2017-2023
Second Xiangya Hospital of Central South University
2017-2023
University of Pittsburgh
2021
Background Sepsis is a syndrome with the disturbed host response to severe infection and major health problem worldwide. As front line of defense drug metabolism, liver vulnerable infection- or drug-induced injury. Acute injury (ALI) thus common in patients sepsis significantly associated poor prognosis. However, there are still few targeted drugs for treatment this clinics. Recent studies have reported that mesenchymal stem cells (MSCs) show potential various diseases, while molecular...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy occurring at high incidence in Southeast Asia and southern China.In spite of the good response to radio-and chemo-therapy early stage, resistance recurrence develop NPC patients advanced setting.Cancer stem cells (CSCs) play important role drug cancer recurrence.Here we report that lovastatin, a natural compound lipophilic statin has already been used clinic treat hypercholesterolemia, inhibited CSC properties...
BackgroundPyroptosis, gasdermin-mediated programmed cell death, is readily induced in macrophages by activation of the canonical inflammasome (caspase-1) or intracellular lipopolysaccharide (LPS)-mediated non-canonical (caspase-11) activation. However, whether pyroptosis similarly hepatocytes still largely controversial but highly relevant to liver pathologies such as alcoholic/nonalcoholic disease, drug-induced injury, ischemia-reperfusion and transplant organ damage secondary...
Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative dysfunction. Maresin 1 (MaR1), pro-resolving lipid mediator, has been shown suppress I/R injury. However, the mechanisms that account for protective effects of MaR1 in remain unknown. WT (C57BL/6J) mice were subjected partial hepatic warm ischemia 60mins followed by reperfusion. Mice treated with (5-20 ng/mouse), Boc2 (Lipoxin A4 receptor antagonist), LY294002 (Akt...
Multiple organ perfusion is impaired in sepsis. Clinical studies suggest that persistent disturbances are prognostic of fatal outcome Pyroptosis occurs upon activation caspases and their subsequent cleavage gasdermin D (Gsdmd), resulting Gsdmd-N (activated NH2-terminal fragment Gsdmd) form membrane pores to induce cell death In addition, Gsdmd-/- mice protected from a lethal dose lipopolysaccharide (LPS). However, how Gsdmd-mediated pyroptosis endothelial cells leads remain unexplored...
This paper introduces a multifaceted methodology for fine-tuning and evaluating large language models (LLMs) specialized monetization tasks. The goal is to balance general proficiency with domain-specific skills. has three main components: 1) Carefully blending in-domain general-purpose data during achieve an optimal between capabilities; 2) Designing comprehensive evaluation framework 45 questions tailored assess performance on functionally relevant dimensions like reliability, consistency,...
Colorectal cancer (CRC) is the third most common around world.
To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize series of novel pleuromutilin derivatives containing cinnamic acid scaffold at C-14 side chain. We evaluated their antibacterial activity and in silico docking study binding mode with target. The structure-activity relationship (SAR) suggested that compounds NO2 (13e), OH (13u), NH2 (13y) appeared more active (0.0625-2 µg/mL) vitro against several penicillin-resistant Gram-positive...
Coronavirus disease 2019 (COVID-19) emerged as a global pandemic and resulted in significantly high death toll. Therefore, there is an urgent need to find potential biomarker related the severity that can facilitate early-stage intervention.In present study, we collected 242 laboratory-confirmed COVID-19-infected patients. The patients were grouped according alveolar arterial oxygen tension difference (PA-aO2) value of COVID-19 infection after admission.Among COVID-19- infected patients, 155...
Abstract Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative dysfunction. Maresin 1 (MaR1), pro-resolving lipid mediator, has been shown suppress I/R injury. However, the mechanisms that account for protective effects of MaR1 in remain unknown. Methods WT (C57BL/6) mice were subjected partial hepatic warm ischemia 60mins followed by reperfusion. Mice treated with (5-20ng/mouse), Boc2 (Lipoxin A4 receptor...
Toxoplasmosis post serious threaten to human health, leading severely eye and brain disease, especially for immunocompromised patients pregnant women. The multiple side effects long dosing period of current main treatment regiments calls high effective low toxicity anti-toxoplasmosis drugs. Herein, we report our efforts synthesize a series 2-(piperazin-1-yl)quinazolin-4(3H)-one derivatives investigate their activity against Toxoplasma gondii tachyzoites in vitro based on cell phenotype...
Abstract A series of new febrifugine derivatives with a 4(3 H )‐quinazolinone scaffold were synthesized and evaluated for their anticoccidial activity both in vitro vivo. The targets' against Eimeria tenella was studied using quantitative real‐time reverse transcription polymerase chain reaction Madin‐Darby bovine kidney cells. Most these compounds demonstrated efficacy, inhibition ratios ranging from 3.3% to 85.7%. Specifically, 33 34 showed significant inhibitory effects on the...
Hemorrhagic shock with tissue trauma (HS/T) leads to the activation of a system-wide immune-inflammatory response that involves all organs and body compartments. Recent advances in single-cell analysis permit simultaneous assessment transcriptomic patterns large number cells making it feasible survey landscape immune cell responses across numerous anatomic sites. Here, we used RNA sequencing leukocytes from blood, liver, spleen identify major shifts gene expression by type compartment mouse...
Colorectal cancer (CRC) is one of the major killer diseases worldwide, and more effective therapeutic compounds for CRC treatment are urgently needed.Although bioactive natural products derived from endophytic fungi have been extensively employed as antibiotics anticancer agents, little known about effect Rhytidhysteron sp.BZM-9 (an fungus)-derived on CRC.Herein, a molecule porric acid E was isolated sp.BZM-9.Alamar Blue cell viability assay, Western blotting, transmission electron...
Abstract Background : Interruption of hepatic blood inflow to reduce intraoperative loss during liver surgery such as elective surgical procedures and organ transplantation causes ischemia subsequent reperfusion that leads damage dysfunction. Double-stranded RNA dependent protein kinase (PKR) is an important regulator immune responses in the settings infection tissue injury. However, little known about function PKR ischemia/reperfusion (I/R) Methods Wild-type (WT) knockout (PKR -/- ) mice...