A5102727094- Barrier Structure and Function Studies
- Natural product bioactivities and synthesis
- Food Quality and Safety Studies
- Bioactive Compounds in Plants
- Ginger and Zingiberaceae research
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Glutathione Transferases and Polymorphisms
- Teratomas and Epidermoid Cysts
- Ginseng Biological Effects and Applications
- Histone Deacetylase Inhibitors Research
- Morinda citrifolia extract uses
- Kruppel-like factors research
- Phytochemical and Pharmacological Studies
- NF-κB Signaling Pathways
- Phytoestrogen effects and research
- Phytochemistry and biological activity of medicinal plants
- Saffron Plant Research Studies
- Advances in Cucurbitaceae Research
- Tea Polyphenols and Effects
- Bryophyte Studies and Records
Kyungsung University
2024
Daegu Haany University
2013-2015
Dong-Eui University
2008-2010
University of Maryland, Baltimore
2008
To study the effects of [6]-gingerol, a ginger phytochemical, on tight junction (TJ) molecules, we investigated TJ tightening and signal transduction pathways in human pancreatic duct cell-derived cancer cell line PANC-1. The following methods were utilized: MTT assay to determine cytotoxicity; zymography examine matrix metalloproteinase (MMP) activities; transepithelial electrical resistance (TER) paracellular flux for measurement; RT-PCR immunoblotting proteins related invasion; EMSA NF- κ...
Bupleurum falcatum L. is employed in oriental medicine Korea. This root has been used for anti-inflammatory, anti-pyretic, and anti-hepatotoxic effects the treatments of common cold, fever, hepatitis. One major bioactive compounds Radix Bupleuri saikosaponin a (SSNa). However, little known concerning SSNa on obesity associated with state low-grade inflammation. Consequently, this study was conducted to determine inhibition inflammation pathway obesity. MTT assay cytotoxicity viability;...
β-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in variety of human cancer cells vitro and vivo; however, its mechanism action needs to be further elaborated. In this study, we investigated the effects on induction apoptosis gastric carcinoma AGS cells. significantly inhibited cellular proliferation, some typical characteristics such as chromatin condensation an increase population sub-G1 hypodiploid were observed β-lapachone-treated Treatment with...
The aim of the present study was to identify anti-inflammatory and anti-oxidative effects peat moss aqueous extract (PME) on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. To demonstrate antioxidant PME, levels nitric oxide (NO) cytokines were measured using Griess reagent cytokine ELISA kits, respectively. Reverse transcriptase-polymerase chain reaction (RT-PCR) western blot analysis conducted evaluate expression genes proteins. Immunofluorescence used measure translocation...
Sargassum horneri, an edible marine brown alga, is typically distributed along the coastal seas of Korea and Japan. Although several studies have demonstrated anti-oxidative activity this regulatory mechanisms not yet been defined. The aim present study was to examine cytoprotective effects S. horneri against oxidative stress-induced cell damage in C2C12 myoblasts.
We tested the correlation between tightness of tight junctions (TJs) and anti-invasive activity ethyl alcohol extract Hizikia fusiforme (EHF) in Hep3B human hepatocarcinoma cells. EHF inhibited cell proliferation, motility, invasiveness, which were associated with increased TJ tightness, as demonstrated by an increase transepithelial electrical resistance. dose-dependently decreased secretion matrix metalloprotease-2 -9, correlated a decrease mRNA protein expression, but tissue inhibitor...
열대아시아 원산의 다년생 초본 생강의 주성분인 [6]-gingerol은 항산화 및 항염증 등의 특성이 잘 알려져 있지만 cerulein 유도 급성췌장염에서의 자가분해 관련 유전자 발현 조절과 효소 활성에 대한 연구는 거의 없다. 본 연구에서는 급성췌장염 동물모델에서 [6]-gingerold의 작용을 조사하였다. 유발 전 4일 동안 [6]-gingerol (0.1 mg/20 g mouse/day)을 경구투여 한 후 <TEX>$50{\mu}g/kg$</TEX> cerulein을 복강주사로 급성 췌장염을 유도하였다. 그 결과 혈중 <TEX>${\alpha}$</TEX>-amyase 활성, 표적 유전자(Beclin-1 cleaved LC3-II)의 발현, 지질과산화는 투여군에서 유의적으로 감소하였으며, 항산화지표 효소인 SOD와 GSH-Px 활성은 증가하였다. 이상의 결과들은 천연식물소재 유효성분 중 하나인 [6]-gingerol이 췌장염에서 감소된 항산화효소 활성을 강화하는 효과를...
lipoprotein receptor and inhibited the accumulation activity of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. Phosphorylation AMP-activated protein kinase was stimulated by Palmiwon. In menopausal hyperlipidemic rats, Palmiw on reduced retroperitoneal peri-renal fat accumulation, serum lipids, atherogenic index, cardiac risk factors, intima-media thickness, nonalcoholic steatohepatitis scores relative to control rats. Conclusion:These results indicated that Palmiwon inhibits lipid...
We investigated whether overexpressed claudin‐3 and ‐4, a component of tight junctions (TJs), repressed invasion activity in MCF‐7 MDA‐MB 231, when treated with genistein. Genistein inhibited the cancer cell growth tightened TJs these cells as demonstrated increase transepithelial electrical resistance decreased paracellular permeability mannitol. The activities MMP‐2 ‐9 were by treatment genistein occurred time dependent manner. Those observed strong compared those MMP‐9 both lines protein...