A5074819403- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Molecular Biology Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Cutaneous lymphoproliferative disorders research
- Hematological disorders and diagnostics
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Monoclonal and Polyclonal Antibodies Research
Royal University Hospital
2008-2025
University of Saskatchewan
2010-2025
Saskatchewan Health Authority
2018-2025
Saskatchewan Health
2019-2025
National Library of Luxembourg
2024
Saskatchewan Cancer Agency
2024
Princess Margaret Cancer Centre
2014-2021
University Health Network
2011-2021
University of Toronto
2011-2019
Lung Institute
2019
To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone (PgR) testing in breast cancer utility these receptors as predictive markers.
Serrated lesions of the colorectum are precursors perhaps one-third colorectal cancers (CRCs). Cancers arising in serrated usually proximal colon, and account for a disproportionate fraction cancer identified after colonoscopy. We sought to provide guidance clinical management based on current evidence expert opinion regarding definitions, classification, significance lesions. A consensus conference was held over 2 days reviewing topic from perspectives histology, molecular biology,...
PURPOSE To update key recommendations of the American Society Clinical Oncology/College Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS A multidisciplinary international Expert Panel was convened to clinical practice guideline informed by a systematic review medical literature. RECOMMENDATIONS The continues recommend ER invasive cancers validated immunohistochemistry as standard for predicting which patients may benefit from endocrine...
The "hyperplastic polyp" is considered a benign lesion with no malignant potential, whereas "serrated adenoma" precursor of adenocarcinoma. morphologic complexity the serrated adenoma varies from being clearly adenomatous to difficult distinguish hyperplastic polyp, which creates need for more detailed analysis all polyps. We evaluated 24 variables in 289 polyps colon and rectum. Cluster discriminant were performed. A subset was immunostained hMLH1 hMSH2. Major differences found between...
Abstract Purpose.—To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone (PgR) testing in breast cancer utility these receptors as predictive markers. Methods.—The American Society Clinical Oncology College Pathologists convened an international Expert Panel that conducted systematic review evaluation literature partnership with Cancer Care Ontario developed recommendations for optimal IHC ER/PgR performance. Results.—Up 20%...
The morphologic distinction between various serrated polyps of the colorectum may be challenging. sessile adenoma (SSA) and traditional (TSA) difficult using currently available criteria mostly based on cytologic characteristics. We have evaluated 66 including 29 SSA, 18 TSA, 19 hyperplastic for overall shape polyps, architectural features individual crypts, presence eosinophilic cytoplasm, size distribution proliferation maturation zones, as well Ki-67 CK20 expression. extent expression...
Purpose.— To update key recommendations of the American Society Clinical Oncology/College Pathologists estrogen receptor (ER) and progesterone (PgR) testing in breast cancer guideline. Methods.— A multidisciplinary international Expert Panel was convened to clinical practice guideline informed by a systematic review medical literature. Recommendations.— The continues recommend ER invasive cancers validated immunohistochemistry as standard for predicting which patients may benefit from...
Recent characterizations of mucins at the molecular level indicate that least eight mucin genes are expressed by epithelia mucosal surfaces. The purpose this study was to determine whether these cloned mucins, designated MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7, female reproductive tract. Northern blot analysis, in situ hybridization, immunohistochemistry were performed using RNA tissue from surgically removed human tract specimens including endocervix, ectocervix, vagina,...
Standardization of controls, both positive and negative is needed for diagnostic immunohistochemistry (dIHC). The use IHC-negative irrespective type, although well established, not standardized. As such, the relevance applicability controls continues to challenge pathologists laboratory budgets. Despite clear theoretical notion that appropriate serve demonstrate sensitivity specificity dIHC test, it remains unclear which types are applicable and/or useful in day-to-day clinical practice....
Abstract Epidermal growth factor receptor (EGFR) is expressed in approximately 80-85% of colorectal cancer (CRC). While anti-EGFR antibodies benefit some CRC patients, tumors with kirsten rat sarcoma (KRAS) or B-rapidly accelerated fibrosarcoma (BRAF), a proto-oncogene serine/threonine protein kinase mutations are resistant. Here, we developed theranostic approach that uses an antibody-drug conjugate labeled either [225Ac]Ac [89Zr]Zr and evaluated the strategy against KRAS BRAF mutant...
Whereas L26 (anti-CD20) is well established as a B-cell marker of high specificity for use in paraffin-embedded tissues and JCB117 (anti-CD79a) increasingly used, comparable additional pan-B-cell antibody has hitherto not yet been identified. Here we have studied the novel anti-pan-B-cell Pax-5 diagnostic pathology. encodes BSAP (Pax-5), B-cell-specific transcription factor, expression which detectable early pro-B-cell stage subsequently all further stages development until plasma cell where...
Few studies describe the comprehensive immunophenotypic pattern of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in bone marrow and its treatment. This retrospective analysis evaluates diagnostic flow cytometry (FCM) outcome nine patients diagnosed with BPDCN. A four-tube 10-color FCM panel used for diagnosis acute leukemia (AL), showed cells blast gate (CD45dim/low SSC) were positive CD4(bright), CD33(dim), CD56(heterogenous), CD123(bright), CD36, CD38, HLA-DR, CD71. Seven received...