A5057719232- X-ray Diffraction in Crystallography
- Soil Carbon and Nitrogen Dynamics
- Crystallization and Solubility Studies
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Mycorrhizal Fungi and Plant Interactions
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Metal-Organic Frameworks: Synthesis and Applications
- Mechanical Behavior of Composites
- Cellular and Composite Structures
- Bioactive Natural Diterpenoids Research
- Photosynthetic Processes and Mechanisms
- Advancements in Battery Materials
- Covalent Organic Framework Applications
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Luminescence and Fluorescent Materials
- Advanced Battery Materials and Technologies
- Traditional and Medicinal Uses of Annonaceae
- Supramolecular Self-Assembly in Materials
- Advanced Battery Technologies Research
- Advanced Antenna and Metasurface Technologies
- Bioenergy crop production and management
Southern University of Science and Technology
2018-2025
Nanjing University of Chinese Medicine
2025
Taiyuan University of Technology
2015-2024
Zhejiang A & F University
2021-2023
CanSino (China)
2023
Huazhong University of Science and Technology
2021-2023
Anhui Agricultural University
2022-2023
Second Artillery General Hospital of Chinese People's Liberation Army
2023
Southeast University
2023
Zunyi Medical University
2021-2022
CavityPlus is a web server that offers protein cavity detection and various functional analyses. Using three-dimensional structural information as the input, applies CAVITY to detect potential binding sites on surface of given structure rank them based ligandability druggability scores. These can be further analysed using three submodules, CavPharmer, CorrSite, CovCys. CavPharmer uses receptor-based pharmacophore modelling program, Pocket, automatically extract features within cavities....
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) resulted from the outbreak SARS-CoV-2 in December 2019. Currently, multiple efforts are being made to rapidly develop vaccines and treatments fight COVID-19. Current vaccine candidates use inactivated viruses; therefore, it is important understand architecture SARS-CoV-2. We have genetically structurally characterized β-propiolactone-inactivated viruses a propagated purified clinical strain observed that virus particles...
Cryo-electron microscopy study finds that EC-based electrolyte can exfoliate the graphite surface and destabilize SEI. Useful additives including FEC, DTD, TPP, VC form a stable SEI to protect anode.
Nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen effectors to trigger plant immunity. The direct recognition mechanism of by coiled-coil NLRs (CNLs) remains unclear. We demonstrate that the Triticum monococcum CNL Sr35 directly recognizes effector AvrSr35 from Puccinia graminis f. sp . tritici and report a cryo–electron microscopy structure resistosome crystal AvrSr35. show forms homodimers are disassociated into monomers upon domain Sr35, which induces assembly...
Abstract Crystallization of biomacromolecules-metal-organic frameworks (BMOFs) allows for orderly assemble symbiotic hybrids with desirable biological and chemical functions in one voxel. The structure-activity relationship this crystal, however, is still blurred. Here, we directly identify the atomic-level structure BMOFs, using integrated differential phase contrast-scanning transmission electron microscopy, cryo-electron microscopy x-ray absorption fine techniques. We discover an obvious...
Abstract Rational integration of native enzymes and nanoscaffold is an efficient means to access robust biocatalyst, yet remains on-going challenges due the trade-off between fragile harsh assembling conditions. Here, we report a supramolecular strategy enabling in situ fusion into porous crystal. A c2-symmetric pyrene tecton with four formic acid arms utilized as building block engineer this hybrid biocatalyst. The decorated afford tectons high dispersibility minute amount organic solvent,...
Simultaneously manipulating multiple physical fields plays an important role in the increasingly complex integrated systems, aerospace equipment, biochemical productions, etc. For on-chip systems with high integration level, precise and efficient control of propagation electromagnetic waves heat fluxes simultaneously is particularly important. In this study, we propose a graphical designing method (i.e., thermal-electromagnetic surface transformation) based on null medium to thermal...
Abstract The constant emergence of SARS-CoV-2 variants continues to impair the efficacy existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved epitope targeted by broad-spectrum antibody BA7535, demonstrates high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta Omicron BA.1-BA.5, but also more recently emerged subvariants, including BF.7, CH.1.1, XBB.1,...
Abstract Utilizing covalent organic framework (COF) as a hypotoxic and porous scaffold to encapsulate enzyme (enzyme@COF) has inspired numerous interests at the intersection of chemistry, materials, biological science. In this study, we report convenient scheme for one‐step, aqueous‐phase synthesis highly crystalline enzyme@COF biocatalysts. This facile approach relies on an ionic liquid (2 μL imidazolium liquid)‐mediated dynamic polymerization mechanism, which can facilitate in situ...
Acaryochloris marina is a unique cyanobacterium using chlorophyll d (Chl ) as its major pigment and thus can use far-red light for photosynthesis. Photosystem II (PSII) of A. associates with number prochlorophyte Chl-binding (Pcb) proteins to act the light-harvesting system. We report here cryo-electron microscopic structure PSII-Pcb megacomplex from at 3.6-angstrom overall resolution 3.3-angstrom local resolution. The organized tetramer consisting two PSII core dimers flanked by sixteen...
Allostery is the phenomenon in which a ligand binding at one site affects other sites same macromolecule. has important roles many biological processes. Theoretically, all nonfibrous proteins are potentially allosteric. However, few allosteric have been validated, and identification of novel remains challenge. The motion residues subunits underlies protein function; therefore, we hypothesized that motions orthosteric correlated. We utilized data set 24 known from 23 monomer to calculate...
Abstract Background and Aims An increase in root hair length density the development of arbuscular mycorrhiza symbiosis are two alternative strategies most plants to root–soil surface area under phosphorus (P) deficiency. Across many plant species, mycorrhization inversely correlated. Root architecture, rooting physiology also differ between species. This study aims understand relationship among hairs, mycorrhizal fungi (AMF) colonization, growth, P acquisition mycorrhizal-specific Pi...
Abstract Since December 2019, the outbreak of Coronavirus Disease 2019 (COVID-19) spread from Wuhan, China to world, it has caused more than 87,000 diagnosed cases and 3,000 deaths globally. To fight against COVID-19, we carried out research for near native SARS-CoV-2 report here our preliminary results obtained. The pathogen SARS-CoV-2, was isolated, amplified purified in a BSL-3 laboratory. whole viral architecture examined by transmission electron microscopy (both negative staining...