A5006947964- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Medical Image Segmentation Techniques
- Hepatitis C virus research
- Liver Diseases and Immunity
- Ultrasound Imaging and Elastography
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
- Cancer-related Molecular Pathways
- Neurological disorders and treatments
- Advanced Radiotherapy Techniques
- Translation Studies and Practices
- Electromagnetic Fields and Biological Effects
- Image Retrieval and Classification Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Mollusks and Parasites Studies
- AI in cancer detection
- Pediatric Hepatobiliary Diseases and Treatments
- Nuclear Structure and Function
- Cancer, Hypoxia, and Metabolism
McMaster University
2016-2025
Mount Sinai Hospital
2025
Shandong University of Traditional Chinese Medicine
2025
Jinan University
2024
Changchun University of Chinese Medicine
2020-2024
Weatherford College
2024
York Central Hospital
2024
Sinai Hospital
2024
South China Agricultural University
2023-2024
Guangxi Academy of Agricultural Science
2020-2024
Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), they promote stemness hepatocellular carcinoma (HCC) cells under hypoxic conditions. Design Cell counting, migration, self-renewal ability, chemoresistance expression genes were established detect HCC cells. Immunoprecipitation, ubiquitination assay chromatin immunoprecipitation used USP22 HIF1α. patient samples The Cancer Genome Atlas data...
Discriminating between idiosyncratic drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) is critical yet challenging. We aim to develop validate a machine learning (ML)-based model aid in this differentiation. This multicenter cohort study utilised development set from Beijing Friendship Hospital, with retrospective prospective validation sets 10 tertiary hospitals across various regions of China spanning January 2009 May 2023. Different ML algorithms were tested using 24 routine...
Drug treatments for hepatocellular carcinoma (HCC) often fail because of multidrug resistance (MDR). The mechanisms MDR are complex but cancer stem cells (CSCs), which able to self-renew and differentiate, have recently been shown be involved. deubiquitinating enzyme ubiquitin-specific protease 22 (USP22) is a marker CSCs. This study aimed elucidate the role USP22 in HCC underlying mechanisms. Using vitro vivo assays, we found that modified levels were responsible altered drug-resistant...
Background Immunotherapy has facilitated great breakthroughs in the treatment of hepatocellular carcinoma (HCC). However, efficacy and response rate immunotherapy are limited vary among different patients with HCC. TP53 mutation substantially affects expression immune checkpoint molecules multiple cancers. regulatory relationship between programmed death ligand 1 (PD-L1) is poorly studied We aimed to elucidate mechanism PD-L1 HCC statuses assess its role modulating evasion Methods mouse...
Venous invasion (VI) is an independent prognostic indicator in colorectal cancer and may prompt consideration for adjuvant chemotherapy patients with stage II tumors. Recent evidence suggests that VI underreported detection be enhanced by elastin stain. This study aimed (1) to determine the impact of stain on interobserver agreement between gastrointestinal (GI) non-GI pathologists, (2) identify factors associated increased detection. Forty hematoxylin eosin (H&E)-stained slides were...
The decrease of microRNA-452 (miR-452) in gliomas promoted stem-like features and tumorigenesis. However, the role miR-452, especially regulating cancer stem cells (CSCs) hepatocellular carcinoma (HCC) remains ambiguous. We enriched HCC by serial passages hepatospheres with chemotherapeutic agents. Stem-like characteristics including capabilities chemo-resistance, stemness-related gene expression profiling, self-renewal, tumorigenicity metastasis formation were detected. MiR-452 was markedly...
Background and Aims: The disease progression of nonalcoholic fatty liver (NAFLD) from simple steatosis (NAFL) to steatohepatitis (NASH) is driven by multiple factors. Berberine (BBR) an ancient Chinese medicine has various beneficial effects on metabolic diseases, including NAFLD/NASH. However, the underlying mechanisms remain incompletely understood due limitation NASH animal models used. Methods: A high-fat high-fructose diet-induced mouse model NAFLD, best available preclinical model, was...
We have used digitonin-permeabilized cells to examine in vitro nuclear export of glucocorticoid receptors (GRs). In situ biochemical extractions this system revealed a distinct subnuclear compartment, which collects GRs that been released from chromatin and serves as staging area. Unliganded within compartment are not restricted their trafficking they the capacity recycle upon rebinding hormone. Thus, release do require transit through cytoplasm regain functionality. addition,...
Arsenic trioxide (ATO) is a well-accepted chemotherapy agent in managing promyelocytic leukemia. ATO often causes severe health hazards such as hepatotoxicity, dermatosis, neurotoxicity, nephrotoxicity and cardiotoxicity. The production of reactive oxygen species, (ROS) play significant role ATO-induced hepatotoxicity. oral hypoglycemic drug, metformin, considered to be potential novel for chemoprevention the treatment cancer. Moreover, metformin has also been shown have hepatoprotective...
Content-based image retrieval systems for 3-D medical datasets still largely rely on 2-D image-based features extracted from a few representative slices of the stack. Most 2 -D that are currently used in literature not only model tumor incompletely but also highly expensive terms computation time, especially high-resolution datasets. Radiologist-specified semantic labels sometimes along with to improve performance. Since radiological show large interuser variability, often unstructured, and...
Abstract Understanding the genetic basis of pest adaptive evolution and risk adaptation in response to climate change is essential for development sustainable agricultural practices. However, climatic Asian corn borer (ACB), Ostrinia furnacalis, main Asia Oceania, poorly understood. Here, we revealed genomic loci underlying ACB by integrating population environmental factors. We assembled a 471-Mb chromosome-scale reference genome resequenced 423 individuals covering 27 representative...
Glucocorticoid receptors (GRs) are shuttling proteins, yet they preferentially accumulate within either the cytoplasmic or nuclear compartment when overall rates of import export, respectively, limiting. Hormone binding releases from stable heteromeric complexes that restrict their interactions with soluble factors and contribute to retention. Although hormone dissociation leads rapid release GRs chromatin, unliganded delayed in export. We have used a chimeric GR contains heterologous,...
Abstract Unliganded glucocorticoid receptors (GRs) released from chromatin after hormone withdrawal remain associated with the nucleus within a novel subnuclear compartment that serves as nuclear export staging area. We set out to examine whether unliganded cycle between distinct compartments or require cytoplasmic transit regain and chromatin-binding capacity. Hormone-withdrawn rat GrH2 hepatoma cells were permeabilized digitonin deplete factors, then hormone-binding properties of recycled...
Citrus fruits exhibit vivid color and are favored extensively. However, the biochemical molecular mechanism of Reticulata Blanco coloring, especially effect transplantation on is unclear. Herein, RNA-Seq carotenoids profiling were applied to investigate Orah mandarin coloring. Transplantation induces fruit shallowing, Ca2+ ACC level declining IAA increasing. induced variation in skin pulp carotenoids, mainly β-citraurin as one important pigments citrus peel. 2253 up-regulated genes, 1103...
Vanishing bile duct syndrome (VBDS) is a rare condition, representing approximately 0.5% of small diseases, characterized by progressive destruction intrahepatic ducts, leading to ductopenia. This condition encompasses various etiologies, with drug-induced VBDS (D-VBDS) accounting for 7% cases. D-VBDS arises from liver injury due chemical drugs, traditional medicines, and dietary supplements, often resulting in inflammatory responses necrosis epithelium. Recent years have seen rise reported...