A5100687249- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Respiratory Support and Mechanisms
- Cellular Mechanics and Interactions
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
Fudan University
2016-2025
Zhongshan Hospital
2016-2025
Nanjing Medical University
2024-2025
Wuxi People's Hospital
2024-2025
Zhejiang University
2024-2025
Ministry of Education of the People's Republic of China
2012-2025
Sun Yat-sen University
2012-2024
Fudan University Shanghai Cancer Center
2023-2024
Cancer Institute (WIA)
2012-2024
State Key Laboratory of Genetic Engineering
2020-2024
The aim is to diagnose COVID-19 earlier and improve its treatment by applying medical technology, the "COVID-19 Intelligent Diagnosis Treatment Assistant Program (nCapp)" based on Internet of Things. Terminal eight functions can be implemented in real-time online communication with "cloud" through page selection key. According existing data, questionnaires, check results, diagnosis automatically generated as confirmed, suspected, or suspicious 2019 novel coronavirus (2019-nCoV) infection. It...
Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) identified as a novel immunometabolic target by using bioinformatic algorithm based on multiple HCC datasets. PGAM1 highly expressed associated with poor prognosis response to immunotherapy. In vitro vivo experiments indicate that targeting inhibited cell...
Physical forces drive the movement of tissues within early embryo. Classical and modern approaches have been used to infer and, in rare cases, measure mechanical properties location magnitude embryos. Elongation dorsal axis is a crucial event vertebrate development, yet mechanics driving embryonic elongation that later support neural tube closure formation central nervous system not known. Among vertebrates, amphibian embryos allow complex physical manipulation are required tissues. In this...
A novel system is developed for high-throughput multiplexed biomarker detection in single extracellular vesicles.
Pleural effusion (PE) is commonly observed in advanced lung cancer and was suggested to contain both cell-free tumor DNA cells. Molecular profiling of PE represents a minimally invasive approach detecting driver mutations for clinical decision making, especially when tissues are not available. The objective this study investigate the efficacy precision gene alterations samples address feasibility use. Methods: Sixty-three metastatic patients with (n=30, cohort 1) or without (n=33, 2) matched...
N6-methylation of adenosine (m6A) is one the most frequent chemical modifications in eukaryotic RNAs and plays a vital role tumorigenesis progression. Recently, emerging studies have shown that m6A modification by ALKBH5 was associated with immunotherapy response various types cancer. However, whether demethylases participate regulating tumor immune microenvironment efficacy glioblastoma remain unknown. Here, we found deletion significantly inhibited growth glioma allografts, rescued...
Numerous studies have demonstrated limited survival benefits of transarterial chemoembolization (TACE) alone in the treatment intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria. The advent immunotherapy, particularly immune checkpoint inhibitors (ICIs), has opened new avenues for HCC treatment. However, TACE combined with ICIs not been investigated patients study aims to evaluate efficacy and safety this strategy such patients. In single-arm, prospective, phase II...
Forces generated within the embryo during convergent extension (CE) must overcome mechanical resistance to push head away from rear. As increases more than eightfold CE and can vary twofold individual individual, we have proposed that developmental programs include accommodation in order maintain robust morphogenesis. To test this idea investigate processes generate forces early embryos, developed a novel gel-based sensor report force production as tissue changes shape; find mean stress...
Heart failure with preserved ejection fraction (HFpEF) is a morbid, fatal, and common syndrome for which lack of evidence-based therapies. Salvianolic acid A (SAA), major active ingredient Salvia miltiorrhiza Burge, has shown potential to protect against cardiovascular diseases. This study aims elucidate whether SAA possessed therapeutic activity HFpEF explore the mechanism. mouse model was established infusing combination high-fat diet (HFD) Nω-nitro-L-arginine methyl ester (L-NAME) 14...
