A5057171333- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Health and Risk Factors
- Multiple Myeloma Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Menopause: Health Impacts and Treatments
- Fungal Infections and Studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Biomarkers in Disease Mechanisms
- Nail Diseases and Treatments
- Obsessive-Compulsive Spectrum Disorders
- Eicosanoids and Hypertension Pharmacology
- Genetic factors in colorectal cancer
- Acute Myocardial Infarction Research
- Inflammatory mediators and NSAID effects
- Cancer Mechanisms and Therapy
- Amyotrophic Lateral Sclerosis Research
- Toxin Mechanisms and Immunotoxins
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plant Pharmacodynamics Research
- Economic and Financial Impacts of Cancer
- Cerebrovascular and Carotid Artery Diseases
China Medical University
2024
Peking University Shenzhen Hospital
2024
Jining First People's Hospital
2024
Tianjin Medical University
2024
First Hospital of China Medical University
2024
Lanzhou University Second Hospital
2021-2023
Lanzhou University
2021-2023
Tianjin Medical University General Hospital
2016-2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
This study aims to evaluate the efficacy and safety of JAK inhibitors in treatment patients with RA.
Objective In the double-blind, phase III, placebo-controlled RUBY randomized clinical trial, dostarlimab plus carboplatin-paclitaxel significantly increased survival among patients with primary advanced or recurrent endometrial cancer (EC). We conducted a cost-effectiveness analysis of in combination chemotherapy these stratified by mismatch repair-deficient (dMMR) and repair-proficient (pMMR) subgroups from perspective United States payer. Materials methods A Markov model three states was...
This study assessed the cost-effectiveness of atezolizumab in combination with chemotherapy for patients advanced or recurrent endometrial cancer (EC) from U.S. payer's perspective.
To assess the cost-effectiveness of pembrolizumab in combination with chemotherapy compared to alone, based on results NRG-GY018 trial, patients advanced or recurrent endometrial cancer (EC), stratified by mismatch repair-deficient (dMMR) and repair-proficient (pMMR) subgroups.
Abstract Background Serum neurofilament light chain (sNfL) has been identified as a biomarker for neurologic diseases. However, sNfL remains unknown to be responsible depression. Aims The aim of this research was explore the relationship between levels and depression in US adults. Methods In cross-sectional survey general population, we investigated representative data involving 10,175 participants from 2013–2014 cycle National Health Nutrition Examination Survey (NHANES). Depression...
Acute myeloid leukemia (AML) is a heterogeneous disease in terms of genetic basis, clinical, biological and prognostic, malignant clonal stem cells (LSCs). Nearly half adult AML patients exhibit cytogenetic normal acute (CN-AML). The expression level NCALD gene was associated with the prognosis ovarian cancer non-small cell lung (NSCLC). still unclear AML. We integrated 5 independent datasets totally 665 (497 CN-AML patients) to analyzed relation between clinical FAB classification,...
Plasma cell myeloma (PCM) secretes monoclonal immunoglobulin (Ig) by clonal plasma cells of abnormal proliferation in the bone marrow. As PCM is incurable, it necessary to find new biomarkers predict prognosis and recurrence PCM. The relationship between cancer RBBP8 has not been fully studied. role tumorigenesis remains inconsistent. We described expression gene profile 1930 samples (1878 patients) from seven independent data sets. analyzed survival prognosis, recurrence, treatment response...
OBJECTIVE To explore the influence of controlling nutritional status (CONUT) score on prognosis newly diagnosed patients with multiple myeloma (MM). METHODS The clinical data 119 MM who were according to international diagnostic criteria in Lanzhou University Second Hospital from April 2010 October 2018 collected and retrospectively analyzed. relationship between indexes, including age, sex, type, absolute lymphocyte count (ALC), neutrophil (ANC), monocyte (AMC), hemoglobin (Hb), platelet...
Objective Exploring changing trends in the burden caused by overweight and obesity among children adolescents from 1990 to 2019 at global, regional, national levels, based on data Global Burden of Disease study (GBD) 2019. Methods The annual number rate deaths disability-adjusted life years (DALYs) associated with a high BMI levels age groups, sexes, sociodemographic index were collected GBD Change percentage for number, estimated changes (EAPCs) calculated determine temporal trends. Results...
