A5056282207- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Sesquiterpenes and Asteraceae Studies
- Bioactive natural compounds
- Seaweed-derived Bioactive Compounds
- Phytochemical compounds biological activities
- Echinoderm biology and ecology
- Marine and coastal plant biology
- Botany and Geology in Latin America and Caribbean
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Coastal wetland ecosystem dynamics
- Genomics, phytochemicals, and oxidative stress
- Plant Toxicity and Pharmacological Properties
- Click Chemistry and Applications
- Nitrogen and Sulfur Effects on Brassica
- Plant chemical constituents analysis
- Plant biochemistry and biosynthesis
- Phytochemistry Medicinal Plant Applications
- Botanical Research and Applications
- Plant Growth Enhancement Techniques
- Morinda citrifolia extract uses
GEOMAR Helmholtz Centre for Ocean Research Kiel
2014-2023
Pathologic hyperreactive inflammatory responses occur when there is excessive activation of a proinflammatory NF-κB pathway and reduced cytoprotective NRF2 cascade. The noncytotoxic, highly selective COX-2 inhibitory flavonol-enriched butanol fraction (UaB) from Uvaria alba (U. alba) was investigated for its modulating potential by targeting activity. Enzyme-linked immunosorbent assay initially performed to measure levels mediators [nitric oxide (NO), prostaglandin E2, reactive oxygen...
Seagrass ecosystems provide crucial ecosystem services for coastal environments and were shown to reduce the abundance of pathogens linked infections in humans marine organisms. Among potential drivers, seagrass phenolics released into seawater have been pathogen suppression, but involvement microbiome has not investigated. We hypothesized that eelgrass Zostera marina, especially leaf epiphytes are at direct interface between host surrounding seawater, inhibit waterborne thereby contributing...
Abstract Six new ( 2 , 4 – 8 ) and two known polyketides with a basic structure of an anthraquinone‐xanthone were isolated from mycelia culture broth the fungus Engyodontium album strain LF069. The structures relative configurations these compounds established by spectroscopic means, their absolute defined mainly comparison quantum chemical TDDFT calculated experimental ECD spectra. Compounds given trivial names engyodontochone A B–F ). 5 represent first example 23,28 seco‐beticolin carbon...
Inhibition of the major cyclic adenosine monophosphate-metabolizing enzyme PDE4 has shown potential for discovery drugs cancer, inflammation, and neurodegenerative disorders such as Alzheimer's disease. As a springboard to explore new anti-cancer anti-Alzheimer's chemical prototypes from rare Annonaceae species, present study evaluated anti-PDE4B along with antiproliferative anti-cholinesterase activities extracts Philippine endemic species Uvaria alba using in vitro assays framed resulting...
The metabolism of seaweeds depends on environmental parameters, the availability nutrients, and biotic/abiotic stresses; therefore, their chemical composition fluctuates throughout year. This study investigated seasonal variations in metabolome Baltic Sea brown alga Fucus vesiculosus its potential relation to bioactivity profile. By using a definitive screening design (DSD) combined with pressurised liquid extraction (PLE), an optimised protocol was developed extract algal biomass monthly...
The main objective of the present study was to assess effects sulfur (S) nutrition on plant growth, overall quality, secondary metabolites, and antibacterial radical scavenging activities hydroponically grown lettuce cultivars. Three cultivars, namely, Pazmanea RZ (green butterhead, V1), Hawking multi-leaf lettuce, V2), Barlach (red multi-leaf, V3) were subjected two S-treatments in form magnesium sulfate (+S) or chloride (−S). Significant differences observed under −S treatments, especially...
The isolation and structure elucidation of malettinins A–C (1–3) along with the new malettinin E (4) are described. compounds were produced by fungus Cladosporium sp. strain KF501, which was isolated from German Wadden Sea. built up tropolone/dihydropyran ring structures linked to a furan ring. achieved means one- two-dimensional NMR spectroscopy supported mass UV data. relative configuration 4 determined on basis single-crystal X-ray diffraction analysis. 1–4 exhibited antibacterial...
A new member of the Flavobacteriales was isolated from surface a stone collected on German North Sea shore. The bacterium, strain ANORD5T, is mesophilic, chemoheterotrophic aerobic, typical marine bacterium. Optimal growth observed at 20–30 °C, pH 7.0–8.5 and 1–2 % sea salt. 16S rRNA gene sequence revealed distant relationship with representatives Cryomorphaceae , less than 90 similarity. Strain ANORD5T forms cluster together Owenweeksia hongkongensis UST20020801T (89.9 %), Cryomorpha ignava...