During morphogenesis, forces generated by cells are coordinated and channeled the viscoelastic properties of embryo. Microtubules F-actin considered to be two most important structural elements within living accounting for both force production mechanical stiffness. In this paper, we investigate contribution microtubules stiffness converging extending dorsal tissues in Xenopus laevis embryos using cell biological, biophysical embryological techniques. Surprisingly, discovered that...
Abstract Autophagy, a type II programmed cell death, is essential for survival under stress, e.g . lung injury, and bone marrow‐derived mesenchymal stem cells ( BM ‐ MSC s) have great potential therapy. However, the mechanisms underlying activation of autophagy to provide therapeutic effect in ischaemia/reperfusion‐induced injury IRI ) remain unclear. Thus, we investigate following transplantation with s. Seventy mice were pre‐treated s before they underwent surgery vivo Human pulmonary...
Background: Calcitonin gene-related peptide (CGRP) is a neuropeptide distributed in bone tissue involved remodeling. Previously we demonstrated that CGRP can promote proliferation and migration of endothelial cells, relating to the expression vascular growth factor (VEGF) focal adhesion kinase (FAK). Methods: CGRP1 receptor human umbilical vein cells (HUVECs) was examined by immunofluorescence microscopy real-time PCR. Tube formation measured Matrigel tube assay. VEGF protein mRNA levels...
Abstract Background Chromodomain helicase DNA-binding protein 4 (CHD4) has been shown to contribute DNA repair and cell cycle promotion; however, its roles in cancer initiation progression remain largely unknown. This study aimed demonstrate the role of CHD4 development non-small lung (NSCLC) determine potential mechanisms action. Methods By using immunohistochemistry, expression levels were evaluated both non-cancerous tissues. Subsequently, knockdown overexpression strategies employed...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of failure with extremely high mortality few effective treatments. Mesenchymal stem cells (MSCs) may reportedly contribute to tissue repair in ALI ARDS. However, applications MSCs have been restricted due safety considerations limitations terms large-scale production industrial delivery. Alternatively, the MSC secretome has considered promising for use therapeutic approaches advanced pre-clinical clinical...
The coexistence of chronic obstructive pulmonary disease (COPD) in lung cancer patients often correlates with a poor clinical outcome regardless tumor stage, mainly due to older age, function, and complex comorbid disease. Emerging data suggest that the pathogenesis both diseases involves aberrant immune functioning. We conducted this retrospective study describe impact COPD on outcomes treated immunotherapy investigate potential prognostic factors.In total, 156 advanced-stage who received...
Sorafenib was first approved as the standard treatment for advanced hepatocellular carcinoma (HCC). Despite providing an advantage in terms of patient survival, sorafenib has shown poor clinical efficacy and severe side effects after long-term treatment. Thus, combination is a potential way to increase effectiveness reduce dose-limiting toxicity sorafenib. Extracts seeds Annona montana have synergistic antitumor activity with sorafenib, seven annonaceous acetogenins, including three new...
Background: Glucocorticoids (GCs) are the most potent anti‐inflammatory agents available for allergic diseases including asthma, which routinely believed to need several hours take effect through regulating gene expression. Our previous report had shown that GCs could inhibit asthma within 10 min, classical mechanism not explain. Objective: To confirm existence and verify sites of GCs’ rapid action, we investigated nongenomic effects on degranulation mast cells in asthma. Methods: The action...
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells mediate inflammatory responses in OSA‐related diseases. To determine their roles CIH‐induced injury, soluble RAGE (sRAGE), the neutralizing antibody, was intravenously administered a CIH model. We also evaluated effect of sRAGE...
BACKGROUND The authors built a model for lung cancer diagnosis previously based on the blood biomarkers progastrin‐releasing peptide (ProGRP), carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC), and cytokeratin 19 fragment (CYFRA21‐1). In current study, they examined whether modification of to include relevant clinical information, risk factors, low‐dose chest computed tomography screening would improve performance biomarker panel in large cohorts Chinese adults. METHODS study was...