A5100617270- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Kidney Stones and Urolithiasis Treatments
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- Urinary and Genital Oncology Studies
- Proteoglycans and glycosaminoglycans research
- Cancer Research and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer-related gene regulation
Soochow University
2009-2025
Qinghai Institute for Endemic Diease Prevention and Control
2025
Jintan People's Hospital
2023-2025
Jiangsu University
2023-2025
First Affiliated Hospital of Bengbu Medical College
2024
Southern University of Science and Technology
2024
Qilu Hospital of Shandong University
2014-2023
Second Affiliated Hospital of Soochow University
2009-2023
Anhui Medical University
2020
First Affiliated Hospital of Anhui Medical University
2020
The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cells own higher malignance and exhibited increased metastatic ability, but the mechanism not clear. In this study, we investigated effects Ataxia Telangiectasia Mutated (ATM) on metastasis. A549CisR H157CisR cell line were generated by long-term treating parental A549 H157 (A549P H157P) with cisplatin. Cell growth, migration invasion determined. Gene expressions determined...
Renal cell carcinoma (RCC) is the most lethal type of genitourinary cancer due to its occult onset and resistance chemotherapy radiation. Recently, accumulating evidence has suggested stains, inhibitors 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, were associated with risk reduction cancer. In present study, we aimed investigate potential effects simvastatin on RCC cells underlying mechanisms by which exerted actions. With viability, colony formation, flow cytometric apoptosis...
Prostate cancer (PCa) is lethal type of genitourinary due to its high morbidity and gradual resistance androgen deprivation therapy. Accumulating evidence has recently suggested that the daily intake flavonoids negatively correlated with risk cancer. In this study, we aimed investigate potential effects baicalein on androgen-independent PCa cells underlying mechanisms through which exerts actions. Cell viability flow cytometric apoptosis assays indicated potently suppressed growth induced...
Androgen receptor (AR) is critical for prostate tumorigenesis and frequently overexpressed during cancer (PC) progression. However, few studies have addressed the epigenetic regulation of AR expression. We analyzed SMYD3 expression in human PC with Western blot immunohistochemistry. was knocked down using short hairpin RNA (shRNA) or small interfering (siRNA). Cell proliferation, colony formation, apoptosis analyses xenograft transplantation were performed to evaluate impact depletion on...
// Kun Wang 1, 2, * , Tiantian Liu 3, Nan Ge 4, Li 5 Xiaotian Yuan 2 Jikai 1 Feng Kong 4 Chang Hongbo Ren Keqiang Yan Sanyuan Hu 6 Zhonghua Xu Magnus Björkholm Yidong Fan Shengtian Zhao Cheng Dawei Department of Urology, Shandong University Qilu Hospital, Jinan, China Medicine, Division Hematology and Centre for Molecular Karolinska Hospital Solna Institutet, Stockholm, Sweden 3 Pathology, School Urology Central Research Laboratory, Second Nursing, General Surgery, These authors...
The prognosis of advanced non-small cell lung cancer (NSCLC) patients is poor. One the reasons for this hampered progress has been a lack in vitro models that would faithfully recapitulate heterogeneity tumors and response to treatment. In study, surgically resected were obtained from with stage I/II NSCLC during curative-intent surgery. Using 3D patient-derived tumor spheroids culture system, our results demonstrate successful long-term expansion primary cells (> 120 days). Patient-derived...
The aim of this study was to establish comprehensive and practical nomograms, based on significant clinicopathological parameters, for predicting the overall survival (OS) disease-specific (DSS) patients with clear cell renal carcinoma (ccRCC).The data 35,151 ccRCC patients, diagnosed between 2004 2014, were obtained from database Surveillance, Epidemiology, End Results (SEER) program. Kaplan-Meier method Cox proportional hazards regression model used evaluate prognostic effects multiple...
Abstract Renal cell carcinoma is the second malignant tumors in urinary system with high mortality and morbidity. Increasing evidence suggests that long non-coding RNAs (lncRNAs) play critical roles tumor development progression. In current study, based on publicly available data obtained from GEO TCGA database, we identified five prognosis-related lncRNAs ability to predict prognosis of patients renal carcinoma. Among them, uncharacterized upregulated lncRNA RCAT1 (renal cancer-associated...
Cancerous inhibitor of protein phosphatase 2A (CIP2A) drives cellular transformation. The objective this study was to detect the potential effects CIP2A in renal cell carcinomas (RCCs).A total 107 RCC patients were involved study. expression investigated by real-time PCR and immunohistochemistry. In vitro, we examined c-Myc tested migration invasion capability A498 KRC/Y cells with scratch assay Matrigel after down-regulating using siRNA.Cancerous over-expressed tissues. Clear showed an even...
