A5081841062- Privacy-Preserving Technologies in Data
- Hops Chemistry and Applications
- Medical Imaging Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Artificial Intelligence in Healthcare and Education
- AI in cancer detection
- Advanced MRI Techniques and Applications
- Autopsy Techniques and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Lipid metabolism and biosynthesis
- Aldose Reductase and Taurine
- Data Quality and Management
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Cardiac Imaging and Diagnostics
- Chromatography in Natural Products
- Biomedical Text Mining and Ontologies
- Topic Modeling
- Natural Products and Biological Research
- Chemotherapy-induced organ toxicity mitigation
Universität Hamburg
2024-2025
German Centre for Cardiovascular Research
2025
University Medical Center Hamburg-Eppendorf
2024-2025
Abstract Objectives Assessment of myocardial strain by feature tracking magnetic resonance imaging (FT-MRI) in human fetuses with and without congenital heart disease (CHD) using cardiac Doppler ultrasound (DUS) gating. Methods A total 43 (gestational age 28–41 weeks) underwent dynamic MRI at 3 T. Cine balanced steady-state free-precession was performed fetal DUS FT-MRI analyzed dedicated post-processing software. Endo- epicardial contours were manually delineated from 4-chamber views,...
Xanthohumol (XN), a prenylated chalcone unique to hops (Humulus lupulus) and two derived prenylflavanones, isoxanthohumol (IX) 8-prenylnaringenin (8-PN) gained increasing attention as potential anti-diabetic cancer preventive compounds. Two enzymes of the aldo-keto reductase (AKR) superfamily are notable pharmacological targets in therapy (AKR1B10) treatment diabetic complications (AKR1B1). Our results show that XN, IX 8-PN potent uncompetitive, tight-binding inhibitors human aldose AKR1B1...
Abstract Purpose Federated training is often challenging on heterogeneous datasets due to divergent data storage options, inconsistent naming schemes, varied annotation procedures, and disparities in label quality. This particularly evident the emerging multi-modal learning paradigms, where dataset harmonization including a uniform representation filtering options are of paramount importance. Methods DICOM-structured reports enable standardized linkage arbitrary information beyond imaging...
Federated learning (FL) is a renowned technique for utilizing decentralized data while preserving privacy. However, real-world applications often involve inherent challenges such as partially labeled datasets, where not all clients possess expert annotations of labels interest, leaving large portions unlabeled unused. In this study, we conduct the largest federated cardiac CT imaging analysis to date, focusing on datasets ($n=8,124$) Transcatheter Aortic Valve Implantation (TAVI) patients...
Hop-derived compounds have been subjected to numerous biomedical studies investigating their impact on a wide range of pathologies. Isomerised bitter acids (isoadhumulone, isocohumulone and isohumulone) from hops, used in the brewing process beer, are known inhibit members aldo-keto-reductase superfamily. Aldo-keto-reductase 1B10 (AKR1B10) is upregulated various types cancer has reported promote carcinogenesis. Inhibition AKR1B10 appears be an attractive means specifically treat...
Purpose: Federated training is often hindered by heterogeneous datasets due to divergent data storage options, inconsistent naming schemes, varied annotation procedures, and disparities in label quality. This particularly evident the emerging multi-modal learning paradigms, where dataset harmonization including a uniform representation filtering options are of paramount importance. Methods: DICOM structured reports enable standardized linkage arbitrary information beyond imaging domain can...