A5071763411- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Cell death mechanisms and regulation
- Phytochemistry and Biological Activities
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
- Genomics, phytochemicals, and oxidative stress
- Ginseng Biological Effects and Applications
- Bioactive Compounds and Antitumor Agents
- Immune Response and Inflammation
- interferon and immune responses
- Phytochemicals and Antioxidant Activities
- Pediatric health and respiratory diseases
- RNA Interference and Gene Delivery
- Bioactive natural compounds
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Sphingolipid Metabolism and Signaling
- Cholesterol and Lipid Metabolism
- Asthma and respiratory diseases
- Lipid metabolism and biosynthesis
- Ferroptosis and cancer prognosis
- Seaweed-derived Bioactive Compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Korea Research Institute of Bioscience and Biotechnology
2013-2024
Jeju National University
2009-2010
Keimyung University
2010
Pusan National University
2007-2009
Jeju National University Hospital
2009
G-protein coupled receptor 43 (GPR43) serves as a for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 remains unclear. Here, we show that β-arrestin 2 mediates internalization of by agonist. Agonism reduced phosphorylation nuclear translocation factor-κB (NF-κB), which was relieved short interfering RNA (siRNA) 2. Subsequently, mRNA expression proinflammatory cytokines,...
The recently defined type of cell death ferroptosis has garnered significant attention as a potential new approach to cancer treatment owing its more immunogenic nature when compared with apoptosis. Ferroptosis is characterized by the depletion glutathione (GSH)/glutathione peroxidase-4 (GPx4) and iron-dependent lipid peroxidation. Diplacone (DP), geranylated flavonoid compound found in Paulownia tomentosa fruit, been identified have anti-inflammatory anti-radical activity. In this study,...
Abstract Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces cell death in various types of cancer cells but has little or no effect on normal cells. Human hepatoma are resistant to TRAIL-induced apoptosis. Although butein is known mediate anticancer, anti-inflammatory, and antioxidant activities, about the mechanism terms apoptosis human In this study, we determined that enhances through upregulation DR5. Luciferase analysis showed a 5′-flanking region containing four...
Rotundifuran (RF), a potent anti-inflammatory and anti-cancer compound, is natural compound predominantly present in Vitex Rotundifolia. Herein, we investigated the effects of RF on growth lung cancer cells. Our findings suggested that inhibits cell growth, highlighting its potential as therapeutic agent for treatment. Interestingly, observed inhibition was not due to apoptosis, caspases were activated DNA fragmentation did occur. Furthermore, found intracellular vacuoles autophagy induced,...
Allergic asthma is a major health burden on society as chronic respiratory disease characterized by inflammation and muscle tightening around the airways in response to inhaled allergens. Daphne kiusiana Miquel medicinal plant that can suppress allergic airway inflammation; however, its specific molecular mechanisms of action are unclear. In this study, we aimed elucidate which D. inhibits inflammation. We evaluated anti-inflammatory effects ethyl acetate (EA) fraction compound, daphnetin,...
beta-Ionone (ION), an end-ring analogue of beta-carotenoid, has been known to inhibit tumor cell growth and induce apoptosis in various types cancer cells. Nevertheless, its apoptosis-related molecular mechanisms remain unclear. Here, we first investigated the by which ION sensitizes cells therapeutic potential necrosis factor-related apoptosis-inducing ligand (TRAIL). Notably, treatment with subtoxic concentrations TRAIL effectively inhibited viability hepatocellular carcinoma line Hep3B...