BACKGROUND Bladder cancer (BC) is the most common urological malignant tumor. In BC, aberrant DNA methylation believed to be associated with carcinogenesis. Therefore, identification of key genes and pathways could help determine potential molecular mechanisms BC development. MATERIAL AND METHODS Microarray data on gene expression were downloaded from Gene Expression Omnibus (GEO) database. Abnormal methylated/expressed analyzed by GEO2R statistical software R. Ontology term enrichment Kyoto...
Hepatoma-derived growth factor (HDGF) is commonly over-expressed and plays critical roles in the development progression a variety of cancers. It has previously been shown that HDGF overregulated prostate cancer cells compared to normal cells, which correlated with cellular migration invasion cancer. Here, molecular mechanisms investigated. knockdown reduces both androgen-sensitive LNCaP androgen-insensitive DU145 PC3 cells. Furthermore, Western blot analysis reveals inhibits...
Increasing evidence indicates that the dysregulation of circular RNAs (circRNAs) plays important roles in tumor progressions.In this study, we first analyzed circ-FOXO3 level bladder cancers (BCs), and then BC cell lines were transfected with expression vector, proliferation, migration, invasion abilities analyzed. We also used bioinformatics tools to predict potential-binding miRNAs for circ-FOXO3, luciferase reporter assay was verification binding miRNAs. For further potential...
15-Lipoxygenase-1 (15-LOX-1) oxidizes polyunsaturated fatty acids to a rich spectrum of biologically active metabolites and is implicated in physiological membrane remodelling, inflammation apoptosis. Its deregulation involved the pathogenesis diverse cancer immune diseases. Recent experimental evidence reveals that dynamic histone methylation/demethylation mediated by methyltransferases demethylases plays critical role regulation chromatin remodelling gene expression. In present study, we...
Recent studies facilitated by DNA sequencing identified the histone modifying gene SETD2 as second most frequent mutant in sporadic clear cell renal carcinoma (ccRCC) patients. functions a tumor suppressor ccRCC. However, its clinical association and biological are not fully delineated. The aim of this study is to evaluate significance ccRCC canonical modification product H3K36me3 were analyzed immunohistochemistry (IHC) 155 patients from two independent cohorts retrospectively. Both...
Abstract The TERT promoter and FGFR3 gene mutations are two of the most common genetic events in urothelial bladder cancer (UBC), these mutation assays patient urine have been shown to be promising biomarkers for UBC diagnosis surveillance. These results were obtained mainly from studies patients with Western countries, little is known about such information Han Chinese UBC. In present study, we addressed this issue by analyzing tumors 182 samples 102 mRNA expression and/or urine. identified...
The present study examined the role of microRNA (miR)-96 in renal cell carcinoma (RCC) invasion. expression miR-96 was detected by quantitative reverse transcription-polymerase chain reaction human RCC lines with high (Caki-1) and low (786-O) metastatic potential. Invasive ability Ezrin were assessed Caki-1 786-O cells transfected a mimic or inhibitor using wound healing assays, Transwell assays western blotting. Expression also primary samples from 17 patients disease 46 who maintained...
Eukaryotic translation initiation factors (eIFs) constitute a new class of therapeutic cancer targets. EIF3b is the major scaffold protein eIF3 (the largest core eIFs). We sought to define role played by and mechanism action eIF3b in patients with clear cell renal carcinoma (ccRCC). found that high-level expression tumors was not only associated an aggressive tumor phenotype, but also independently prognostic for ccRCC. Knockdown impaired Akt pathway, thus inhibiting proliferation disrupting...
Although three therapeutic modalities (surgical resection, chemotherapy, and radiotherapy) have been established, long-term survival for lung cancer patients is still generally poor. Until now, the mechanisms of genesis remain elusive. The JARID1B a histone demethylase that has proposed as oncogene in several types human cancer, but its clinical significance functional role non-small cell (NSCLC) unclear. In present study, we found was overexpressed lines tissues not normal tissues....
Objective: To evaluate the value of serum sialic acid (SA) in diagnosis benign prostatic hyperplasia (BPH), prostate cancer (PCa), and bone metastases PCa patients.Materials Methods: Data from 540 patients who were newly diagnosed with or BPH between November 2014 March 2018 retrospectively collected analyzed.Pretreatment SA levels compared across various groups, then, associations clinic parameters analyzed as well.Univariate multivariate logistic regression analyses further used to...