A5100371662- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- RNA modifications and cancer
- CAR-T cell therapy research
- Renal Diseases and Glomerulopathies
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Thermochemical Biomass Conversion Processes
- Long-Term Effects of COVID-19
- Crystallography and molecular interactions
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Molecular Sensors and Ion Detection
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Photodynamic Therapy Research Studies
Icahn School of Medicine at Mount Sinai
2020-2025
Qingdao University
2013-2025
Allen Institute for Brain Science
2023-2025
University of Michigan
2021-2025
Hebei Medical University
2013-2025
The Ohio State University
2021-2025
Ontario Institute for Cancer Research
2021-2025
Affiliated Hospital of Qingdao University
2017-2025
Hunan University of Traditional Chinese Medicine
2025
Cancer Institute (WIA)
2025
There exist differences in the epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selections between gastric cancer patients from Eastern Western countries. The Chinese Society of Clinical Oncology (CSCO) has organized a panel senior experts specializing all sub-specialties to compile clinical guideline for diagnosis since 2016 renews it annually. Taking into account regional differences, giving full consideration accessibility...
Polymer-based room-temperature phosphorescence (RTP) materials with high flexibility and large-area producibility are highly promising for applications in organic electronics. However, achieving such photophysical is challenging because of difficulties populating stabilizing susceptible triplet excited states at room temperature. Herein large-area, flexible, transparent, long-lived RTP systems prepared by doping rationally selected chromophores a poly(vinyl alcohol) (PVA) matrix were...
The morphologic distinction between various serrated polyps of the colorectum may be challenging. sessile adenoma (SSA) and traditional (TSA) difficult using currently available criteria mostly based on cytologic characteristics. We have evaluated 66 including 29 SSA, 18 TSA, 19 hyperplastic for overall shape polyps, architectural features individual crypts, presence eosinophilic cytoplasm, size distribution proliferation maturation zones, as well Ki-67 CK20 expression. extent expression...
Dental caries and periodontal diseases have a close relationship with microbes such as Streptococcus mutans, Porphyromonas gingivalis Fusobacterium nucleatum. Graphene oxide (GO), the derivative of graphene, plays an important role in many areas including biology medicine. In particular, it has been known promising antimicrobial nanomaterial. this study, we focused on property GO against dental pathogens. With utilization 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT)...
Organic long-persistent luminescence (OLPL) materials have attracted wide attention on account of their fascinating properties, presenting application prospects in the fields bioimaging, information security, displays, anti-counterfeiting, and so on. Some effective strategies been developed to promote intersystem crossing (ISC) excited singlet state triplet limit nonradiative transition, thus OLPL with long lifetime (more than 1s) high quantum yield explored. However, dynamic...
ConspectusAfter decades of extensive fundamental studies and clinical trials, lipid nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna Pfizer-BioNTech vaccines fighting against COVID-19. Moreover, researchers clinicians been investigating therapeutics for a variety therapeutic indications including protein replacement therapy, genome editing, cancer immunotherapy. To realize these in clinic, there are many formidable challenges. First, novel systems LNPs with...
Gasdermin D (GSDMD) has been proved to be a key protein in the activation of pyroptosis. Pyroptosis renal tubular epithelial cells contributes progression injury kidney diseases. However, it remains elusive whether and how GSDMD involves regulation diabetic disease (DKD). In this study, we found that is accompanied by up-regulation Toll-like receptor 4 (TLR4) patients with disease. addition, discovered expressions cleaved Caspase-1, active N-terminal fragment (GSDMD-NT), IL-18 secretion...
Long-lived room temperature phosphorescence (RTP) materials are widely utilized in the field of biological and chemical sensing, due to their unique characteristics long-lived luminescence no background autofluorescence. However, realization full-color RTP aqueous solution still remains a great challenge. Herein, feasible strategy for achieving high stability carbon dots (CDs)-based composite environment is reported by constructing rigid hydrogen bonds' network. The obtained m,p-CDs@CA...
