A5044238657- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Topic Modeling
- Natural Language Processing Techniques
- Melanoma and MAPK Pathways
- Bladder and Urothelial Cancer Treatments
- Multimodal Machine Learning Applications
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Urinary and Genital Oncology Studies
- Ion Channels and Receptors
- CRISPR and Genetic Engineering
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Redox biology and oxidative stress
- Advanced Image and Video Retrieval Techniques
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Human Pose and Action Recognition
- Kruppel-like factors research
- Genetics and Neurodevelopmental Disorders
- Circular RNAs in diseases
Shenzhen University Health Science Center
2016-2024
Lanzhou University
2020-2024
Lanzhou University Second Hospital
2020-2024
Shenzhen University
2014-2024
Institute of Archaeology
2024
Witten/Herdecke University
2024
Songjiang District Central Hospital
2024
Chinese University of Hong Kong
2023-2024
Amazon (United States)
2024
Bellevue Hospital Center
2024
Abstract Background Transfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs. Recent studies suggest that tRFs participate in some pathological processes. However, the biological functions and mechanisms non-small cell lung cancer (NSCLC) largely unknown. Methods Differentially expressed were identified by tRF tiRNA sequencing using 9 pairs pre- post-operation plasma from patients with NSCLC. Quantitative real-time PCR (qRT-PCR) fluorescence situ hybridization (FISH)...
Combining surface imprinting with nanomaterials is an effective solution to overcome template removal and achieve large binding capacity. In this work, highly monodisperse uniform-sized silica nanoparticles (NPs) average diameter of ∼400 nm were synthesized by using tetraethoxysilane (TEOS) as a single precursor, then vinyl groups introduced onto the NPs chemical modification γ-methacryloxypropyltrimethoxysilane (γ-MAPS). Subsequently, molecularly imprinted polymer (MIP) coating was...
Abstract Cross-lingual summarization is the task of generating a summary in one language (e.g., English) for given document(s) different Chinese). Under globalization background, this has attracted increasing attention computational linguistics community. Nevertheless, there still remains lack comprehensive review task. Therefore, we present first systematic critical on datasets, approaches, and challenges field. Specifically, carefully organize existing datasets approaches according to...
Abstract Insulin-like growth factor-I receptor (IGF-IR) has been implicated in cancer pathophysiology. Furthermore, impairment of IGF-IR signaling various cell lines caused inhibition the transformed phenotype as determined by colony formation soft agar and tumor athymic nude mice. Thus, might be an attractive target for prevention. We showed that tea polyphenol, (−)−epigallocatechin-3-gallate (EGCG), is a small-molecule inhibitor activity (IC50 14 μmol/L). EGCG abrogated...
Abstract The ribosomal S6 kinase 2 (RSK2), a member of the p90RSK (RSK) family proteins, is widely expressed serine/threonine that activated by extracellular signal-regulated 1/2 and phosphoinositide-dependent 1 in response to many growth factors peptide hormones. Its activation signaling enhances cell survival. However, roles RSK2 transformation have not yet been elucidated. Here, we found critical for regulation transformation. When cells were stimulated with tumor promoters, such as...
Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 widely expressed protein whose function might be critical in various nonneuronal physiologic conditions. The epidermal growth factor (EGFR) tyrosine kinase that overexpressed many human epithelial cancers and target for anticancer drugs. Here, we show interacts with EGFR, leading EGFR degradation. Notably, absence mice results striking...
While tick-borne zoonoses, such as Lyme disease and encephalitis, present an increasing global concern, knowledge of their vectors' distribution remains limited, especially for China. In this paper, we the first comprehensive dataset known tick species distributions in China, derived from peer-reviewed literature published between 1960 2017. We searched journal articles, conference papers degree thesis both English Chinese, extracted geographic information associated with occurrence, applied...
Abstract Solar UV irradiation is an important carcinogen that leads to the development of skin cancer, which most common human cancer. However, receptors mediate UV-induced carcinogenesis have not yet been unequivocally identified. Here we showed directly activates cannabinoid 1 and 2 (CB1/2). Notably, our data indicated absence CB1/2 in mice results a dramatic resistance UVB-induced inflammation marked decrease carcinogenesis. A attenuation activation mitogen-activated protein kinases...
