A5088213883- Monoclonal and Polyclonal Antibodies Research
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Mechanisms of cancer metastasis
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- RNA regulation and disease
- Colorectal Cancer Treatments and Studies
- Alzheimer's disease research and treatments
- Catalytic Processes in Materials Science
- Retinal Development and Disorders
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Parkinson's Disease Mechanisms and Treatments
Southern Methodist University
2021-2025
Wenzhou Medical University
2011-2025
South China Agricultural University
2011-2025
Stanford University
2013-2024
Jinshan Hospital of Fudan University
2024
University of Hong Kong
2023-2024
Hong Kong University of Science and Technology
2023-2024
University of Shanghai for Science and Technology
2024
Methodist University
2024
Nanjing Forestry University
2022-2023
An ideal cancer therapeutic strategy is expected to possess potent ability not only ablate primary tumors but also prevent distance metastasis and relapse. In this study, human serum albumin was hybridized with hemoglobin by intermolecular disulfide bonds develop a hybrid protein oxygen nanocarrier chlorine e6 encapsulated (C@HPOC) for self-sufficient photodynamic therapy (PDT). C@HPOC realized the tumor-targeted co-delivery of photosensitizer oxygen, which remarkably relieved tumor hypoxia....
Abstract Metal complexes are widely used as anticancer drugs, while the severe side effects of traditional chemotherapy require new therapeutic modalities. Sonodynamic therapy (SDT) provides a significantly noninvasive ultrasound (US) treatment approach by activating sonosensitizers and initiating reactive oxygen species (ROS) to damage malignant tissues. In this work, three metal 4‐methylphenylporphyrin (TTP) (MnTTP, ZnTTP, TiOTTP) synthesized encapsulated with human serum albumin (HSA)...
Calcium (Ca2+) homeostasis is essential for neuronal function and survival. Altered Ca2+ has been consistently observed in neurological diseases. How achieved various cellular compartments of disease-relevant cell types not well understood. Here we show Drosophila Parkinson's disease (PD) models that transport from the endoplasmic reticulum (ER) to mitochondria through ER-mitochondria contact site (ERMCS) critically regulates mitochondrial (mito-Ca2+) dopaminergic (DA) neurons, PD-associated...
Hypoxia is a characteristic feature of solid tumors and an important causation resistance to chemotherapy photodynamic therapy (PDT).It challenging develop efficient functional nanomaterials for tumor oxygenation therapeutic applications.Methods: Through disulfide reconfiguration hybridize hemoglobin albumin, tumor-targeted hybrid protein oxygen carriers (HPOCs) were fabricated, serving as nanomedicines precise simultaneous enhancement hypoxia-dampened therapy.Based on encapsulation...
Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing human mutant (hTauR406W, or Tau∗), we show that zinc contributes the development of toxicity through two independent actions: by increasing phosphorylation and, more significantly, directly binding Tau. Elimination amino acid substitution Cys residues has minimal effect on levels yet essentially eliminates toxicity. The zinc-binding-deficient Tau∗ (Tau∗C2A) and overexpression native...
Oxidative and nitrosative damage are major contributors to cone cell death in retinitis pigmentosa (RP). In this study, we explored the effects of augmenting components endogenous antioxidant defense system models RP, rd1, rd10 mice. Unexpectedly, overexpression superoxide dismutase 1 (SOD1) rd1 mice increased oxidative accelerated death. With an elaborate mating scheme, genetically engineered with either inducible expression SOD2, Catalase, or both photoreceptor mitochondria were generated....
The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical signaling cooperates with a noncanonical pathway to mediate N-directed regulation. In the pathway, interacts PTEN-induced kinase 1 (PINK1) influence mitochondrial function, activating mechanistic target rapamycin complex 2 (mTORC2)/AKT Importantly, attenuating preferentially impaired...
T-cell-based therapies have emerged as one of the most clinically effective ways to target solid and non-solid tumors. HER2 is responsible for oncogenesis treatment resistance several human As a member HER family tyrosine kinase receptors, its over-activity confers unfavorable clinical outcome. Targeted directed at this receptor achieved responses, although development common. We explored novel HER2/CD3 bispecific antibody (HER2-BsAb) platform that while preserving anti-proliferative effects...
Significance Amyotrophic laterosclerosis (ALS) is a rapidly progressing neurological disease that robs patients’ motor functions. Despite intensive research, molecular events initiate the are poorly understood. Expansion of G4C2 repeats in C9orf72 gene causes ALS with frontotemporal dementia, one most common forms ALS. Increasing evidence suggests dipeptides translated from repeat transcripts, especially arginine-containing poly(GR) and poly(PR), particularly toxic. We found translation can...
Stimulator of IFN genes type I (STING-Type I) signaling in myeloid cells plays a critical role effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy clinical trials. The mechanisms that downregulate are not fully understood. Here, we report protein phosphatase 2A (PP2A), with its specific B regulatory subunit Striatin 4 (STRN4), negatively regulated STING-Type macrophages. Mice macrophage PP2A deficiency exhibited reduced tumor progression....
Lung cancer is the leading cause of cancer-related deaths. The morbidity and mortality lung have markedly increased in past decade with at least 75% patients having evidence metastases time diagnosis. It frequently metastasizes to bone resulting osteolytic lesions unknown mechanisms. aim this study was identify factors that mediate cancer–induced osteoclast activity vivo. Using a human cytokine antibody array, we first determined levels conditioned medium collected from non– small cell A549...
Pantothenate-Kinase-Associated-Neurodegeneration (PKAN) is a devastating disease, resulting from mutations in pantothenate kinase 2 ( PANK2) , one of the four human genes PANK1-4 ). Interestingly, PanK2 appears to be only mitochondria-targeted PanK. It unknown whether PanK associated with any unique function, nor PKAN due solely loss activity. Drosophila PANK [ fumble fbl )] encodes several isoforms products, which localizes mitochondria and others cytosol. flies exhibit many characteristic...
Amyotrophic lateral sclerosis (ALS) manifests pathological changes in motor neurons and various other cell types. Compared to neurons, the contribution of types ALS phenotypes is understudied. G4C2 repeat expansion C9ORF72 most common genetic cause along with frontotemporal dementia (C9-ALS/FTD), increasing evidence supporting repeat-encoded poly(GR) disease pathogenesis. Here, we show Drosophila muscle that enters mitochondria interacts components Mitochondrial Contact Site Cristae...