A5101818905- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Inflammatory Biomarkers in Disease Prognosis
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Oral and gingival health research
- PI3K/AKT/mTOR signaling in cancer
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Engineering Education and Curriculum Development
- Renal Diseases and Glomerulopathies
- Innovations in Medical Education
Sun Yat-sen University
2013-2025
Key Laboratory of Guangdong Province
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Zhejiang University
2021
First Affiliated Hospital Zhejiang University
2021
Houston Methodist
2007-2014
National Natural Science Foundation of China
2013
Fundación Juan March
2013
GTx (United States)
2011
Immune checkpoint inhibitors (ICIs) may lead to rejection and even graft loss of solid organ transplant recipients, making them not widely used in patients. There is insufficient clinical experience using ICIs as a bridging or downstaging therapy before transplantation. We performed retrospective review patients receiving programmed cell death 1 inhibitor (PD1) liver transplantation for HCC our center analyzed the data these with purpose investigating safety feasibility preoperative PD1...
Background It is of importance to minimize ischemia reperfusion (I/R) injury during liver operations. Reducing the inflammatory reaction an effective way achieve this goal. Notably, adiponectin (APN) was found have anti-inflammatory activity in heart and renal I/R injury. Herein, we investigated role APN Methods Wistar rats were randomized four groups: (1) sham group; (2) control (3) I/R+APN (4) I/R+APN+AMPK inhibitor group. Liver blood samples collected 6h 24h after reperfusion. function...
Organs are fundamental anatomical entities within the human body, each performing distinct physiological functions and serving as sites for various pathological conditions. Current medical research treatment focus primarily on individual a whole or cellular genetic levels. However, due to absence of well-established in vitro organ culture techniques models, at mesoscopic level organs significantly lags behind microscopic macroscopic investigations. This lag restricts efficient translation...
// Fei Ji 1,2,3,* , Shunjun Fu Zhiyong Guo 1,2,3* Hui Pang 4 Dubo Chen 5 Xiaoping Wang 1,2,3 Weiqiang Ju Dongping Xiaoshun He Yunpeng Hua 6 and Baogang Peng 1 Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China 2 Guangdong Provincial Key Laboratory of Donation Immunology, 3 International Cooperation Base Science Technology (Organ Transplantation), Department Medical Records, Medicine, Liver Surgery, * These authors have contributed equally...
Abstract Background The global incidence of liver diseases is rising, yet there remains a dearth precise research models to mimic these diseases. use normothermic machine perfusion (NMP) study diseased livers recovered from transplantation (LT) recipients presents promising avenue. Accordingly, we have developed system tailored specifically for the human whole and present our experience NMP livers. Methods Six LT with different diagnoses were collected. connected that circulated perfusate,...
Transplant rejection remains a major barrier to graft survival and involves diversity of cell types. However, the heterogeneity each type in allograft poorly defined. In present study, we used single-cell RNA sequencing technology analyze graft-infiltrating cells describe types states associated with acute mouse heart transplant model. Unsupervised clustering analysis revealed 21 distinct populations. Macrophages formed five clusters: two resident macrophage groups, infiltrating groups one...
CHINA ARRIVING IN THE INTERNATIONAL TRANSPLANT COMMUNITY Organ transplantation in China has a long history of success and challenges. Since the 1960s, animal experiments have been performed organ transplantation, providing foundation for successful clinical procedures. In 1972, our center first living donor kidney China. then, liver transplant programs evolved. By beginning 21st century, had advanced, transplants successfully at First Affiliated Hospital Sun Yat-sen University.1 shortage...
Abstract Background Cerebrovascular complications are severe events following orthotopic liver transplantation (OLT). This study aimed to observe the clinical and neuroimaging features possible risk factors of in-hospital cerebrovascular in patients who underwent OLT. Patients methods We retrospectively reviewed 337 consecutive 358 OLTs. were determined by manifestations, analyzed with intracranial hemorrhage. Results Ten (3.0%) developed (8 cases experienced hemorrhage 2 had cerebral...
To compare the efficacy and safety between rabbit anti-thymocyte globulin (Thymoglobulin) anti-T lymphocyte (ATG-Fresenius, ATG-F) in donation after cardiac death (DCD) kidney transplantation.We retrospectively analyzed 255 cases of DCD transplantation performed at our hospital from February 2007 to October 2013. The patients were divided into two groups based on their induction therapies with Thymoglobulin (n = 188) or ATG-F 67). Clinical data collected compared groups.Delayed graft...
This study aimed to evaluate the predictive power of five available delayed graft function (DGF)-prediction models for kidney transplants in Chinese population.Among models, Irish 2010 model scored best performance population. had an area under receiver operating characteristic (ROC) curve 0.737. Hosmer-Lemeshow goodness-of-fit test showed that a strong correlation between calculated DGF risk and observed incidence (p = 0.887). When was used clinic, optimal upper cut-off set 0.5 with...
To evaluate the efficacy and safety of conversion from calcineurin inhibitors to sirolimus among liver transplant recipients with inhibitor-induced complications.After receiving transplants, 25 patients complications (22 renal dysfunction 3 new-onset diabetes mellitus) were converted tacrolimus. The serum creatinine, trough level, function, acute rejection episodes, drug-related adverse effects monitored.The followed for 12 50 months (median, months). function 22 improved after conversion....
The establishment of a national organ donation and transplantation system has gone through long difficult process in China. A nationwide that followed the guiding principles World Health Organization conformed to our conditions was initially established under leadership Chinese National Family Planning Commission (NHFPC) China Red Cross Federation after 10-years unremitting efforts. This symbolized new era history during which citizens voluntary donations is sole legitimate source for...
In 2011, a pilot program of organ donation after cardiac death was begun at the First Affiliated Hospital Sun Yat-sen University, Guangzhou, China, where we hosted one largest transplant programs in country. We report our initial single-center experiences kidney from deaths.From January 2011 to July 2013 center, 101 transplants donors were performed. The results compared with those 50 brain performed during same time.Delayed graft function occurred more frequently than kidneys (16.8% vs...