A5017786401- Pancreatitis Pathology and Treatment
- Natural product bioactivities and synthesis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Phytochemistry and Biological Activities
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diabetes and associated disorders
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- SARS-CoV-2 and COVID-19 Research
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and disorders
- Computational Drug Discovery Methods
- Bladder and Urothelial Cancer Treatments
- Phytochemistry and Bioactive Compounds
- Appendicitis Diagnosis and Management
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Bacteriophages and microbial interactions
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Zhengzhou University
2017-2025
Sichuan University
2015-2025
West China Hospital of Sichuan University
2018-2025
University of North Carolina at Chapel Hill
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
West China Medical Center of Sichuan University
2012-2024
Xian Yang Central Hospital
2024
Second Hospital of Yichang
2018-2024
China Three Gorges University
2020-2024
West China Second University Hospital of Sichuan University
2023
Rationale: Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than reduced fraction. Complexity its pathophysiology and the lack animal models hamper development effective therapy for HFpEF. Objective: This study was designed to investigate metabolic mechanisms HFpEF test therapeutic interventions using a novel model. Methods Results: By combining age, long-term high-fat diet, desoxycorticosterone pivalate challenge in mouse model, we were able recapture...
Depth sensors could be a portable, affordable, marker-less alternative to three-dimension motion capture systems for gait analysis, but the effects of camera viewing angles on their joint angle tracking performance have not been fully investigated.This study evaluated accuracies three depth [Azure Kinect (AK); v2 (K2); Orbbec Astra (OA)] kinematic patterns during treadmill walking at five (0°/22.5°/45°/67.5°/90°).Ten healthy subjects performed fifteen trials (3 speeds × 5 angles) using...
The glycoprotein spike (S) on the surface of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a determinant for viral invasion and host immune response. Herein, we characterized site-specific N-glycosylation S protein at level intact glycopeptides. All 22 potential N-glycosites were identified in S-protein protomer found to be preserved among 753 SARS-CoV-2 genome sequences. glycosites exhibited glycoform heterogeneity as expected human cell-expressed subunit. We masses that...
The ongoing outbreak of COVID-19 has been a serious threat to human health worldwide. virus SARS-CoV-2 initiates its infection the body via interaction spike (S) protein with Angiotensin-Converting Enzyme 2 (ACE2) host cells. Therefore, understanding fundamental mechanisms how S receptor binding domain (RBD) binds ACE2 is highly demanded for developing treatments COVID-19. Here we implemented multi-scale computational approaches study and proteins both SARS-CoV SARS-CoV-2. Electrostatic...
Innate immunity and metabolites link to the pathogenesis severity of acute pancreatitis (AP). However, liver metabolism its role in immune response AP progression remain elusive. We investigated function AP.Circulating ketone body β-hydroxybutyrate (βOHB) levels were determined clinical cohorts caerulein-induced (CER-AP) mouse models receiving seven (Cer*7) or twelve (Cer*12) injection regimens at hourly intervals. Liver transcriptomics metabolomics compared between CER-AP (Cer*12)....
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies with relatively high morbidity and mortality. Emerging evidence suggests circular RNAs (circRNAs) play critical roles in tumor malignancy. However, biological function clinical significance many circRNAs ESCC remain elusive. Methods The expression level implication circRUNX1 tissues were evaluated using qRT-PCR. In vitro vivo functional studies conducted to investigate underlying...
Extracellular vesicle (EV)-based immunotherapeutics have emerged as promising strategy for treating diseases, and thus, a better understanding of the factors that regulate EV secretion function can provide insights into developing advanced therapies. Here, we report nutrient availability, even changes in individual components, may affect biogenesis composition immune cells [e.g., macrophages (Mφs)]. As proof concept, EVs from M1-Mφ under glutamine-depleted conditions (EV
Thirteen new thiodiketopiperazines, epicoccin I (1), ent-epicoccin G (2), and epicoccins J−T (3−13), together with six known diketopiperazines (14−19), have been isolated from the endophytic fungus Epicoccum nigrum. The structures of 1, 2, 10 were confirmed by X-ray crystallography, absolute configurations 4, 6, 8 assigned using Moshers' method. Compounds 12, 17 showed potent activities in vitro against release β-glucuronidase rat polymorphonuclear leukocytes induced platelet-activating...
