A5047328298- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Neuroendocrine Tumor Research Advances
- Vascular Malformations and Hemangiomas
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Heat shock proteins research
- Ovarian cancer diagnosis and treatment
Hunan Normal University
2016-2025
Chinese PLA General Hospital
2025
Beijing Academy of Agricultural and Forestry Sciences
2025
Institute of Plant Protection
2025
Hunan Provincial People's Hospital
2021-2025
Harbin Institute of Technology
2025
Henan University of Urban Construction
2025
Renmin Hospital of Wuhan University
2019-2024
Wuhan University
2019-2024
Ruian People's Hospital
2024
Circular RNAs (circRNAs) represent a class of endogenous noncoding that have recently been recognized as important regulators gene expression and pathological networks. However, their transcriptional activities functional mechanisms in cancer remain largely unknown. Here, we present results from global circRNA analysis patients with hepatocellular carcinoma (HCC). Using microarray, identified 226 differentially expressed circRNAs, which 189 were significantly upregulated 37 downregulated....
Pyroptosis is a newly discovered programmed cell death that associated with tumor progression, prognosis, and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in microenvironment (TME) remain unclear. We described alterations PRGs 1109 colorectal cancer (CRC) samples from genetic transcriptional fields evaluated their expression patterns four independent datasets. identified two distinct molecular subtypes found multi-layer PRG were correlated patient...
There has been a dramatic increase in the off-label use of ophthalmic timolol maleate, β-blocker used for infantile hemangioma (IH) treatment as topical counterpart to oral propranolol. Its safety and efficacy pediatric population with IH have not evaluated large cohort. Our goal was retrospectively assess timolol's effectiveness, discern characteristics associated response, document reported adverse events.A multicenter retrospective cohort study 731 patients treated completed at 9 centers....
Cortex Eucommiae is used worldwide in traditional medicine, various constituents of Eucommiae, such as chlorogenic acid (CGA), has been reported to exert anti-osteoporosis activity China, but the mechanism about their contribution overall limited. The aims this study were determine whether can prevent estrogen deficiency-induced osteoporosis and analyze CGA bioactivity. effect on was performed vivo. Sixty female Sprague-Dawley rats divided randomly among a sham-operated group five...
Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs gastric (GC) still unknown. Here, we aimed to determine regulatory mechanism GC.Expression profiles were downloaded from four Gene Expression Omnibus (GEO) microarray datasets. miRNAs mRNAs collected The Cancer Genome Atlas (TCGA) database. We used robust rank aggregation method identify differentially expressed (DEcircRNAs) a ceRNA...
Chemotherapy damages the intestinal mucosa, causing adverse gastrointestinal reactions. Clostridium butyricum (C. butyricum) reduces incidence of diarrhea in digestive diseases, including inflammatory bowel disease. Therefore, aim present study was to investigate role C. patients undergoing chemotherapy. A total 41 participants with lung cancer were enrolled, and divided into (CB) or placebo group using 1:1 randomization obtain 20 CB 21 participants. On first last day 3‑week intervention,...
Fibroblasts and macrophages play key roles in the development of hepatocellular carcinoma (HCC). However, cross-talk between these two kinds cells has not been well studied. Endosialin (CD248/TEM1) is a transmembrane glycoprotein that expressed certain cancer cells, tumor stromal pericytes. In this study, we found endosialin mainly cancer-associated fibroblasts (CAF) HCC its expression inversely correlates with patient prognosis. interacted CD68 to recruit regulated GAS6 CAFs mediate M2...
Abstract Dysregulated circular RNAs (circRNAs) contribute to tumourigenesis and cancer progression. However, the expression patterns biological functions of circRNAs in colorectal (CRC) remain elusive. Here, RNA sequencing bioinformatics analyses are applied screen for aberrantly expressed circRNAs. The circFBXW4 CRC tissues cell lines is determined by quantitative real‐time PCR. A series vitro vivo function assays implemented assess circFBXW4. regulatory mechanisms linking circFBXW4,...