Objective: Patients with acute coronary syndrome due to multivessel disease (MVD) were at the highest risk of adverse cardiovascular events. Neutrophil lymphocyte ratio (NLR) was proposed as a marker risk. Present study evaluated independent predictive value NLR for myocardial infarction (AMI) patients MVD. Methods: AMI MVD (n=1 433) underwent percutaneous intervention (PCI) between January 2013 and December followed up 2 years. divided into sub-groups based on an optimal cut off predict...
To explore the effects of prognostic nutritional index (PNI) combined with D-dimer on prognosis patients newly diagnosed diffuse large B-cell lymphoma (DLBCL).The clinical data 73 DLBCL at initial diagnosis were retrospectively evaluated, and optimal cut-off point PNI determined by ROC curve. The overall survival (OS) rate progression-free (PFS) in different subgroups compared using Kaplan-Meier curves. Univariate multivariate Cox regression analysis was performed to identify factors...
Background: The concept of cost-effectiveness is crucial for the optimal allocation scarce healthcare resources. However, entrectinib in ROS1 fusion-positive non-small cell lung cancer (NSCLC) has not been evaluated. We aim to evaluate as a first-line treatment compared its reservation second-line therapy or exclusive use chemotherapy advanced NSCLC. Methods: A Markov model was created assess clinical outcomes and costs associated with these three approaches. Cost utility values were...
Based on the social-ecological model, this study aimed to comprehensively explore factors affecting risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women provide theoretical bases for further prevention and intervention women.Postmenopausal who underwent medical examinations one health-checkup agency Tianjin from May 2015 October were enrolled study. The ICVD 10-year Risk Assesment Form developed by research team National "Tenth Five-Year Plan" project was used assess ICVD....
To observe the relationship between ATP-binding cassette subfamily B member 1 (ABCB1) and cytochrome P450 (CYP)2C19 polymorphisms effect of clopidogrel post percutaneous coronary intervention in patients with artery disease.A total 300 consecutive acute syndrome undergoing selected General Hospital People's Liberation Army from October 2010 to August 2012 treated were enrolled retrospectively analyzed. Antiplatelet responsiveness was estimated by thrombelastograph. The divided into 3 groups:...
Objective To investigate the cognition of depression and anxiety recognition physical mental illness, analyze their correlation in hospitalized elderly patients with chronic diseases. Methods A cross-sectional study was performed. A total 206 diseases from a hospital were investigated using mini state examination (MMSE), Hamilton rating scale (HAMD), self (SAS) questionnaire. Results The scores (5.95±3.05) (4.92±3.20). The correct rate disease (97±8)%, illness (47±29)%....
Abstract Objective Based on the social-ecological model, this study aimed to comprehensively explore factors affecting risk of ischemic cerebrovascular disease (ICVD) in postmenopausal women provide theoretical bases for further prevention and intervention women. Methods Postmenopausal who underwent medical examinations one health-checkup agency Tianjin from May 2015 October were enrolled study. The ICVD 10-year Risk Assesment Form developed by research team National "Tenth Five-Year Plan"...
To investigate the significance of a new risk stratification model (R2-ISS) in evaluating prognosis newly diagnosed multiple myeloma (MM).Clinical data 116 MM patients admitted to Lanzhou University Second Hospital from June 2012 March 2021 were retrospectively analyzed. According R2-ISS, these divided into four groups: low risk, low-intermediate intermediate-high and high risk. The R2-ISS on was analyzed.Survival analysis showed that associated with progression-free survival (PFS) (P=0.042)...
Abstract Background: Despite substantial improvement in chronic total occlusions (CTO) revascularization technique, the long-term clinical outcomes diabetic patients with revascularized CTO remain controversial. Our study aimed to investigate five-year cardiovascular survival for or without type 2 diabetes mellitus (DM) who underwent successful percutaneous coronary intervention (PCI) CTO. Methods: Data of current analysis derived from a large single-center, prospective and observational...
Whether infection of Cryptococcus causes disease in host or not depends on the virulence pathogen and immune defense ability host. neoformans (C. neoformans) mainly opportunistic infections immunocompromised immunodeficient patients. In contrast, gattii gattii) attacks immunocompetent individuals. On one hand, cells can eliminate invasive through a complex mechanism; other evade clearance by adopting various strategies (immune escape). This review focuses pathogenic mechanism Cryptococcus,...