A5052289205- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Genetic and phenotypic traits in livestock
- Pharmaceutical and Antibiotic Environmental Impacts
- Protist diversity and phylogeny
- Parasitic infections in humans and animals
- Phytoplasmas and Hemiptera pathogens
- Genetic diversity and population structure
- Insect and Pesticide Research
- Yersinia bacterium, plague, ectoparasites research
- Advanced biosensing and bioanalysis techniques
- Amoebic Infections and Treatments
Huaian First People’s Hospital
2025
Nanjing Medical University
2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Beijing Tian Tan Hospital
2018-2024
Capital Medical University
2018-2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Xi'an Jiaotong University
2012-2024
Sichuan Agricultural University
2024
N6-methyladenosine (m6A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved regulation of memory formation and mammalian cortical neurogenesis. However, while now established that m6A methylation occurs a spatially restricted manner, its functions specific brain regions still await elucidation. We identify widespread dynamic RNA developing mouse cerebellum further uncover distinct features continuous temporal-specific across...
N 6 -methyladenosine (m A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite relatively high m A levels brain, its potential functions brain remain largely unexplored. We performed a transcriptome-wide methylation analysis using mouse to depict region-specific profile. RNA cerebellum are generally higher than those cerebral cortex. Heterogeneity of exists across different regions types neural cells including mRNAs be...
Multiple myeloma (MM) is one of hematological malignancies, characterized by malignant proliferation plasma cells. Biomarkers play an important role in evaluating the development and prognosis MM. Ubiquitin-conjugating enzyme E2T (UBE2T) served to connect with particular E3 ubiquitin ligase degraded-related substrates, contributing DNA repair Fanconi anemia pathway. Also, numerous evidences reported that UBE2T closely related cell carcinogenesis. However, relationship between MM has not been...
Dorper sheep ( Ovis aries ) (DPS), developed in the 1930s by crossing Dorset Horn and Blackhead Persian South Africa, is a world-famous composite breed for mutton production. The genetic basis underlying this yet to be elucidated. Here, we report sequencing assembly of highly contiguous genome via integration Oxford Nanopore Technology (ONT) Hi-C (chromatin conformation capture) approaches. assembled was around 2.64 Gb with contig N50 73.33 Mb 140 contigs total. More than 99.5% sequences...
The evolutionary direction of gonochorism and hermaphroditism is an intriguing mystery to be solved. special transient hermaphroditic stage makes the little yellow croaker (Larimichthys polyactis) appealing model for studying hermaphrodite formation. However, origin relationship between L. polyactis Larimichthys crocea, most famous commercial fish species in East Asia, remain unclear. Here, we report sequence genome, which found ~706 Mb long (contig N50 = 1.21 scaffold 4.52 Mb) contains...
Abstract Genomic structural variants (SVs) constitute a significant proportion of genetic variation in the genome. The rapid development long‐reads sequencing has facilitated detection long‐fragment SVs. There is no published study to detect SVs using long‐read data from sheep. We applied mapping approach and characterized total 30,771 insertions, deletions, inversions translocations. identified 716, 916, 842 303 specific Southdown sheep, Alpine merino Qilian White Tibetan sheep Oula...
<title>Abstract</title> Background Recent studies have demonstrated that patients with stage IB-IIIA non-small cell lung cancer (NSCLC) harboring EGFR mutations (EGFRm) can significantly benefit from adjuvant therapy EGFR-TKIs. Nevertheless, there is remains controversial in clinical practice about the use of EGFR-TKI for IB EGFRm NSCLC. Methods This retrospective cohort study was conducted at Second Xiangya Hospital Central South University. From January 2011 to December 2020, completely...
Oxidative stress and inflammatory responses play crucial roles in the development of secondary brain injury following traumatic (TBI). Thus, this study aimed to investigate potential cerebroprotective effects salvianolic acid B (SalB) mitigating oxidative post-TBI through activation Nrf2. This aims SalB ameliorating TBI by activating Nrf2, thereby laying a foundation for treatment. Controlled cortical impact hydrogen peroxide were employed replicate animal cellular models,...
Recent studies have demonstrated that patients with stage IB-IIIA non-small cell lung cancer (NSCLC) harboring EGFR mutations (EGFRm) can significantly benefit from adjuvant therapy EGFR-TKIs. Nevertheless, there remains controversial in clinical practice about the use of EGFR-TKI for IB EGFRm NSCLC. This retrospective cohort study was conducted at Second Xiangya Hospital Central South University. From January 2011 to December 2020, completely resected IA-IB NSCLC (8th TNM staging) sensitive...
