A5100323074- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Thermochemical Biomass Conversion Processes
- Lignin and Wood Chemistry
- Metamaterials and Metasurfaces Applications
- Advanced Antenna and Metasurface Technologies
- Electromagnetic wave absorption materials
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- 2D Materials and Applications
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- Supercapacitor Materials and Fabrication
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- MXene and MAX Phase Materials
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Advanced ceramic materials synthesis
- Advanced Nanomaterials in Catalysis
- Advanced materials and composites
Wenzhou Medical University
2023-2025
Affiliated Eye Hospital of Wenzhou Medical College
2023-2025
Hebei University
2025
Southwest Petroleum University
2024-2025
Guangdong University of Technology
2021-2025
Shandong First Medical University
2022-2025
Shanghai Institute of Materia Medica
2025
Chinese Academy of Sciences
2025
State Key Laboratory of Drug Research
2025
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2025
N6-Methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on N6 nitrogen adenosine. However, roles m6A in oral squamous cell carcinoma (OSCC) are still elusive. Here, we investigate function and mechanism methyltransferase-like 3 (METTL3) OSCC tumorigenesis. Clinically, METTL3 was significantly upregulated tissue samples correlated with poor prognosis patients. Functionally, loss gain studies illustrated promoted proliferation,...
Exosomes derived from mesenchymal stem cells (MSCs) have been proven to exhibit great potentials in spinal cord injury (SCI) therapy. However, conventional two-dimensional (2D) culture will inevitably lead the loss of stemness MSCs, which substantially limits therapeutic potency MSCs exosomes (2D-Exo). three-dimensional (3D-Exo) possess higher efficiency wide applications Typically, exosome therapy that relies on local repeated injection results secondary and low efficiency. It is urgent...
Abstract Background A growing body of research shows that drug monomers from traditional Chinese herbal medicines have antineuroinflammatory and neuroprotective effects can significantly improve the recovery motor function after spinal cord injury (SCI). Here, we explore role molecular mechanisms Alpinetin on activating microglia‐mediated neuroinflammation neuronal apoptosis SCI. Methods Stimulation microglia with lipopolysaccharide (LPS) to simulate models in vitro, effect release...
Metal–organic frameworks (MOFs) have attracted much interest in electrocatalysis as promising catalysts recent years. However, it still remains a challenge to directly use MOF-based materials bifunctional electrocatalysts for overall water splitting. Herein, hierarchical Co,Fe-MOF-74/Co/carbon cloth (CC) three-layer hybrid electrode is synthesized by simple electrochemical deposition technology with subsequent solvothermal treatment. Electrochemical performance investigations show that the...
Abstract Effective neuroprotective agents are required to prevent neurological damage caused by reactive oxygen species (ROS) generated cerebral ischemia‐reperfusion injury (CIRI) following an acute ischemic stroke. Herein, it is aimed develop the of cerium oxide loaded with platinum clusters engineered modifications (Pt n ‐CeO 2 ). The density functional theory calculations show that Pt could effectively scavenge ROS, including hydroxyl radicals (·OH) and superoxide anions (·O − In...
<div>Abstract<p>Long-standing evidence implicates glioma stem cells (GSC) as the major driver for propagation and recurrence. GSCs have a distinctive metabolic landscape characterized by elevated glycolysis. Lactate accumulation resulting from enhanced glycolytic activity can drive lysine lactylation to regulate protein functions, suggesting that elucidating in could provide insights into biology. Herein, we demonstrated global was significantly compared with differentiated...
Cancer cells maintain energy metabolism mainly by glycolysis, even under sufficient oxygen conditions. It gives cancer better growth advantages complicated internal environment. KPNA2 is a novel oncogene that has received much attention in recent years, but the exact mechanisms of tumorigenesis and progression are largely unknown. Especially its potential roles metabolic transformation tumors still remain to be explored. The expressions glioblastoma normal human brain samples were analyzed...