The oleoresin of Copaifera reticulata Ducke, Fabaceae, is a traditional Brazilian remedy used for wide range applications. Commonly named copaiba, the has been found to exhibit strong antimicrobial effects in our previous study, which could be attributed some its diterpenoid constituents. In order find new biological activities and eventually enhance before observed effects, (-)-polyalthic acid (1) kaurenoic (2), together with eight prepared semi-synthetic derivatives (1a-1c 2a-2e) were...
Dissolved organic matter (DOM) occupies a huge and uncharted molecular space. Given its properties, DOM can be presented as promising biotechnological resource. However, research into bioactivities of is still in early stages. In this study, the potential terrestrial marine DOM, composition their relationships are investigated. Samples were screened for vitro antibacterial, antifungal, anticancer antioxidant activities. Antibacterial activity was detected against Staphylococcus aureus almost...
Vouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well medicinal purposes. Despite frequent use, phytochemical investigations have been limited rather focused on ecological properties than pharmacological potential. In this study, we investigated phytochemistry bioactivity of V. stem bark extract constituents to identify eventual lead structures further drug development. Applying hydrodistillation subsequent...
Aims: To evaluate the in vitro antiproliferative, anticholinesterase and anti-phosphodiesterase activities of sub-extracts Uvaria alba (family Annonaceae) explore putative binding mechanisms its chemical constituents silico. Main methods: U. sub-extracts, obtained by solvent-solvent partition, were subjected to antiproliferative cytotoxicity screening against chronic myelogenous leukemia (K-562) human cervical cancer (HeLa) cells, respectively. Inhibitory assays acetylcholinesterase (AChE)...
The majority of marine natural products (MNPs) originate from tropical and temperate shallow water invertebrates, such as sponges [1]. Recent studies indicate the presence great genetic diversity in deep-waters that may be linked to unprecedented chemistry due evolution/adaptation extremely harsh environmental conditions. However, only less than 2% MNPs derive deep-sea organisms [2]. Antarctic ecosystems are rich biodiversity [3] exposed unique characteristics resulting communities...
Abstract Novel engyodontochones A (I) and B (II) show potent inhibitory activity against methicillin‐resistant Staphylococcus aureus.
Abstract Seagrass ecosystems provide crucial ecosystem services for coastal environments and were shown to reduce the abundance of pathogens linked infections in humans marine organisms. Among several potential drivers, seagrass phenolics released into seawater have been suggested play role pathogen suppression, but involvement microbiome such effect has not studied. Here we hypothesized that eelgrass Zostera marina , especially leaf epiphytes are at direct interface between host surrounding...
Onychomycosis caused by, e.g., Trichophyton rubrum or Candida albicans is the most common human nail disease with a worldwide prevalence of more than 10%. The therapeutic efficacy topical antimycotics for treatment onychomycosis proved to be inadequate in numerous studies on patients. main reasons are, above all, poor bioavailability active ingredients compartment, causing requirement extremely long application periods and correspondingly high demands adherence by patient. In present study,...
The oleoresin of Brazilian Copaifera reticulata (Fabaceae) is traditionally used for the treatment skin and urinary tract infections, respiratory diseases, rheumatism, ulcer tumors. Thus, playing an important role in primary health care indigenous population [1],[2].
Aims: To evaluate the in vitro antiproliferative, anticholinesterase and anti-phosphodiesterase activities of sub-extracts Uvaria alba (family Annonaceae) explore putative binding mechanisms its chemical constituents silico. Main methods: U. sub-extracts, obtained by solvent-solvent partition, were subjected to antiproliferative cytotoxicity screening against chronic myelogenous leukemia (K-562) human cervical cancer (HeLa) cells, respectively. Inhibitory assays acetylcholinesterase (AChE)...
<div>Aims: To evaluate the in vitro antiproliferative, anticholinesterase and anti-phosphodiesterase activities of sub-extracts Uvaria alba (family Annonaceae) explore putative binding mechanisms its chemical constituents silico. <br></div><div><br></div><div>Main methods: U. sub-extracts, obtained by solvent-solvent partition, were subjected to antiproliferative cytotoxicity screening against chronic myelogenous leukemia (K-562) human cervical...
Hyperreactive inflammatory response occurs when there is excessive activation of NF-κB leading to a pathologic cascade reactions. Thus, we investigated the modulating potentials Philippine medicinal endemic plant Uvaria alba. ELISA was initially performed measure levels proinflammatory mediators (NO and PGE 2 ) cytokines (TNF-α, IL-1β IL-6), followed by RT-PCR western blotting determine mRNA protein expression, respectively. Using immunofluorescence staining combined with blot analysis,...