Chaiqin chengqi decoction (CQCQD) is a Chinese herbal formula derived from dachengqi decoction. CQCQD has been used for the management of acute pancreatitis (AP) in West China Hospital more than 30 years. Although well-established clinical efficacy, little known about its bioactive ingredients, how they interact with different therapeutic targets and pathways to produce anti-inflammatory effects. Toll-like receptor 4 (TLR4) nucleotide-binding oligomerization domain-like family pyrin domain...
Tumor-derived exosomes are highly correlated with tumor progression and angiogenesis. This study was designed to probe the role of tumor-derived exosomal miR-1247-3p in mediating angiogenesis bladder cancer. Exosomes isolation from culture medium normal or cancer cell lines performed using a differential centrifugation method. expression cells detected by quantitative real-time PCR (qRT-PCR). The effect on human umbilical vein endothelial (HUVECs) assessed counting kit-8 (CCK-8), transwell...
RNA modifications of transfer RNAs (tRNAs) are critical for tRNA function. Growing evidence has revealed that related to various disease processes, including malignant tumors. However, the biological functions methyltransferase-like 1 (METTL1)-regulated m7G in breast cancer (BC) remain largely obscure. The role METTL1 BC progression were examined by cellular loss- and gain-of-function tests xenograft models both vitro vivo. To investigate change modification mRNA translation efficiency BC,...
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options. Although inhibiting xanthine oxidase (XO) in the of AP has been studied several experimental models and clinical trials, whether XO target what its main mechanism action remains unclear. Here, we aimed to re-evaluate aggravating other than merely generating reactive oxygen species that trigger AP. We first revealed expression enzyme activity were significantly elevated serum pancreas necrotizing...
Drug-resistant bacterial infections and lack of available antibacterial agents in clinical practice are becoming serious risks to public health. We synthesized a new class haloemodins by modifying traditional Chinese medicine component, emodin. The novel haloemodin exerts strong inhibitory activity on topoisomerase I DNA gyrase, not the topoisomerases human origin. In principle, it shows remarkable activities against laboratory clinically isolated Gram-positive bacteria, including...
Summary The glycoprotein spike (S) on the surface of SARS-CoV-2 is a determinant for viral invasion and host immune response. Herein, we characterized site-specific N-glycosylation S protein at level intact glycopeptides. All 22 potential N-glycosites were identified in S-protein protomer found to be preserved among 753 genome sequences. glycosites exhibited glycoform heterogeneity as expected human cell-expressed subunits. We masses that correspond 157 N-glycans, primarily complex type. In...
Stress hyperglycemia is common in critical illness but it has not been clearly studied patients with acute pancreatitis (AP). This study aimed to investigate the specific blood glucose (BG) level that defines stress and determine impact of on clinical outcomes AP patients. admitted ≤ 48 h after abdominal pain onset were retrospectively analyzed. Patients stratified by pre-existing diabetes was defined using BG levels for non-diabetes compared. There 967 non-diabetic 114 diabetic (10.5%) met...
Aerobic glycolysis has been considered as a hallmark of colorectal cancer (CRC). However, the potential functional regulators in CRC remains to be elucidated. In current study, we found that Regenerating islet-derived protein 1-alpha (REG1α) was significantly increased both tissues and serum, positively associated with patients' lymph node metastasis, advanced tumor stage, unfavorable prognosis. Ectopic expression REG1α contributed various tumorigenic properties, including cell...
Breast cancer (BC) is one of the most frequent cancer-related deaths in women worldwide. Studies have shown potential impact circRNAs multiple human tumorigeneses. Research on vital signaling pathways and therapeutic targets indispensable. Here, we aimed to investigate clinical implications underlying mechanisms circ_0042881 BC. RT-qPCR validated was notably elevated BC tissues plasma, closely associated with clinicopathological features. Functionally, significantly accelerated...
Introduction The Paris System ( TPS ) has recently been used in classification of urinary tract cytological specimens. Upper UUT specimens are cytologically challenging. utility was investigated evaluating and its correlation with subsequent histological follow‐up. Method From 2014 to 2017, 324 cytology cases from 179 patients were retrieved. Concurrent or biopsy resection within a 2‐month period available 125 74 patients. Result None the low‐grade urothelial neoplasm found have high‐grade...