A5101772464- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Autoimmune Neurological Disorders and Treatments
- Amyotrophic Lateral Sclerosis Research
- Adenosine and Purinergic Signaling
- Peripheral Neuropathies and Disorders
- Chronic Kidney Disease and Diabetes
- Neurogenetic and Muscular Disorders Research
- NF-κB Signaling Pathways
- Drug Solubulity and Delivery Systems
- Platelet Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Salivary Gland Disorders and Functions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renin-Angiotensin System Studies
- S100 Proteins and Annexins
- Artificial Intelligence in Healthcare and Education
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Protein Tyrosine Phosphatases
- Cervical Cancer and HPV Research
- Monoclonal and Polyclonal Antibodies Research
- Biochemical effects in animals
Huashan Hospital
2024-2025
Fudan University
2017-2025
First Affiliated Hospital of Gannan Medical University
2022-2024
Peking University
2023
Second Affiliated Hospital of Fujian Medical University
2023
Fujian Medical University
2023
Peking University Third Hospital
2023
Ruijin Hospital
2023
Qingdao Eighth People's Hospital
2019
Yan'an University
2018
To examine the effect of dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on major components renal glucose reabsorption (decreased maximum reabsorptive capacity [TmG], increased splay, and reduced threshold), using pancreatic/stepped hyperglycemic clamp (SHC) technique.Subjects with type diabetes (n=12) matched healthy subjects underwent pancreatic/SHC (plasma range 5.5-30.5 mmol/L) at baseline after 7 days dapagliflozin treatment. A pharmacodynamic model was developed to...
This study assessed the effect of differences in renal function on pharmacokinetics and pharmacodynamics dapagliflozin, a sodium glucose co-transporter-2 (SGLT2) inhibitor for treatment type 2 diabetes mellitus (T2DM).A single 50 mg dose dapagliflozin was used to assess five groups: healthy non-diabetic subjects; patients with T2DM normal kidney mild, moderate or severe impairment based estimated creatinine clearance. Subsequently, 20 once daily multiple doses were evaluated T2DM. Formation...
ABSTRACT Background The diagnostic and prognostic values of serum neurofilament light chain (sNfL), in comparison to cerebrospinal fluid (CSF) (cNfL), other clinical parameters amyotrophic lateral sclerosis (ALS) at the time diagnosis remain elusive. Methods We examine paired CSF samples from 80 ALS patients 21 control subjects, all obtained diagnosis. Additional were collected 51 patients. NfL concentrations quantified using single molecule array (Simoa) technique. Results Our findings...
Whether microglial activation plays an important role in the pathogenesis of autoimmune encephalitis (AE), such as anti-leucine-rich, glioma-inactivated-1 (LGI1) encephalitis, remains unknown. [18F]-DPA714 PET targeting translocator protein (TSPO) is a novel method to detect neuroinflammation via visualizing activated microglia. In this study, we aimed investigate application anti-LGI1 encephalitis. Patients with and non-inflammatory controls (NIC) underwent scans were enrolled. Standardized...
We report pharmacokinetics, pharmacodynamics, and safety of a novel anti-CD28 domain antibody antagonist (lulizumab pegol) in healthy subjects following single- or multiple-dose administration. A minimal anticipated biological effect level approach was used to select 0.01 mg starting dose for single-ascending-dose (SAD), double-blind, first-in-human study. Part 1 included 9 intravenous (IV; 0.01-100 mg) 3 subcutaneous (SC; 9-50 doses placebo. In part 2, keyhole limpet hemocyanin (KLH)...
We aimed to characterize the phenotype of neuromyelitis optica spectrum disorder (NMOSD) in presence and absence Sjogren's disease (SjD) develop a predictive nomogram evaluate risk coexisting SjD within single tertiary-center cohort NMOSD patients. Paraclinical clinical features patients with were compared between those without SjD. Zstats v1.0 was utilized randomly allocate participants into derivation group (108 patients) validation (47 at ratio 7:3. Logistic regression analysis used...
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The contribution of peripheral abnormalities to disease's pathogenesis is not well understood.
BACKGROUND: Nearly half of adult acute myeloid leukemia (AML) patients were classified into cytogenetic normal (CN-AML). The expression level Trophinin associated protein (TROAP) was proven to be with the prognosis several cancers, but it is still unclear in CN-AML. METHODS: We integrated CN-AML patient samples from 4 datasets analyze relationship between TROAP and survival In addition, we investigated 92 AML Cancer Genome Atlas (TCGA) database received chemotherapy. drug sensitivity cell...
SM-like (LSM) genes a family of RNA-binding proteins, are involved in mRNA regulation and can function as oncogenes by altering stability. However, their roles B-cell progression tumorigenesis remain poorly understood.
Objective To investigate the association between angiotensin-converting enzyme (ACE) gene rs4353, rs4461142, rs8066114 polymorphism and diabetic microangiopathy. Methods A total of 675 patients with type 2 diabetes mellitus (T2DM) hospitalized in Yan′an People′s Hospital from January 2016 to 2017 were recruited participate study. According their status microangiopathy, they divided into retinopathy (DR)+ /diabetic nephropathy(DN) + group (n=130), DR+ /DN- (n=118), DR-/DN+ (n=236)...
Abstract At present, many patients still need outpatient triage help. ChatGPT is increasingly used in medicine. Here, we assess the utility of triage. We found that ChatGPT's answer very professional, comprehensive, and humanistic, can be applied to provide better medical care for patients.
Objective To explore the effect of early preventive nursing on improving quality life and satisfaction patients with chronic bronchitis emphysema. Methods 86 emphysema admitted to our hospital from February, 2016 August, 2018 were selected as research objects, divided into a control group an experimental group, 43 cases for each group. The took routine nursing, such regular medication patrol. including health education, breathing training, dietary guidance, psychological counseling....