A5101874639- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Dermatological and COVID-19 studies
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Pneumonia and Respiratory Infections
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Dysphagia Assessment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Chronic Kidney Disease and Diabetes
- Climate Change and Health Impacts
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
Hunan Provincial Center for Disease Control and Prevention
2024
University of Pittsburgh
2021
Abstract Background Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients diagnosed as mild early may progress to severe cases. However, it is difficult distinguish these in the stage. The present study aimed describe clinical characteristics patients, analyze related factors, and explore predictive markers aggravation. Methods laboratory data nonsevere adult COVID-19 Changsha, China, were collected analyzed on admission. A logistic regression model was...
Abstract Background The purpose of the study is to describe blood lipid levels patients diagnosed with coronavirus disease 2019 (COVID-19) and analyze correlation between prognosis COVID-19 patients. Methods In clinical retrospective analysis, a total 228 adults infected were enrolled January 17, 2020 March 14, 2020, in Changsha, China. One thousand one hundred forty healthy participants matched age gender used as control. Median interquartile range Mann-Whitney test adopted data....
Background Coronavirus disease 2019 (COVID-19) has been shown to affect almost every organ throughout the body. However, it is not clear whether thyroid gland impaired in COVID-19 patients. Euthyroid sick syndrome (ESS) usually associated with severity and deterioration prognosis critical illness. In this study, function of patients was assessed factors outcomes were analyzed determine potential predictive value ESS. Methods Clinical laboratory data or without ESS Changsha, China, collected...
Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, disease 2019 (COVID-19), affecting more than seventeen million people around world. Diagnosis and treatment guidelines for clinicians caring patients are needed. In early stage, we have issued “A rapid advice guideline diagnosis (2019-nCoV) infected pneumonia (standard version)”; now there many direct evidences emerged may change some previous recommendations it ripe...
Sepsis is a lethal and complex clinical syndrome caused by infection or suspected infection. Cold-inducible RNA-binding protein (CIRP) widely distributed cold-shock that plays proinflammatory role in sepsis may induce organ damage. However, studies regarding the use of CIRP for prognostic evaluation are lacking. The purpose this research was to investigate significance peripheral blood concentrations sepsis. assessed using several common measures, including Acute Physiology Chronic Health...
COVID-19 patients may experience "cytokine storm" when human immune system produces excessive cytokines/chemokines. However, it remains unclear whether early responses of inflammatory cytokines would lead to high or low titers anti-SARS-CoV-2 antibodies.
Trauma is the leading cause of death and disability for individuals under age 55. Many severely injured trauma patients experience complicated clinical courses despite appropriate initial therapy. We sought to identify novel circulating metabolomic signatures associated with outcomes following trauma.Untargeted metabolomics plasma immune mediator analysis was performed on collected during 3 post-injury time periods (<6 hours [h], 6 h-24h, day 2-day 5) in critically ill enrolled between April...
Background: The epidemiological and clinical characteristics of corona virus disease 2019 (COVID-19) patients in the cities near to Wuhan remain not very clear. Methods: data COVID-19 hospitalized Public Health Treatment Center Changsha, China were collected analyzed. Findings: Of 242 with COVID-19, median age was 45 years old (range, 1-84 years) 50.8% women. 41.3% had a exposure history, which one Huanan seafood market history. Three medical staff infected, only doctor's infection deemed be...
Objective Association of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) use with coronavirus disease 2019 (COVID-19) remains controversial. We aimed to investigate the impact ACEI/ARB on all-cause mortality in severe COVID-19 patients hypertension. Methods enrolled 650 from Changsha and Wuhan city between 17 January 2020 8 March 2020. Demographic, clinical characteristics, outcomes were collected. Multivariable analysis propensity-score matching...
Coronavirus disease 2019 (COVID-19) pandemic has caused substantial threats to people's physical health and lives, claiming the lives of over 6 million people worldwide. Although mortality rate COVID-19 is very low, many survivors may have different degrees various sequelae. Previous studies shown that pulmonary fibrosis (PF) were common on discharged patients, PF itself a poor prognostic factor.227 hospitalized patients' clinical laboratory data from first 15 days following admission...
