A5101497444- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience of respiration and sleep
- Drug-Induced Hepatotoxicity and Protection
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug Transport and Resistance Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Diet and metabolism studies
- Microfluidic and Capillary Electrophoresis Applications
- Neonatal Health and Biochemistry
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Cannabis and Cannabinoid Research
- Travel-related health issues
- Advanced Proteomics Techniques and Applications
- Pharmaceutical studies and practices
- Analytical Methods in Pharmaceuticals
Chinese People's Liberation Army
2019-2024
Ningxia Medical University
2019-2023
Lanzhou University
2013-2023
82th Hospital of Pla
2019-2023
Fujian Agriculture and Forestry University
2020
Zhongshan Hospital of Xiamen University
2020
81th Hospital of PLA
2020
Southwest Jiaotong University
2020
People's Liberation Army 401 Hospital
2019
Nanjing University
2018
Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics metabolism may be influenced microorganisms. If gut microbes are involved in of nifedipine, plateau hypoxia regulate bioavailability therapeutic effect nifedipine altering metabolic activity microbiota. We herein demonstrated for first time that flora vitro experiments. In addition, based on results 16S rRNA analysis feces rats after acute plateau, we confirmed environment could cause changes number...
This study aimed to explore the molecular regulatory network among microRNA-125b (miR-125b), forkhead box Q1 (FOXQ1), prostaglandin-endoperoxide synthase 2 (PTGS2), and cyclin-dependent kinase 5 (CDK5), as well their effects on cell apoptosis, neurite outgrowth, inflammation in Alzheimer disease (AD). Rat embryo cerebral cortex neurons nerve growth factor–stimulated PC12 cells were insulted by Aβ 1−42 construct two AD cellular models. Negative control (NC) inhibitor, miR-125b NC siRNA, FOXQ1...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Tofacitinib (CP‐690,550) is a novel, oral Janus kinase inhibitor being investigated as targeted immunomodulator and disease‐modifying therapy in rheumatoid arthritis. Non‐renal elimination accounts for 70% of the total clearance tofacitinib metabolism primarily mediated by cytochrome P450 (CYP) 3A4. This study was required to determine effect on vivo pharmacokinetics sensitive CYP3A4 substrate. STUDY ADDS The midazolam, substrate, are not altered...
An easy-to-handle magnetic dispersive solid-phase extraction procedure was developed for preconcentration and of cocaine metabolites in human urine. Divinyl benzene vinyl pyrrolidone functionalized silanized Fe3 O4 nanoparticles were synthesized used as adsorbents this procedure. Scanning electron microscopy, vibrating sample magnetometry, infrared spectroscopy employed to characterize the modified adsorbents. A high-performance liquid chromatography with mass spectrometry method...
Abstract Although extensive studies have focused on the development of acute mountain sickness (AMS), exact mechanisms AMS are still obscure. In this study, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis to identify novel AMS−associated biomarkers in human plasma. After 9 hours hypobaric hypoxia abundance proteins related tricarboxylic acid (TCA) cycle, glycolysis, ribosome, proteasome were significantly reduced resistant (AMS−) group, but not...
Pharmacodynamic and biodistribution effects are two important factors in drug research. As a clinical drug, the neuroprotective mechanisms of hydroxysafflor yellow A (HSYA) have been widely reported but still not described enough detail. In this study, we first aimed to improve pharmacology HSYA nerve injury treatments. The down-regulative expression cytokines, including NLRP3, ASC, Caspase-1, GSDMD, IL-1β, IL-18, LDH, NF-κB, p-p56, suggested that could both suppress pyroptosis apoptosis...
Extensive studies have been performed on acute mountain sickness (AMS), but biomarkers predicting AMS are lacking. Presently, the mainstay methods to identify include proteomic and genetic at high altitudes or in hypoxic simulated chambers. In present study, we compared plasma cytokine profiles between AMS-susceptible individuals AMS-resistant low altitude by array analysis. total, 75 differentially expressed cytokines were identified individuals, most involved inflammation. A quantifiable...
ABSTRACT The DNA fragment detection focusing technique has further enhanced the sensitivity and information of targets. method was established by capillary electrophoresis with laser‐induced fluorescence restriction endonuclease chromatographic fingerprinting (CE‐LIF‐REF) in our experiment. silica column coated short linear polyarclarylamide (SLPA) using nongel sieving technology. excision product various restricted enzymes fragments obtained REF molecular biology software Primer Premier 5....
Ulcerative colitis (UC) is a common chronic remitting disease but without satisfactory treatment. Maggots are known as traditional Chinese medicine named ‘wu gu chong’. The aim of the present study was to investigate therapeutic effect maggot protein on dextran sulphate sodium (DSS)-induced in C57BL/6 mice. In study, female mice were given sterile water containing 3% DSS establish model UC. Mice randomly divided into five groups: control group (sterile water), (DSS), treatment (DSS +...
High altitude environments cause the human body to undergo a series of pathological, physiological and biochemical changes, which have certain effect on drug pharmacokinetics. The objective present study was observe changes in factors affecting pharmacokinetics rats following acute exposure high return low altitude. A total 21 male Wistar were randomly assigned three groups. group maintained at Shanghai, 55 m above sea level; those B acutely exposed Maqu, Gansu, 4,010 C then returned Blood...
A direct large volume injection high-performance liquid chromatography (HPLC) method with homemade restricted-access media (RAM) pre-column and combined a column-switching valve was established developed for determination rifampicin (RIP) in rat plasma. The plasma samples (100 μL) were injected directly onto pre-column, where RIP retained pre-concentrated, while proteins washed to waste using methanol–water (5:95) as the mobile phase at flow rate of 1 mL/min. Then, by rotation switching 5...