A5049276892- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Fungal Biology and Applications
- Immune Response and Inflammation
- Seaweed-derived Bioactive Compounds
- Spectroscopy and Chemometric Analyses
- Bioactive Compounds and Antitumor Agents
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemicals and Antioxidant Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Bioactive natural compounds
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Biosensors and Analytical Detection
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Flavonoids in Medical Research
- Endoplasmic Reticulum Stress and Disease
- Food Quality and Safety Studies
- Sirtuins and Resveratrol in Medicine
- Retinoids in leukemia and cellular processes
Jeju National University
2016-2025
Georgia Institute of Technology
2025
Korea National Institute of Health
2015-2025
Duke University
2025
Hanyang University
2006-2024
Korea Institute of Geoscience and Mineral Resources
2024
Korea University of Science and Technology
2024
Boeing (Australia)
2002-2024
Kyung Hee University
2019-2024
Catholic University of Korea
2004-2023
The plasma jet has been proposed as a novel therapeutic method for anticancer treatment. However, its biological effects and mechanism of action remain elusive. Here, we investigated cell death underlying molecular mechanisms, using air N2 jets from micro nozzle array. Treatment with or caused apoptotic in human cervical cancer HeLa cells, simultaneously depolarization mitochondrial membrane potential. In addition, the were able to generate reactive oxygen species (ROS), which function...
Pathologic hyperreactive inflammatory responses occur when there is excessive activation of a proinflammatory NF-κB pathway and reduced cytoprotective NRF2 cascade. The noncytotoxic, highly selective COX-2 inhibitory flavonol-enriched butanol fraction (UaB) from Uvaria alba (U. alba) was investigated for its modulating potential by targeting activity. Enzyme-linked immunosorbent assay initially performed to measure levels mediators [nitric oxide (NO), prostaglandin E2, reactive oxygen...
Abstract Curcumin has been shown to exhibit anti-inflammatory, antimutagenic, and anticarcinogenic activities. However, the effect of curcumin on maturation immunostimulatory function dendritic cells (DC) largely remains unknown. In this study, we examined whether can influence surface molecule expression, cytokine production, their underlying signaling pathways in murine bone marrow-derived DC. DC were derived from marrow used as immature or LPS-stimulated mature cells. The tested for...
Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression pathogenesis various diseases. Glutathione is a major antioxidant that can help prevent process through removal ROS. The aim this study was evaluate protective effect glutathione on ROS-mediated DNA damage apoptosis caused by hydrogen peroxide, H₂O₂, in RAW 264.7 macrophages investigate role nuclear factor erythroid 2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway....
In most bacteria, various jumping genetic elements including insertion sequences (IS elements) cause a variety of rearrangements resulting in harmful effects such as genome and recombinant plasmid instability. The stability host is critical for high-level production proteins, this regard, the development an IS element-free strain could be useful strategy enhanced proteins. Corynebacterium glutamicum, which workhorse industrial-scale biomolecules also has several elements, it necessary to...
Cordycepin is the main functional component of Cordyceps species, which has been widely used in traditional Oriental medicine. This compound possesses many pharmacological properties, such as an ability to enhance immune function, well antioxidant, antiaging, and anticancer effects. In present study, we investigated anti-inflammatory effects cordycepin using a murine macrophage RAW 264.7 cell model. Our data demonstrated that suppressed production proinflammatory mediators nitric oxide (NO)...
Runt domain transcription factor 3 (RUNX3) is a tumor suppressor that silenced in cancer via hypermethylation of its promoter. This study investigated the mechanisms involved reactive oxygen species (ROS)-induced silencing RUNX3 terms epigenetic alteration since effects oxidative stress gene are largely unknown. mRNA and protein expressions were down-regulated response to hydrogen peroxide (H(2)O(2)) human colorectal cell line SNU-407. down-regulation was abolished with pretreatment ROS...
This study was conducted to develop a simple, rapid, and accurate lateral flow immunoassay (LFIA) detection method for point-of-care diagnosis. The one-dot LFIA aflatoxin B1 (AFB1) based on the modified competitive binding format using competition between AFB1 colloidal gold-AFB1-BSA conjugate antibody sites in test zone. A Smartphone-based reading system consisting of Samsung Galaxy S2 Smartphone, reader, Smartphone application image acquisition data analysis. limit is 5 μg/kg. provided...
Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation oxidation. However, its mechanisms of action on anti-inflammatory antioxidant effects have not been fully elucidated. In this study, the potential spermidine for reducing pro-inflammatory oxidative in lipopolysaccharide (LPS)-stimulated macrophages zebrafish was explored. Our data indicate significantly inhibited production mediators such as nitric oxide...
We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest cycle and apoptosis. Genistein down-regulated levels cyclin A B1, but up-regulated p21WAF1/CIP1, cyclin-dependent kinase (Cdk) inhibitor, that was complexed with Cdc2 Cdk2. Furthermore, activation caspases (caspase-3, -8 -9), cleavage poly (ADP-ribose) polymerase cleavage. However, genistein-induced...