A5008511216- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Celiac Disease Research and Management
- Colorectal Cancer Treatments and Studies
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Intestinal and Peritoneal Adhesions
- Esophageal Cancer Research and Treatment
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Innovations in Medical Education
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal motility and disorders
Western University
2014-2024
London Health Sciences Centre
2013-2024
University of Bern
2019
University Hospitals Bristol NHS Foundation Trust
2019
Mount Sinai Hospital
2019
Western University of Health Sciences
2019
Canadian Armed Forces
2011-2015
King Khalid University Hospital
2015
King Saud University
2015
Wilfrid Laurier University
2014
The morphologic distinction between various serrated polyps of the colorectum may be challenging. sessile adenoma (SSA) and traditional (TSA) difficult using currently available criteria mostly based on cytologic characteristics. We have evaluated 66 including 29 SSA, 18 TSA, 19 hyperplastic for overall shape polyps, architectural features individual crypts, presence eosinophilic cytoplasm, size distribution proliferation maturation zones, as well Ki-67 CK20 expression. extent expression...
<h3>Objective</h3> Although the Geboes score (GS) and modified Riley (MRS) are commonly used to evaluate histological disease activity in UC, their operating properties unknown. Accordingly, we developed an alternative instrument. <h3>Design</h3> Four pathologists scored 48 UC colon biopsies using GS, MRS a visual analogue scale global rating. Intra-rater inter-rater reliability for each index individual items were measured intraclass correlation coefficients (ICCs). Items with high develop...
Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug in the management of transplant recipients. Although gastrointestinal (GI) toxicity known complication MMF, literature characterizing pathologic features MMF GI tract sparse. This study characterizes both upper and lower tract, correlating it with clinical endoscopic findings. Seventy-five biopsies (9 esophageal, 15 gastric, 16 duodenal, 5 ileal, 30 colonic) from 46 recipients 2002 to 2006 were obtained assessed for...
Milan and University of California at San Francisco (UCSF) criteria are used to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT). Recurrent HCC is a significant cause death. There no widely accepted pathological assessment strategy predict recurrent after transplantation. This study compares the pathology meeting UCSF develops score nomogram assess risk All explanted livers from our center over 18-yr period 1985 2003 were assessed multiple features relevant...
In the multidisciplinary management of gastrointestinal stromal tumours (GISTs), there is a need to coordinate efforts pathology, radiology, surgery and oncology. Surgery mainstay for resectable nonmetastatic GISTs, but virtually all GISTs are associated with risk metastasis. Imatinib 400 mg/day or without recommended first-line treatment recurrent metastatic GIST; higher dose may be considered in patients who progress, develop secondary resistance present specific genotypic characteristics....
Venous invasion (VI) is an independent prognostic indicator in colorectal cancer and may prompt consideration for adjuvant chemotherapy patients with stage II tumors. Recent evidence suggests that VI underreported detection be enhanced by elastin stain. This study aimed (1) to determine the impact of stain on interobserver agreement between gastrointestinal (GI) non-GI pathologists, (2) identify factors associated increased detection. Forty hematoxylin eosin (H&E)-stained slides were...
Tumor budding is a well-established adverse prognostic factor in colorectal cancer. However, the significance and diagnostic reproducibility of pancreatic carcinoma requires further study. We aimed to assess tumor ductal adenocarcinoma, determine its relationship with other clinicopathologic features, interobserver variability diagnosis. was assessed 192 archival cases adenocarcinoma using hematoxylin eosin (H&E) sections; buds were defined as single cells or nonglandular clusters composed...
Histopathology is potentially an important outcome measure in UC. Multiple histological disease activity (HA) indices, including the Geboes score (GS) and modified Riley (MRS), have been developed; however, operating properties of these instruments are not clearly defined. We assessed reproducibility existing measures HA.Five experienced pathologists with GI pathology fellowship training expertise IBD evaluated, on three separate occasions at least two weeks apart, 49 UC colon biopsies...
Background. Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is clearest example clinically relevant oncogene mutation any human cancer. Methods. The incidence and significance amplification rhabdomyosarcoma (RMS) was assessed by Southern blot analysis this retrospective study seven alveolar RMS six embryonal RMS. Results. (4- to 13-fold) present three (42.9%)...
Collagenous colitis and lymphocytic (collectively known as microscopic colitis) are characterized by chronic diarrhea, normal endoscopic radiologic findings, typical findings on histologic examination of colonic tissue. The purpose this study was to define the background characteristics patients with colitis, well present symptoms, coexistent autoimmune diseases, a possible association use non-steroidal anti-inflammatory drugs (NSAIDs) ticlopidine.A retrospective chart review carried out all...
Granular cell tumours (GCTs) in the gastrointestinal (GI) tract are rare, with few series reported literature. Nestin is a recently identified intermediate filament protein that expressed neuroectodermal stem cells and skeletal muscle progenitor has been shown to be stromal (GISTs) GI schwannomas. Herein, we describe clinicopathological immunohistochemical features of 11 GCTs, introducing nestin as an additional marker identifies these tumours.The archives departments pathology at London...
The response of colorectal adenocarcinoma liver metastases to perioperative chemotherapy can be assessed histologically in partial hepatectomy specimens. Necrosis this scenario may represent a lack treatment effect or therapeutic chemotherapy. This study sought validate the histologic classification necrosis into 2 types: usual (UN) representing an absence effect, and infarct-like (ILN) Tumor regression grade (TRG) is previously described prognosticating method that estimates tumor...
Objective. Sessile serrated adenomas (SSAs) are precursors to colorectal cancer (CRC). The purpose of this study is determine the occurrence new polyps and CRC in patients with an SSA over a 5-year follow-up interval. Methods. This retrospective chart review SSAs diagnosed at colonoscopy 2005. Abstracted information included patient demographics, information, polyp characteristics. Results. During 2005, 34 5 mixed were identified 33 patients. mean age was 66 years 58% female. There family...