Abstract Materials exhibiting ultralong luminescent lifetime show promising applications in the fields of information encryption, sensing, and bioimaging. Herein, we present a low‐cost general strategy to achieve stimulus‐responsive organic phosphorescence (UOP) based on pyrene chromophores doped into polymer matrices. The UOP resulted systems presents radiation‐, concentration‐, time‐, excitation‐dependent characteristics. color can be turned from blue red by changing excitation wavelength...
Abstract Long‐lived room temperature phosphorescence (RTP) systems have become a research focus in the field of functional materials due to their fascinating luminescence properties. However, it is still an enormous challenge realize RTP under ambient conditions, since can be quenched easily by molecular oxygen. Herein, two polymer acceptors containing triphenyl phosphonium bromide salt are designed and synthesized successfully. They then doped into poly(methyl methacrylate) matrix with...
Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines has provided large-scale immune protection to the public. To elicit a robust response against SARS-CoV-2 infections, antigens produced by mRNAs encoding Spike glycoprotein need be efficiently delivered and presented antigen-presenting cells such as dendritic (DCs). As concurrent innate stimulation can facilitate antigen presentation process, library non-nucleotide STING agonist-derived amino lipids (SALs)...
Abstract Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic disorders, and autoimmune diseases. Currently, most cell products rely on ex vivo engineering, which requires sophisticated manufacturing processes poses safety concerns. The implementation in situ holds potential to overcome current limitations provides a broad range applications clinical feasibility future. A variety biomaterials have been developed improve function target delivery specific...
Abstract Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability promote tissue regeneration. However, limited repair capability has posed a challenge in achieving optimal outcomes. Herein, we conceive series of lipid nanoparticles reprogram ASCs with durable protein secretion capacity for enhanced engineering and In vitro studies identify that the isomannide-derived (DIM1T LNP) efficiently deliver RNAs ASCs. Co-delivery...
Advantages of rare earth-doped nanoparticles in second near-infrared fluorescence imaging and commonly used earth ions.
Current treatment options for diabetic wounds face challenges due to low efficacy, as well potential side effects and the necessity repetitive treatments. To address these issues, we report a formulation utilizing trisulfide-derived lipid nanoparticle (TS LNP)-mRNA therapy accelerate wound healing by repairing reprogramming microenvironment of wounds. A library reactive oxygen species (ROS)-responsive TS LNPs was designed developed encapsulate interleukin-4 (IL4) mRNA. TS2-IL4 LNP-mRNA...
RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that related to various disease processes, including malignant tumors. However, the biological functions methyltransferase-like 1 (METTL1)-regulated m7G in breast cancer (BC) remain largely obscure. The role METTL1 BC progression were examined by cellular loss- and gain-of-function tests xenograft models both vitro vivo. To investigate change modification mRNA translation efficiency BC,...
Androgen receptor (AR) is critical for prostate tumorigenesis and frequently overexpressed during cancer (PC) progression. However, few studies have addressed the epigenetic regulation of AR expression. We analyzed SMYD3 expression in human PC with Western blot immunohistochemistry. was knocked down using short hairpin RNA (shRNA) or small interfering (siRNA). Cell proliferation, colony formation, apoptosis analyses xenograft transplantation were performed to evaluate impact depletion on...
B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) plays an important role in regulating stemness some kinds of cancer. However, the mechanisms remain unclear. This study was to investigate whether and how Bmi-1 regulates gastric cancer.We firstly explored stem cell-like features Secondly, we screened out its downstream miRNAs clarified these are involved regulation stemness. Finally, investigated miRNAs.Bmi-1 positively properties cancer upregulates miR-21 miR-34a....
Industrial pollution and harmful chemicals seriously affect environment human health. Styrene is a common air toxicant with widespread exposure sources, including smoking, automobile exhaust, plastic pollutants. Phenylglyoxylic acid (PGA) typical biomarker for exposed styrene. Therefore, it crucial to quickly identify quantitatively detect PGA. Herein, an ultrastable terbium metal–organic framework (Tb-MOF 1) was developed, the luminescence film (1/PLA) consisting of polylactic (PLA) 1...