A5101941097- Cancer, Hypoxia, and Metabolism
- Intensive Care Unit Cognitive Disorders
- Bone fractures and treatments
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Orthopedic Surgery and Rehabilitation
- Facial Trauma and Fracture Management
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- High Altitude and Hypoxia
- Proteoglycans and glycosaminoglycans research
- BRCA gene mutations in cancer
- Neurological Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Cardiovascular Disease and Adiposity
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Spinal Fractures and Fixation Techniques
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Drug Transport and Resistance Mechanisms
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
Tsinghua University
2013-2023
West China Medical Center of Sichuan University
2022-2023
Sichuan University
2013-2022
West China Hospital of Sichuan University
2013-2022
National Clinical Research
2020
Tumor Hospital of Guangxi Medical University
2019
Rationale: Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than reduced fraction. Complexity its pathophysiology and the lack animal models hamper development effective therapy for HFpEF. Objective: This study was designed to investigate metabolic mechanisms HFpEF test therapeutic interventions using a novel model. Methods Results: By combining age, long-term high-fat diet, desoxycorticosterone pivalate challenge in mouse model, we were able recapture...
Abstract Objective Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties exhibited therapeutic effects animal models of several degenerative disorders. However, effect trehalose on AD pathology remains largely unknown. Methods In this study, we evaluated APP/PS1 transgenic mice through...
Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain be elucidated. This study was designed investigate impact of acclimation (HA) on cardiac I/R and antioxidative mechanism(s). Male adult mice were acclimated a chamber (10% oxygen [O2]) for 8 h/day 14 days, then subjected by ligation...
Background & Aims: SLC25A47 was initially identified as a mitochondrial HCC-downregulated carrier protein, but its physiological functions and transport substrates are unknown. We aimed to investigate the role of in hepatic metabolism. Approach Results: In treatment hepatocytes with metformin, we found that metformin can transcriptionally activate expression Slc25a47 , which is required for AMP-activated protein kinase α (AMPKα) phosphorylation. -deficient mice had increased lipid...
Abstract Background Previous Mendelian randomization (MR) studies on obesity and risk of breast cancer adopted a small number instrumental variables focused mainly the crude total effect. We aim to investigate independent causal effect susceptibility, considering distribution fat, covering both early late life. Methods Using an enlarged set female-specific genetic variants associated with adult general [body mass index (BMI)] abdominal [waist-to-hip ratio (WHR) without adjustment for BMI,...
Purpose: Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning been demonstrated to provide neuroprotection and brain recovery from both acute chronic neurodegeneration in several cellular animal models. However, the mechanism not well elucidated. Therefore, present study was designed investigate expression of glucose transporters (GLUT1 GLUT3) mitochondrial division fusion (Drp1 Mfn2) proteins rats exposed hypoxic attenuate...
Abstract Diabetic neuropathy (DNP) is the most common complication of diabetes mellitus affecting approximately 50% patients. Studying effect potential drugs with antioxidant properties and minimal toxicities on neural cells may lead to development new safe pharmacotherapy. Dexmedetomidine (DEX), a highly selective α2-adrenoceptor agonist, clinically used sedative also known have protection effect. In present study, we aimed investigate protective role DEX in high glucose (HG)-induced injury...
Abstract Aims Alcohol intake is a risk factor for cardiovascular diseases. This study was designed to investigate whether chronic alcohol affects myocardial infarction (MI)-induced cardiac remodeling and heart failure. Methods Eight-week-old male C57BL/6 mice were randomly divided into four groups: Sham group (Sham), MI plus drinking water (MI + Vehicle), daily 6 weeks with or without gavage of additional every 3 days G). The induced by permanent left anterior descending (LAD) coronary...
Objective To evaluate the diagnostic efficacy of Kwak and ACR(2017) thyroid imaging reporting data systems(TI-RADS) for nodules. Methods Cases nodule who underwent surgery from January 2015 to March 2018 in 15 hospitals Sichuan province were collected ultrasonographic features nodules retrospectively analyzed by trained senior ultrasound physicians using ACR TI-RADS classification methods. Totally, 12 712 observed, 7 023 cases with complete surgical pathological eventually enrolled...
Objective To observe the expression and distribution of NLRP3 in rats brain to explore significant correlations between cerebral ischemia/reperfusion(IR) injuries. Methods Forty Male SD were randomly divided into Sham group, ischemia/reperfusion 12h, 24h, 48h group. The ischemia model was induced by occlusion middle artery (MCAO) with a microfilament rats. explored immunofluorescence staining. After reperfusion injury, we examined levels protein mRNA Western blot real-time PCR,...
Objective To investigate the clinical significance of external fixators combined with vacuum sealing drainage (VSD) in early treatment open distal tibial fractures after Lushan earthquake.Methods The study involved 22 cases severe associated soft tissue defects treated VSD stage earthquake.There were 9 males and 13 females,at age 25-85 years (mean 42.6 years).Causes for injury hitting by heavy objects 19 fall from height three cases.Gustilo classification fracture type Ⅱ four cases,type ⅢA...
Objective To assess the outcomes of surgical treatment supination external rotation trimalleolar fractures,comparing techniques lateral plating and antiglide as described previously.Methods This is a retrospective review.A total 31 patients meeting our inclusion criteria,with fractures surgically treated between 2009 2011,were studied.17 were with plating,whereas remaining 14 underwent traditional plating.They followed up by period ranging from to 38 months(average,26 months).The functional...
To investigate the effect of short-term intermittent hypoxia (IH) on structure and function mouse myocardium.Thirty male C57BL6/J mice were randomly assigned to two groups, a control (Con) group an IH exposed hypoxic treatment at atmospheric pressure. The received 10% oxygen pretreatment for 8 hours per day 14 consecutive days, while Con was normoxia environment all other identical those given group, body mass monitored daily during treatment. exercise tolerance cardiac isolated heart...
To investigate the effect of long-term ethanol consumption on learning-memory functions in mice and mechanisms involved.Thirty male C57BL6/J were randomly assigned to 3 groups, with 10 each group. The three groups included a control group which given water ad libitum for 30 days, group, or EtOH 6% (volume fraction) alcoholism EtOH+G 5% days plus intermittent intragastric gavage 20% at 3.5 g per kilogram body mass once every days. After evaluated. At conclusion experiment, brain tissue was...