A5031570285- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Chemical synthesis and alkaloids
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Phytoestrogen effects and research
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Phytochemistry and biological activity of medicinal plants
- Plant and fungal interactions
- Plant chemical constituents analysis
- Biochemical Analysis and Sensing Techniques
- Carbohydrate Chemistry and Synthesis
- Genomics, phytochemicals, and oxidative stress
- Aldose Reductase and Taurine
- Plant tissue culture and regeneration
- Traditional Chinese Medicine Analysis
- Botanical Research and Chemistry
- Metabolomics and Mass Spectrometry Studies
- Biological Stains and Phytochemicals
Kiel University
2018-2024
HAW Hamburg
2023-2024
Universität Hamburg
2023-2024
University of Vienna
2010-2014
Universität Innsbruck
2009-2014
Innsbruck Medical University
2014
Plant metabolite profiling reveals the diversity of secondary or specialized metabolites in plant kingdom with its hundreds thousands species. Specialized constitute a vast class chemicals posing significant challenges analytical chemistry. In order to be maximum scientific relevance, reports dealing these compounds and their source species must transparent, make use standards reference materials, based on correctly traceably identified material. Essential aspects qualitative include: (i)...
Today, the medicinal use of wormwood (Artemisia absinthium) is enjoying a resurgence popularity. This study presents specific and validated high-performance liquid chromatography (HPLC)−diode array detection method for simultaneous determination quantification bioactive compounds in commercial preparations thereof. Five sesquiterpene lactones, two lignans, polymethoxylated flavonoid were baseline separated on RP-18 material, using solvent gradient consisting 0.085% (v/v) o-phosphoric acid...
The genus Leontopodium, mainly distributed in Central and Eastern Asia, consists of ca. 34–58 different species. European Leontopodium alpinum, commonly known as Edelweiss, has a long tradition folk medicine. Recent research resulted the identification prior unknown secondary metabolites, some them with interesting biological activities. Despite this, nearly nothing is about Asian species genus. In this study, we applied proton nuclear magnetic resonance (1H NMR) spectroscopy liquid...
Abstract Polyamines are important metabolites in plant development and abiotic biotic stress responses. Copper-containing amine oxidases (CuAOs) involved the regulation of polyamine levels cell. CuAOs oxidize primary amines to their respective aldehydes hydrogen peroxide. In plants, intermediates various biosynthetic pathways alkaloids. thought polyamines at only one amino groups, a process frequently resulting monocyclic structures. These have been postulated be pyrrolizidine alkaloid (PA)...
Novel antiretroviral drugs are constantly needed for human immunodeficiency virus (HIV)/acquired syndrome (AIDS) patients to confront the continuously emerging resistance commonly prescribed combination of anti-HIV synthetic agents and their side effects. Amazonian medicinal plants, Licania macrophylla (LM) (Chrysobalanaceae) Ouratea hexasperma (OH) (Ochnaceae), were assayed immunomodulatory activity, by utilizing an established leukocyte cell line simian (SIV). Interleukin (IL)-4, IL-6,...
Black cohosh (Actaea racemosa) is a frequently used herbal remedy for the treatment of mild climacteric symptoms. In present study, modulation γ-aminobutryic acid (GABA)-induced chloride currents (I(GABA)) through GABA type A (GABA(A)) receptors by black extracts and isolated compounds was investigated. GABA(A) receptors, consisting α(1), β(2), γ(2S) subunits, were expressed in Xenopus laevis oocytes, potentiation I(GABA) measured using two-microelectrode voltage clamp technique....
As a continuation of investigating Impatiens L. genus, eight flavonoids, eriodyctiol, eriodyctiol 7-O-β-ᴅ-glucoside, kaempferol 3-O-β-ᴅ-glucoside, 3-O-β-ᴅ-galactoside, 3-rhamnosyl-di-glucoside, 3-O-β-ᴅ-rutinoside, quercetin 3-O-β-ᴅ-glucoside and two phenolic acids – p-hydroxybenzoic acid protocatechuic acid, 2-methoxynaphthalene-1,4-dione were isolated from the aerial parts I. glandulifera collected in Poland. The structures compounds established by analysis their spectroscopic (1H 13C NMR)...
In our continuing search for new cytotoxic agents, we assayed extracts, fractions, and pure compounds from damiana (Turnera diffusa) against multiple myeloma (NCI-H929, U266, MM1S) cell lines. After a first liquid-liquid solvent extraction, the ethyl acetate layer of an acetone (70%) crude extract was identified as most active fraction. Further separation fraction led to isolation naringenin (1), three apigenin coumaroyl glucosides 2⁻4, five flavone aglycones 5⁻9. Naringenin (1)...
The oleoresin of Copaifera reticulata Ducke, Fabaceae, is a traditional Brazilian remedy used for wide range applications. Commonly named copaiba, the has been found to exhibit strong antimicrobial effects in our previous study, which could be attributed some its diterpenoid constituents. In order find new biological activities and eventually enhance before observed effects, (-)-polyalthic acid (1) kaurenoic (2), together with eight prepared semi-synthetic derivatives (1a-1c 2a-2e) were...
In the present work, a fast and simple method for separation purification of triterpene saponins from Actaea racemosa was successfully established. Accelerated solvent extraction used defatting extracting subaerial parts, giving enriched crude extract. Size exclusion chromatography to separate actein 23-epi-26-deoxyactein other triterpenoids, which were collected in third fraction. This most complex fraction applied high-speed countercurrent chromatography, well-established technique...
Hop-derived compounds have been subjected to numerous biomedical studies investigating their impact on a wide range of pathologies. Isomerised bitter acids (isoadhumulone, isocohumulone and isohumulone) from hops, used in the brewing process beer, are known inhibit members aldo-keto-reductase superfamily. Aldo-keto-reductase 1B10 (AKR1B10) is upregulated various types cancer has reported promote carcinogenesis. Inhibition AKR1B10 appears be an attractive means specifically treat...
Black cohosh is a well-established medicinal plant and preparations of its rootstock are used for the treatment mild climacteric complaints. The compounds considered responsible therapeutic effect triterpene glycosides, characterized by cycloartane scaffold pentose moiety. Because some these triterpenoids were found to exhibit relevant cytotoxic effects against human breast cancer cells, we decided investigate their activity on multiple myeloma cell lines NCI-H929, OPM-2, U266. In systematic...
The antimicrobial properties of herbs from Papaveraceae have been used in medicine for centuries. Nevertheless, mutual relationships between the individual bioactive substances contained these plants remain poorly elucidated. In this work, phytochemical composition extracts aerial and underground parts five species (Chelidonium majus L., Corydalis cava (L.) Schweigg. Körte, C. cheilanthifolia Hemsl., pumila (Host) Rchb., Fumaria vaillantii Loisel.) were examined using LC-ESI-MS/MS with a...
Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, products containing such therefore readily consumed. In the present work, we isolated 13 phenolic of four different compound classes from aerial parts Moldavian dragonhead, an aromatic medicinal with a high diversity on secondary metabolites. All compounds were tested apoptotic effect myeloma (KMS-12-PE) AML (Molm-13) cells, highest activity observed flavone flavonol derivatives....
The herb of Trigonella caerulea (Fabaceae), commonly known as blue fenugreek, is used for the production traditional cheese and bread varieties in Alpine region. Despite its frequent consumption, only one study so far has focused on constituent pattern revealing qualitative information some flavor-determining constituents. However, with regard to volatile constituents present herb, applied methods were insufficient did not take relevant terpenoids into account. In study, we analyzed...