Background Cigarette smoking has been proven to be a risk factor in the development of many diseases. However, it remains controversial with respect relationship COVID-19. The purpose this study was explore role Methods A total 622 patients COVID-19 China were enrolled study. Corresponding clinical and laboratory data collected analyzed. Meanwhile, Kaplan-Meier curve Cox regression analysis employed analyze association survival Results Smoking statistically significant comparing...
Triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-c) is crucial when researching metabolic and vascular diseases, its involvement in COVID-19 was sparsely elaborated on. The purpose of the study explore inflammatory associations between TG/HDL-c prognosis.A total 262 patients consisting 244 survivors 18 non-survivors were retrospectively investigated. clinical features baseline hematological parameters recorded analyzed. receiver operating characteristic curve (ROC) used...
The coronavirus disease 2019 (COVID-19) pandemic has caused substantial threats to people's physical health and lives, claiming the lives of over 5 million people worldwide. It is imperative identify severity intervene with effective therapy as early possible. Previous studies have shown that low free triiodothyronine (FT3) may possess predictive value on COVID-19 prognosis.In this retrospective cohort study, 15-day clinical laboratory data 186 hospitalized patients after admission were...
Aim: Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients did not show fever. However, the difference between clinical characteristics fevered and non-fevered is still unclear. The aim present study was to describe these analyze predictors for severe events adult COVID-19 patients. Methods: laboratory data in Changsha, China, were collected analyzed. Logistic regression analysis Receiver Operating Characteristic Curve (ROC Curve) adopted risk factors...
OBJECTIVES To investigate the clinical characteristics and risk factors for severe events of coronavirus disease 2019 (COVID-19) in elderly patients. METHODS Retrospective analysis was performed on data all COVID- 19 patients treated Changsha Public Health Treatment Center from January 17, 2020 to March 15, 2020, which included basic diseases, symptoms, test results, other characteristics, prognostic indicators such as severity illness, length hospital stay, virus shedding time mortality...
Background Nowadays, there is still no effective treatment developed for COVID-19, and early identification supportive therapies are essential in reducing the morbidity mortality of COVID-19. This first study to evaluate D-dimer lymphocyte ratio (DLR) as a prognostic utility patients with Methods We retrospectively analyzed 611 separated them into groups survivors non-survivors. The area under curve (AUC) various predictors integrated prognosis COVID-19 was compared using receiver operating...
Coronavirus disease 2019 (COVID-19) emerged as a global pandemic and resulted in significantly high death toll. Therefore, there is an urgent need to find potential biomarker related the severity that can facilitate early-stage intervention.In present study, we collected 242 laboratory-confirmed COVID-19-infected patients. The patients were grouped according alveolar arterial oxygen tension difference (PA-aO2) value of COVID-19 infection after admission.Among COVID-19- infected patients, 155...
Acute kidney injury (AKI) is a frequent complication of sepsis and contributes to increased mortality. Discovery reliable biomarkers could enable identification individuals with high AKI risk as well early detection progression monitoring. However, the current methods are insensitive nonspecific. This study aimed identify new through label-free mass spectrometry (MS) analysis model induced by cecal ligation puncture (CLP). Urine samples were collected from septic rats at 0, 3, 6, 12, 24, 48...
The worldwide epidemic of Coronavirus Disease 2019 (COVID-19) has evolved into multiple variants. Delta variant is known for its ability to spread and replicate, while data are limited about the virus shedding time in patients infected by variant.56 56 original SARS-CoV-2 from Hunan, China, matched according age gender divided two groups compared baseline characteristics laboratory findings with appropriate statistical methods.Patients had significantly fewer symptoms fever (p < 0.001),...
Abstract Background The aim of the present study was to describe clinical characteristics patients with different levels high-density lipoproteins (HDLs) and analyze correlation between HDL prognosis coronavirus disease 2019 (COVID-19) patients. Methods In retrospective analysis, a total 228 adult COVID-19 admitted Public Health Treatment Center Changsha, China from January 17 March 14, 2020 were enrolled. Median interquartile range Mann-Whitney test used depict Kaplan-Meier (KM) curve cox...
<title>Abstract</title> Background Lipid metabolism is particularly affected in response to acute infectious diseases caused by viruses, bacteria, or parasites. The association between levels of lipid profiles and mortality COVID-19 patients has become the subject increasing interest. Objective To evaluate predictive capacity dyslipidemia for based on dynamic data. Methods we conducted a retrospective, observational study, involving 135 admitted January 1 March 26, 2020. Results We found...