A5100780347- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Sperm and Testicular Function
- Ferroptosis and cancer prognosis
- Schizophrenia research and treatment
- Circular RNAs in diseases
- Pharmacological Effects of Natural Compounds
- Medical Imaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Protein Hydrolysis and Bioactive Peptides
- RNA regulation and disease
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Protease and Inhibitor Mechanisms
- Cellular Mechanics and Interactions
- Natural product bioactivities and synthesis
- Immune cells in cancer
- Ginseng Biological Effects and Applications
- interferon and immune responses
Amsterdam University Medical Centers
2024-2025
University of Amsterdam
2023-2025
Lanzhou University Second Hospital
2016-2025
Lanzhou University
2016-2025
Henan University
2025
Center for Life Sciences
2022-2024
Tsinghua University
2022-2024
Beijing University of Chinese Medicine
2024
Jiangyin People's Hospital
2021-2024
Southern Medical University
2023-2024
Postoperative progression and chemotherapy resistance is the major cause of treatment failure in patients with triple-negative breast cancer (TNBC). Currently, there a lack an ideal predictive model for drug sensitivity postoperative TNBC patients. Diverse programmed cell death (PCD) patterns play important role tumor progression, which has potential to be prognostic indicator after surgery.Twelve PCD (apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, entotic death, netotic...
Bacterial or viral infections, such as Brucella, mumps virus, herpes simplex and Zika destroy immune homeostasis of the testes, leading to spermatogenesis disorder infertility. Of note, recent research shows that SARS-CoV-2 can infect male gonads Sertoli Leydig cells, reproductive dysfunction. Due many side effects associated with antibiotic therapy, finding alternative treatments for inflammatory injury remains critical. Here, we found Dmrt1 plays an important role in regulating testicular...
Glioma is one of the highly fatal primary tumors in central nervous system. As a major component tumor microenvironment (TME), immune cell has been proved to play critical role progression and prognosis diffuse lower-grade gliomas (LGGs). This study aims screen key immune-related factors LGGs by investigating TCGA database.The RNA-sequencing data 508 LGG patients were downloaded database. ESTIMATE algorithm was utilized calculate stromal, immune, scores, based on which, differentially...
Objective: Apigenin is a natural flavonoid compound extracted from Matricaria chamomilla. We evaluated the anti-inflammatory effects of apigenin in this study using Lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods: cells were treated with for 1 h and then LPS. The inflammatory cytokine productions tested by qRT-PCR ELISA. expression GSK3β, Nrf2, NF-κB signaling pathways measured western blot analysis.Results: significantly attenuated LPS-induced TNF-α, IL-1β, IL-6 production....
Asymmetric synthesis of the pentacyclic alkaloid (-)-cephalotaxine was accomplished via palladium-catalyzed enantioselective Tsuji allylation for construction aza-containing tetrasubstituted stereogenic center (95% yield, 93% ee). The allyl enol carbonate precursor prepared from Hanaoka's ketone intermediate, which formed by a novel formic acid promoted ring-expansion reaction.
Objective: To identify the association between interleukin (IL) 6 (IL-6) rs1800795 (-174 G>C), IL-8 rs4073 (-251T>A), and matrix metalloproteinase-13 (MMP-13) rs2252070 (-77G>A) gene polymorphisms knee osteoarthritis (KOA) susceptibility in Chinese Han population. Methods: Genomic DNA was extracted from a total of 400 KOA patients healthy subjects. Sanger sequencing performed to determine genotypes IL-6 G/C), (-251A/T), MMP-13 (-77A/G) loci. The mRNA expression levels IL-6, IL-8, osteoblasts...
This study aimed to investigate the influence of CYP2D6 polymorphisms on risperidone plasma concentrations in patients with schizophrenia. Based pharmacogenomics, we examined whether concentration is associated clinical response and adverse side-effects.We recruited chronic schizophrenia who were then treated risperidone. The genotypes determined using targeted sequencing. All high-frequency mutation sites nine exons gene assayed present study. Plasma 9-hydroxyrisperidone (9-OH-RIS) measured...
Radiation therapy is a common treatment modality for lung cancer, and resistance to radiation can significantly affect outcomes. We recently described that cancer cells express more germ cell genes (GC genes, are usually restricted the line) repair DNA double-strand breaks rapidly, show higher rates of proliferation resistant ionizing than fewer GC genes. The gene encoding TRIP13 appeared play large role in this malignant phenotype. However, molecular regulatory mechanism remained largely...
The gut microbiome can modulate nutrient metabolism to produce many metabolites interacting with the host. However, intricate interactions among dietary intake, and metabolites, host need be further explored although some studies have been devoted it. Here, in a cross-sectional studies, 88 children aged 2–12 years were enrolled from northwestern China. intake data collected via designed food frequency questionnaire calculate plant-based diet indices (PDIs). Stool plasma samples for...
Myocardial ischemia-reperfusion injury (MIRI) remains an unsolved puzzle in medical circles. Naringenin (NAR) is a flavonoid with cardioprotective potential. The purpose of this article was to discuss the protective mechanism NAR MIRI by regulating macrophage polarization. mouse model established and perfused before surgery. In vitro experiment, macrophages RAW264.7 were treated lipopolysaccharide induce M1 polarization after pretreatment NAR. Rescue experiments carried out validate...
The aim of the study is to explore association serum bilirubin levels with admission severity and short term clinical outcomes among acute ischemic stroke patients.Data were collected from 2361 patients in four hospitals Shangdong Province during January 2006 December 2008. National Institutes Health Stroke Scale (NIHSS) was used assess discharge severity. NIHSS≥10 at or in-hospital death defined as short-term outcomes. Logistic regression trend test examine outcomes.Serum significantly...