Abstract The liver is the most frequent site of metastasis in colorectal cancer ( CRC ), which long noncoding RNA s (lnc s) may play a crucial role. In this study, we performed genome‐wide analysis lnc expression to identify novel targets for further study . Samples obtained from patients were analyzed using Arraystar human 8 × 60K / mRNA v3.0 microarrays chips find differentially expressed and s. results confirmed by quantitative reverse transcription‐polymerase chain reaction qRT ‐ PCR )....
The purpose of this study was to develop a nomogram predict cancer-specific survival (CSS) in pancreatic cancer (PC).We used the Surveillance, Epidemiology, and End Results (SEER) database analyze 53,028 patients diagnosed with PC from 2004 2014 randomly divided them into training (n=26,583) cohort validation (n=26,445) cohort. Univariate multivariate analyses were select independent prognostic factors. We significant factors for constructing based on Cox regression analyses. Validation...
Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, it is urgent to explore new treatments improve patient prognosis. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have exhibited remarkable activity clinical trials were approved by the FDA for therapy several types of tumors. Here, we evaluated PD-L1 expression T cell infiltration AGC. Positive tumor was detected 171 AGCs (33.60%) out 509 AGCs. positively correlated with CD8 + infiltration....
In early studies, it was shown that HINT2, which sensitizes cells to mitochondrial apoptosis, is down-regulated in hepatocellular carcinoma (HCC) (Martin et al., 2006). However, the molecular mechanism of this effect unknown. Immunohistochemistry revealed HINT2 expression relatively low pancreatic cancer tissues, compared adjacent tissues (P < 0.05). Furthermore, its related pathological grade and lymph node metastasis = 0.0161 0.0108, respectively); addition, down-regulation found be...
Background: Genetic characteristics remain underutilized for establishing prognostic models colorectal cancer (CRC). We explored the underlying regulatory mechanisms of circular RNAs (circRNAs) that act as competing endogenous (ceRNAs) and constructed a gene-based nomogram to predict overall survival (OS) in patients with CRC. Methods: obtained circRNA expression profiling data from Gene Expression Omnibus (GEO) database. MicroRNA (miRNA) mRNA profiles, associated clinical data, were The...
Long noncoding RNAs (lncRNAs) have been confirmed to be potential prognostic markers in a variety of cancers and interact with microRNAs (miRNAs) as competing endogenous (ceRNAs) regulate target gene expression. However, the role lncRNA‑mediated ceRNAs breast cancer (BC) remains unclear. In present study, ceRNA network was generated explore their BC. The expression profiles mRNAs, miRNAs lncRNAs 1,109 BC tissues 113 normal were obtained from Cancer Genome Atlas database (TCGA). A total 3,198...
Bladder cancer (BC) is a heterogeneous disease, and pyrroline‑5‑carboxylate reductase 1 (PYCR1) can promote the proliferation invasion of BC cells accelerate progression. In present study, si‑PYCR1 was loaded into bone marrow mesenchymal stem cell (BMSC)‑derived exosomes (Exos) in BC. First, PYCR1 levels tissues/cells were assessed, proliferation, invasion, migration evaluated. Aerobic glycolysis (glucose uptake, lactate production, ATP expression relevant enzymes) EGFR/PI3K/AKT pathway...
Abstract Background N6‐Methyladenosine (m6A) RNA methylation modulators are implicated in nasopharyngeal carcinoma (NPC). Circular RNAs (circRNAs) stimulate/inhibit the development of NPC by sponging microRNAs (miRNAs). Herein, m6A modifications affecting circRNA/miRNA axis were explored. Methods Twenty prognostic regulators identified from 504 head/neck squamous cell and 44 normal samples The Cancer Genome Atlas (TCGA). Differentially expressed miRNAs screened TCGA Gene Expression Omnibus...
Oxidative stress plays an important role in the pathogenesis of various liver diseases. Safflower yellow B (SYB) has been reported to protect brain against damage induced by oxidative stress; however, whether SYB can also hepatocytes from remains unknown. In present study, determine pre-treatment with reduces hydrogen peroxide (H2O2)‑induced HepG2 cells, we investigated H2O2-induced cells treated or without SYB. Cell viability was measured MTT assay and cytotoxicity evaluated lactate...