MST1 (mammalian STE20-like kinase 1) is a serine/threonine that cleaved and activated by caspases during apoptosis. Overexpression of induces apoptotic morphological changes such as chromatin condensation, but the mechanism not clear. Here we show condensation through its phosphorylation histone H2AX at Ser-139. During etoposide-induced apoptosis in Jurkat cells, cleavage directly corresponded with strong phosphorylation. In vitro assay results showed strongly phosphorylates H2AX. Western...
We present ClidSum, a benchmark dataset towards building cross-lingual summarization systems on dialogue documents. It consists of 67k+ documents and 112k+ annotated summaries in different target languages. Based the proposed we introduce two settings for supervised semi-supervised scenarios, respectively. then build various baseline paradigms (pipeline end-to-end) conduct extensive experiments ClidSum to provide deeper analyses. Furthermore, propose mDialBART which extends mBART via further...
Jiaan Wang, Fandong Meng, Duo Zheng, Yunlong Liang, Zhixu Li, Jianfeng Qu, Jie Zhou. Proceedings of the 61st Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Development of reliable vectors is a major challenge in gene therapy. Previous transfer methods using non-viral vectors, such as liposomes or nanoparticles, have resulted relatively low levels (35∼ 50 %) expression. We developed silicon nanoparticle (SNAP) system, novel vector, for DNA into cells. SNAP was synthesized chemically and modified with sodium chloride iodide. Electronmicroscopy fluorescence microscopy fluorescence-labeled revealed that they were generated uniformly, had diameters...
Cyclin-dependent kinase (cdk)-3, a member of the cdk family kinases, plays critical role in cell cycle regulation and is involved G(0)-G(1) G(1)-S transitions. However, cdk3 proliferation, as well transformation, not yet clearly understood. Here, we report that protein expression level higher human cancer lines glioblastoma tissue compared with normal brain tissue. Furthermore, found phosphorylates activating transcription factor 1 (ATF1) at serine 63 enhances transactivation transcriptional...
Deubiquitinating enzymes (DUBs) negatively regulate protein ubiquitination and play an important role in diverse physiological processes, including mitotic division. The BRCC36 isopeptidase complex (BRISC) is a DUB that specific for lysine 63–linked ubiquitin hydrolysis; however, its biological function remains largely undefined. Here, we identify critical BRISC the control of spindle assembly cultured mammalian cells. microtubule (MT)-associated predominantly localizes to minus ends...
Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common major clinical challenge. RNF8 ubiquitin E3 ligase that plays essential roles in DNA damage response; however, its role pathogenesis cancer unclear. Here, we report overexpressed positively correlates with expression p-Akt poor survival patients non-small-cell cancer. In addition, identify as regulating activation Akt by K63-linked ubiquitination under physiological...
This paper proposes new methods and strategies for Multi-UAVs cooperative attacks with safety time constraints in a complex environment. Delaunay triangle is designed to construct map of the flight environment aerial vehicles. Delaunay-Map, Safe Flight Corridor (SFC), Relative (RSFC) are applied ensure each UAV trajectory's safety. By using such techniques, it possible avoid collision obstacles between UAVs. Bezier-curve further developed that multi-UAVs can simultaneously reach target at...
Abstract c-Jun is a component of the activator protein-1 (AP-1) complex, which plays crucial role in regulation gene expression, cell proliferation, and transformation, as well cancer development. Herein, we found that cyclin-dependent kinase (Cdk)-3, but not Cdk2 or NH2-terminal kinase, novel induced by stimulation with growth factors such epidermal factor (EGF). Cdk3 was shown to phosphorylate at Ser63 Ser73 vitro ex vivo. EGF-induced activation caused phosphorylation Ser73, resulting...
Abstract Extracellular signal-regulated kinase 8 (ERK8), a recently discovered member of the mitogen-activated protein family, has been less studied than other family members, leaving its physiologic functions mostly unknown. The biological consequences overexpression ERK8 in JB6 Cl41 epidermal skin cells or knockdown HCT15 colorectal cancer was studied. Kinase assays and transient transfection experiments were performed to study signaling pathway between c-Jun. We found that is relatively...
Various types of post-translational modifications the histone tails have been revealed, but a few found within core sequences. Histone potential to modulate nucleosome structure and DNA accessibility. Here, we studied H2B domain that phosphorylation serine 32 occurs in normal cycling mitogen-stimulated cells. Notably, this is elevated skin cancer cell lines tissues compared with counterparts. The JB6 Cl41 mouse epidermal line well established model for tumor promoter-induced transformation...