A5052857671- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Multiple Sclerosis Research Studies
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Tracheal and airway disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Systemic Lupus Erythematosus Research
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neuropharmacology Research
- China's Socioeconomic Reforms and Governance
- Corneal Surgery and Treatments
- Lung Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Ultrasound in Clinical Applications
- Corneal surgery and disorders
- PARP inhibition in cancer therapy
Sichuan University
2014-2025
West China Hospital of Sichuan University
2014-2025
Fudan University
2014-2025
Huashan Hospital
2010-2025
Zhejiang Normal University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Yangzhou University
2024
First Affiliated Hospital of Jinan University
2024
National Heart Institute
2024
University of Virginia
2014-2022
Rationale: Over 50% of patients with heart failure have preserved ejection fraction (HFpEF), rather than reduced fraction. Complexity its pathophysiology and the lack animal models hamper development effective therapy for HFpEF. Objective: This study was designed to investigate metabolic mechanisms HFpEF test therapeutic interventions using a novel model. Methods Results: By combining age, long-term high-fat diet, desoxycorticosterone pivalate challenge in mouse model, we were able recapture...
The aim is to diagnose COVID-19 earlier and improve its treatment by applying medical technology, the "COVID-19 Intelligent Diagnosis Treatment Assistant Program (nCapp)" based on Internet of Things. Terminal eight functions can be implemented in real-time online communication with "cloud" through page selection key. According existing data, questionnaires, check results, diagnosis automatically generated as confirmed, suspected, or suspicious 2019 novel coronavirus (2019-nCoV) infection. It...
Abstract Quercetin, a dietary flavonol, has been used as potential ingredient in food supplements to promote health. Its health effects are closely related its bioavailability and further depend on absorption, metabolism excretion vivo . Here, we systematically summarized the absorption of quercetin human intestine, liver, kidney, highlighting transport metabolic pathways, intermediate metabolites, circulation channels involving quercetin. The bioactivities theintestine, kidney were also...
Abstract Postoperative cognitive dysfunction (POCD) is common and associated with poor outcome. Neural circuit involvement in POCD unknown. Lateral habenula (LHb) that regulates coping depression‐like behaviors after aversive stimuli activated by surgery the previous study. Here, LHb ventral tegmental area (VTA) are presented. VTA known to receive projections from project prefrontal cortex hippocampus. Direct chemogenetic inhibition of or damaging attenuates surgery‐induced learning memory...
Whether microglial activation plays an important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. [18F]-DPA714 PET targeting translocator protein (TSPO) is a novel method to detect neuroinflammation via visualizing activated microglia. In this study, we aimed investigate application anti-LGI1 encephalitis. Patients with and non-inflammatory controls (NIC) underwent scans were enrolled. Standardized...
<h3>Background and Objectives</h3> To characterize the clinical neuroimaging phenotypes of patients with autoantibodies to γ-aminobutyric acid type A receptor (GABA<sub>A</sub>R). <h3>Methods</h3> Ten against GABA<sub>A</sub>R from Huashan Hospital Autoimmune Encephalitis cohort were identified. We used MRI assessments examinations summarize major profile visualize quantify lesion distribution features. The relationship between features, phenotypes, topology expression further investigated....
BACKGROUND: The effect of anesthesia regimens on postoperative delirium after on-pump cardiac valve surgery is yet undetermined. This study aimed to evaluate the volatile compared with propofol-based total intravenous (TIVA) occurrence surgery. METHODS: randomized clinical trial was conducted at a university academic hospital in China, from February 2019 January 2021. Patients scheduled for or combined coronary artery bypass grafting (CABG) surgeries were randomly assigned receive...
The effect of intraoperative anesthetic regimen on pulmonary outcome after minimally invasive esophagectomy for esophageal cancer is yet undetermined. aim this study was to determine the volatile anesthesia (sevoflurane or desflurane) compared with propofol-based intravenous complications esophagectomy.
Objective The sedative dexmedetomidine plays a role in multi-organ protection by inhibiting toll-like receptor (TLR) 4 expression ischemia/reperfusion injury. present study investigated whether the neuroprotective effects of could be blocked TLR4 agonist lipopolysaccharide. Methods We established cerebral model neonatal Sprague-Dawley rats through bilateral carotid artery occlusion for 20 minutes followed 2-hour reperfusion. Rats were assigned to four groups: Sham operation,...
Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the mechanism is unclear. The effects of isoflurane on sodium channel currents were analyzed in acute mouse brain slices, including leak (NALCN) and voltage-gated channels (Nav) currents. Isoflurane sub-anesthetic concentrations increased spontaneous firing rate CA3 pyramidal neurons, whereas anesthetic decreased...
Oleifolioside A, a new triterpenoid compound isolated from Dendropanax morbifera Leveille (D. morbifera), was shown in this study to have potent inhibitory effects on lipopolysaccharide (LPS-)stimulated nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production RAW 264.7 macrophages. Consistent with these findings, oleifolioside A further suppress the expression of LPS-stimulated inducible synthase (iNOS) cyclooxigenase-2 (COX-2) dose-dependent manner at both protein mRNA levels...
β-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in variety of human cancer cells vitro and vivo; however, its mechanism action needs to be further elaborated. In this study, we investigated the effects on induction apoptosis gastric carcinoma AGS cells. significantly inhibited cellular proliferation, some typical characteristics such as chromatin condensation an increase population sub-G1 hypodiploid were observed β-lapachone-treated Treatment with...
Abstract Background To determine whether maintaining ventilation during cardiopulmonary bypass (CPB) with a different fraction of inspired oxygen (FiO 2 ) had an impact on the occurrence postoperative pulmonary complications (PPCs). Methods A total 413 adult patients undergoing elective cardiac surgery CPB were randomly assigned into three groups: 138 in NoV group (received no mechanical CPB), LOV tidal volume (V T 3–4 ml/kg ideal body weight respiratory rate 10–12 bpm, and positive...
BACKGROUND: The effect of general anesthetics (propofol and volatile anesthetics) on pulmonary outcome after lung resection surgery with one-lung ventilation (OLV) is yet undetermined. We evaluated the intravenous anesthesia (propofol) (sevoflurane or desflurane) regimens postoperative complications (PPCs) in patients undergoing surgery. METHODS: This prospective, randomized controlled trial enrolled 555 adult scheduled for OLV. Participants were to 1 3 anesthetic (propofol, sevoflurane,...
We report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in patient with concomitant antibodies N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The exhibited constellation symptoms, including vision loss, seizures, mental behavioral disorders, cognitive impairment, speech abnormalities. At the two-year follow-up, patient's symptoms had abated entirely. Overlap syndrome triple is rare...