A5076136205- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Carbon dioxide utilization in catalysis
- Drug-Induced Hepatotoxicity and Protection
- Bacteriophages and microbial interactions
- CO2 Reduction Techniques and Catalysts
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Pediatric Hepatobiliary Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Surfactants and Colloidal Systems
- Liver Disease and Transplantation
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- IL-33, ST2, and ILC Pathways
- Cystic Fibrosis Research Advances
- Virus-based gene therapy research
- Hepatitis C virus research
- Surface Modification and Superhydrophobicity
- Machine Learning in Bioinformatics
- Fluid Dynamics and Thin Films
- Hepatitis B Virus Studies
- Mesoporous Materials and Catalysis
- Polymer Foaming and Composites
Yale University
2008-2025
Chinese PLA General Hospital
2020-2025
Hangzhou DAC Biotech (China)
2025
State Key Laboratory of Chemical Engineering
2024
East China Normal University
2012-2024
Creative Commons
2023
Peking University
2021-2023
Peking University International Hospital
2023
Shanxi Medical University
2020-2023
Kunming Children's Hospital
2016-2023
Discriminating between idiosyncratic drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) is critical yet challenging. We aim to develop validate a machine learning (ML)-based model aid in this differentiation. This multicenter cohort study utilised development set from Beijing Friendship Hospital, with retrospective prospective validation sets 10 tertiary hospitals across various regions of China spanning January 2009 May 2023. Different ML algorithms were tested using 24 routine...
Abstract Background and Aim graphic Ursodeoxycholic acid ( UDCA ) treatment is an effective medical therapy for patients with primary biliary cirrhosis PBC ); however, 40% of show incomplete response to the therapy. This study aimed investigate safety efficacy umbilical cord‐derived mesenchymal stem cell UC‐MSC transfusion in . Methods We conducted a single‐arm trial that included seven suboptimal treatment. UC ‐ MSCs were first cultured, then 0.5 × 10 6 cells/kg body weights infused through...
There is increasing interest in the role of T follicular helper (Tfh) cells autoimmunity from perspective both their breach tolerance and effects on natural history disease progression. Indeed, critical Tfh further highlighted based location germinal center (GC), a pathogenic hot spot for development autoreactivity. To address primary biliary cirrhosis (PBC), we comprehensively evaluated immunobiology CXCR5 + CD4 69 patients with PBC, including nested subgroup 16 autoimmune hepatitis (AIH)...
We report the first highly selective kinetic resolution of racemic α-chiral azides via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). Newly developed pyridine-bisoxazoline (PYBOX) ligands, bearing a C4 sulfonyl group, enable effective derived from privileged scaffolds such as indanone, cyclopentenone, and oxindole, their asymmetric CuAAC to afford α-tertiary 1,2,3-triazoles with high excellent ee values. DFT calculations control experiments reveal that group decreases Lewis basicity ligand...
Abstract Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked centennial of Felix d’Hérelle’s first publication on clinical applications phages. At Center for Phage Biology & Therapy at Yale University, a preparatory modular approach has been established offer safe potent phages single-patient investigational new drug while recognizing time constraints imposed by infection(s). This study provides...
Autoimmune hepatitis (AIH) is often confused with other liver diseases because of their shared nonspecific symptoms and serological histological overlap. This study compared the plasma metabolomic profiles patients AIH, primary biliary cirrhosis (PBC), PBC/AIH overlap syndrome (OS), drug-induced injury (DILI) those healthy subjects to identify potential biomarkers AIH. Metabolomic profiling biomarker screening were performed using proton nuclear magnetic resonance spectroscopy (1H NMR)...
Summary Background Treatment of chronic drug‐induced liver injury (DILI) or herb‐induced injury(HILI) is an important and unresolved challenge. There no consensus regarding the indications for corticosteroids DILI/HILI. Aims To investigate efficacy safety corticosteroid plus glycyrrhizin patients with Methods This was a randomised open‐label trial. Eligible causality assessment using updated RUCAM were randomly assigned (1:1) either to steroid treatment group (48‐week stepwise dose reduction...
An immunotherapy treatment for cancer that targets both the tumor vasculature and cells has shown promising results in a severe combined immunodeficient mouse xenograft model of human melanoma. The involves systemic delivery an immunoconjugate molecule composed tumor-targeting domain conjugated to Fc effector IgG1. induces cytolytic immune response against targeted by natural killer complement. Two types targeting domains were used. One is single-chain Fv binds chondroitin sulfate...
Abstract Bacteriophage therapy, which uses lytic viruses as antimicrobials, has received renewed interest to address the emerging antimicrobial resistance (AMR) crisis. Cystic fibrosis (CF), a disease complicated by recurrent P. aeruginosa pulmonary infections that cause lung function decline, is an example where AMR already clinical problem. While bacteria evolve bacteriophage resistance, we developed strategy select bacteriophages target bacterial cell surface receptors contribute...