A5100714460- Horticultural and Viticultural Research
- Listeria monocytogenes in Food Safety
- Fermentation and Sensory Analysis
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Bacterial biofilms and quorum sensing
- Plant biochemistry and biosynthesis
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Microbial Inactivation Methods
- Circular RNAs in diseases
- Polymer composites and self-healing
- Pharmacological Receptor Mechanisms and Effects
- ATP Synthase and ATPases Research
- Galectins and Cancer Biology
- Lipid metabolism and disorders
- Antimicrobial agents and applications
- Plant Gene Expression Analysis
- Ginseng Biological Effects and Applications
- Curcumin's Biomedical Applications
- Parasites and Host Interactions
Sichuan University
2021-2025
State Key Laboratory of Biotherapy
2024-2025
Institute of Botany
2022-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2022-2025
Zhongshan Hospital
2015-2025
Fudan University
2015-2025
State Key Laboratory of Plant Genomics
2024-2025
Beijing Botanical Garden
2024-2025
China National Botanical Garden
2024-2025
Pleural effusion (PE) is commonly observed in advanced lung cancer and was suggested to contain both cell-free tumor DNA cells. Molecular profiling of PE represents a minimally invasive approach detecting driver mutations for clinical decision making, especially when tissues are not available. The objective this study investigate the efficacy precision gene alterations samples address feasibility use. Methods: Sixty-three metastatic patients with (n=30, cohort 1) or without (n=33, 2) matched...
Oncolytic viruses (OVs) selectively replicate within tumors, directly killing cancer cells and promoting a systemic immune response by releasing tumor antigens. These features make OVs promising approach in immunotherapy, offering targeted treatment with fewer side effects. Despite these advantages, are primarily administered via intratumoral injection, limiting their effectiveness for advanced, cancers. Among OVs, oncolytic adenoviruses (oAdVs) the most widely studied due to well-understood...
Summary While specific environments are known to shape plant metabolomes and the makeup of their associated microbiome, it is as yet unclear whether carposphere microbiota contribute characteristics grape fruit flavor a particular wine region. Here, microbiomes berry transcriptomes three cultivars growing at six geographic sites were analyzed. The composition microbiome was determined mainly by environmental conditions, rather than genotype. Bacterial likely contributed volatile profiles....
Efflux is a primary fluoroquinolone resistance mechanism in Listeria monocytogenes. In the present study, ciprofloxacin resistant strains were selected by exposure of sensitive strain to progressively increasing concentrations and then roles efflux pumps Lde MdrL development also investigated L. Ciprofloxacin monocytogenes exhibited reduced susceptibility this antibiotic after induction. Cross-resistance ethidium bromide (EtBr) was observed ciprofloxacin-induced strains. However,...
Although first-line alectinib has prolonged survival in ALK-mutated non-small-cell lung cancers (NSCLCs), the response to treatment varies among patients, and primary/early development of resistance mechanisms is still not fully understood. Here, we analyzed molecular profiles 108 alectinib-treated patients (first-line second-line after crizotinib) with confirmed relapse by targeted sequencing cancer-related genes. After treatment, off-target MET NF2 alterations were more frequent than...
The mitochondrial GTPase mitofusin-2 (MFN2) gene encodes a membrane protein that can induce apoptosis of hepatocellular carcinoma (HCC) via the apoptotic pathway, as validated in our previous research. However, little is known clinical significance MFN2 expression and its signaling pathways HCC.MFN2 mRNA tumor adjacent non-tumor tissues from 115 patients with HCC was investigated using quantitative real-time PCR. association level pathological parameters evaluated statistically, while...
Microvessel density is a marker of tumor angiogenesis activity for development and metastasis. Our preliminary study showed that ginsenoside Rg3 (Rg3) induces apoptosis in hepatocellular carcinoma (HCC) vitro. The aim this was to investigate the cross-link induction antiangiogenesis effect on orthotopic HCC vivo.The murine cells Hep1-6 were implanted liver mouse. With oral feeding (10 mg/kg once day 30 days), quantitative analysis performed by using pathology transmission electron microscope...
Metastasis, a powerful prognostic indicator of oral squamous cell carcinoma (OSCC), is chiefly responsible for poor cancer outcomes. Despite an increasing number studies examining the mechanisms underlying outcomes, development potent strategies hindered by insufficient characterization crucial regulators. Long noncoding RNAs (lncRNAs) have recently been gaining interest as significant modulators OSCC metastasis; however, detailed lncRNA-mediated metastasis remain relatively uncharacterized....
Listeria monocytogenes is a major foodborne pathogen that can cause listeriosis in humans and animals. Andrographolide known as natural antibiotic exhibits good antibacterial activity. We aimed to investigate the effect of andrographolide on two quorum-sensing (QS) systems, LuxS/AI-2 Agr/AIP L. monocytogenes, well QS-controlled phenotypes this study. Our results showed neither luxS expression nor AI-2 production was affected by andrographolide. Nevertheless, significantly reduced levels agr...
Emerging evidence indicates that circular RNAs (circRNAs), which form as covalently closed loops, play a regulatory role in various types of cancer, including prostate cancer (PCa). CircSLC19A1, one kind circRNA, was subjected to the study and its PCa explored.Expressions circSLC19A1, miR-326 MAPK1 tissues cells were assessed by qRT-PCR. CircSLC19A1 identified RNase R treatment. The binding relations between circSLC19A1 predicted RegRNA2.0 or Targetscan7.2 further confirmed dual-luciferase...
The specific DNA is typically impermeable to the plasma membrane due its natural characters, but tetra structures (DTNs) can be readily uptake by cells in absence of transfection agents, providing a new strategy deliver drugs. In this research, delivery efficiency tetrahedral nanostructures was measured on adenocarcinomic human alveolar basal epithelial (A549) via delivering AS1411 (G4). tetra-AS1411 complex rapidly and abundantly A549 cells, induced apoptosis enhanced. Furthermore,...
Background Although immunotherapy can reinvigorate immune cells to clear tumors, the response rates are poor in some patients. Here, CD47 antibody-engineered oncolytic viruses (oAd-αCD47) were employed lyse tumors and activate immunity. The oAd-αCD47 induced comprehensive remodeling of tumor microenvironment (TME). However, whether acidic TME affects antitumor immunotherapeutic effects viruses-αCD47 has not been clarified. Methods To assess impact treatment on TME, we multicolor flow...
Climate change is known to simultaneously increase berry sugars but decrease anthocyanins, leading an imbalance between and anthocyanins in grape berries. To restore the balance of carbon limitation by leaf removal exogenous abscisic acid (ABA) were separately or applied Vitis vinifera cv. Cabernet Sauvignon fruit cuttings decipher their effects on quality with metabolite whole-genome transcriptome analyses. Carbon decreased hexose concentration fully blocked accumulation anthocyanins....
Introduction The distinction between multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IPM) holds clinical significance in staging, therapeutic intervention, prognosis assessment for cancer. Lineage tracing by clinicopathologic features alone remains a challenge; thus, we aimed to develop multi-omics analysis method delineating spatiotemporal heterogeneity based on tumor genomic profiling. Methods Between 2012 2022, 11 specimens were collected from two patients diagnosed...
Trichosanthes kirilowii, which is a type of Liana from cucurbitaceous family, possesses many bioactive constituents and therefore has multifarious pharmacological functions. TKP, serine protease extracted the fruit been reported to possess potential anticancer activity. However, effects TKP on cancer cell migration invasion are still unknown. Here, we that could inhibit abilities colorectal cells. In addition, mRNA, protein expression levels, activities invasion-related proteins MMP2 MMP9...