N6‑methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are to serve crucial roles in metabolism. However, role of m6A during B‑cell development tumorigenesis remains poorly understood. By analyzing gene expression profile 123 mantle cell lymphoma cases from Gene Expression Omnibus database, present study demonstrated that one‑half were able predict patient survival lymphoma, notably m6A.index....
Abstract Acute myeloid leukemia (AML) is a malignant hematological disease in which nearly half have normal cytogenetics. We tried to find some significant molecular markers for this part of the cytogenetic AML, hopes provide benefit diagnosis, typing and prognosis prediction AML patients. In present study, we calculated compared gene expression profiles cytogenetically acute (CN-AML) patients database The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) dataset Vizome (a total 632...
Multiple myeloma (MM) is the plasma cell tumor, which characterized by clonal proliferation of tumor cells, with high risk progression to renal impairment, bone damage and amyloidosis. Although survival rate patients MM has improved in past decade, most people inevitably relapse. The treatment prognosis are still urgent problems. Breast Cancer Antiestrogen Resistance 3 (BCAR3) a protein-coding gene that associated many tumors. However, there have been few studies on relationship BCAR3 MM. We...
Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, malignant clonal stem cells (LSCs). Nearly half adult AML patients exhibit cytogenetic normal acute (CN-AML). The expression level NCALD gene was associated with the prognosis ovarian cancer non-small cell lung (NSCLC). still unclear AML. We integrated 5 independent datasets totally 665 (497 CN-AML patients) to analyzed relation between clinical FAB classification,...
Exosome complex (EXOSC) genes, which encode a multi-protein intracellular complex, mediate the degradation of various types RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, primarily 3' to 5'mRNA degradation. However, how EXOSC genes are implicated processes B-cell immune-associated pathways tumorigenesis remains unclear. The present bioinformatics study indicated that 6 10 particularly EXO.index, were able predict survival...
Multiple myeloma (MM) is one of the most common incurable malignancies in malignant plasma cell disease. EPB41L4A a target gene for Wnt/β-catenin pathway, which closely related to survival multiple cells. However, there currently no research report on prognostic significance MM.
Plasma cell myeloma (PCM) secretes monoclonal immunoglobulin (Ig) by clonal plasma cells of abnormal proliferation in the bone marrow. As PCM is incurable, it necessary to find new biomarkers predict prognosis and recurrence PCM. The relationship between cancer RBBP8 has not been fully studied. role tumorigenesis remains inconsistent. We described expression gene profile 1930 samples (1878 patients) from seven independent data sets. analyzed survival prognosis, recurrence, treatment response...
ACTL10 is a member of the actin family; however, despite previous studies suggesting that certain proteins in this family may be related to pathogenesis leukemia, best our knowledge, no date have demonstrated any association between ACTAL10 and leukemia.Thus, present study aimed determine expression levels, DNA methylation levels clinical prognosis cytogenic normal acute myeloid leukemia (CN-AML).Data from seventy-five patients with CN-AML AML treated chemotherapy or allogeneic hematopoietic...
Objective: Diffuse Large B-Cell Lymphoma (DLBCL) is a common and frequently occurring subtype of Non-Hodgkin (NHL). The effective treatment prognosis DLBCL are still urgently needed to be explored. This article aims shed light on the connection between survival NR3C1 expression levels. Methods: First, we divided 952 patients into an high-expression group low-expression compared baseline characteristics two groups. Second, used multivariate analysis predict dependent variable for age,...
Multiple myeloma is a hematological tumor with malignant proliferation of cells.Although the survival time after treatment has improved, recurrence rate MM still high.Choroideremia-like (CHML) protein essential for prenylation modification various Rab proteins and it exerts biological effects on vesicle trafficking signal transduction.However, little identified about relationship between CHML gene MM.We integrated expression profiles 1907 patients (1959 samples) from 7 datasets.The level...
Marmots are large ground squirrels, and 14 species have been reported in the world, including four of marmots (Himalayan marmot, Tarbagan gray marmot long-tailed marmot) living China. Although these biological resources abundant China, information regarding their genetic features is lacking, hampering further study them. The aims this research were to evaluate variations Chinese wild marmots, analyzed kinship populations. In current study, we collected samples effective allele number, gene...
BACKGROUND: Nearly half of adult acute myeloid leukemia (AML) patients were classified into cytogenetic normal (CN-AML). The expression level Trophinin associated protein (TROAP) was proven to be with the prognosis several cancers, but it is still unclear in CN-AML. METHODS: We integrated CN-AML patient samples from 4 datasets analyze relationship between TROAP and survival In addition, we investigated 92 AML Cancer Genome Atlas (TCGA) database received chemotherapy. drug sensitivity cell...