A5100452670- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Bone Metabolism and Diseases
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- dental development and anomalies
- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Lung Cancer Treatments and Mutations
- Carcinogens and Genotoxicity Assessment
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
Capital University
2025
Capital Medical University
2020-2025
Sichuan University
2018-2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
Chongqing University of Technology
2025
Anhui Medical University
2017-2025
Fujian Medical University
2025
Ministry of Education of the People's Republic of China
2025
Affiliated Hospital of Nantong University
2024
Circulating microRNAs (miRs) are differentially regulated and selectively packaged into microparticles (MPs). We evaluated whether diabetes mellitus alters circulating vascular endothelial MP-incorporated miRs expression levels. MPs were isolated from 135 patients with or without type II characterized using flow cytometer electron microscope. Nine involved in the regulation of performance—miR-126, miR-222, miR-let7d, miR-21, miR-30, miR-92a, miR-139, miR-199a miR-26a—were quantified by...
Primary Sjögren syndrome (pSS) is a systemic autoimmune disease associated with dysregulated immune cells, no efficient therapy. There need to study potential therapeutic approaches.To investigate the efficacy, safety, and response of low-dose interleukin 2 (LD-IL-2) in treatment pSS.A double-blind, placebo-controlled randomized clinical trial was conducted 2-group superiority design from June 2015 August 2017. Sixty patients, aged 18 70 years, were recruited Peking University People's...
40-50% of colorectal cancer (CRC) patients develop metastatic disease; the presence metastasis hinders effective treatment through surgery, chemotherapy and radiotherapy, which makes 5-year survival rate extremely low; therefore, studying CRC is crucial for disease therapy. In present study, we investigated role rhomboid domain containing 1 (RHBDD1) in tumor CRC.The expression RHBDD1 was analyzed 539 tissues its correlation with lymphatic distal metastasis. Transwell assay vitro pleural...
Abstract Recent studies have confirmed that microRNAs and lncRNAs can affect bone cell differentiation formation. In this study, miR-139-3p was upregulated in the femurs of hindlimb unloading mice MC3T3-E1 cells under simulated microgravity; effect related to osteoblast apoptosis. Silencing attenuated suppression promotion apoptosis induced by microgravity. ELK1 is a target essential for regulate An differentiation-related lncRNA could interact with (lncRNA ODSM) identified Further...
The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in migration, motility invasion. object this study investigate the involvement CTHRC1 NSCLC invasion metastasis.A proteomic analysis was performed identify different expression proteins between normal tissues. Cell lines stably express CTHRC1, MMP7, MMP9 were established. Invasion migration determined by scratch transwell...
Long noncoding RNAs (lncRNAs) have been confirmed to be potential prognostic markers in a variety of cancers and interact with microRNAs (miRNAs) as competing endogenous (ceRNAs) regulate target gene expression. However, the role lncRNA‑mediated ceRNAs breast cancer (BC) remains unclear. In present study, ceRNA network was generated explore their BC. The expression profiles mRNAs, miRNAs lncRNAs 1,109 BC tissues 113 normal were obtained from Cancer Genome Atlas database (TCGA). A total 3,198...
Neurofilament light (NfL) can reflect the extent of neuron/axon damage, thus providing an opportunity to examine severity and progression diseases with such damage.Whether serum NfL be used as indicator monitor cognitive progress de novo Parkinson's disease (PD) remains unclear.In this research, 144 healthy controls 301 PD patients from Progression Markers Initiative (PPMI) were recruited. Linear mixed effects models associations baseline/longitudinal decline. Cox regression was detect in...
RNA-binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming through post-transcriptional regulation of DEP domain-containing mammalian target rapamycin (mTOR)-interacting protein (DEPTOR) GC. In clinical samples, elevated expression PUM1 associated with recurrence, metastasis, poor survival. vitro vivo experiments...
Abstract Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity heterogeneity among PLCs remains challenging. Here, using single-cell RNA sequencing, spatial transcriptomic bulk multi-omics, we elaborated molecular architecture 3 PLC types, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) combined hepatocellular-cholangiocarcinoma (CHC). Taking high-resolution...
Abstract Hair loss is characterized by a shortened hair anagen phase and follicles (HF) miniaturization. Morroniside the most abundant iridoid glycoside extracted from Cornus officinalis has various bioactivities in different cell functions tissue regeneration. In this study, we investigated effects underlying mechanism of morroniside on growth regulation HF cycle transition. treatment significantly enhanced outer root sheath (ORSC) proliferation migration vitro . Additionally, upregulated...
The great importance of long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually. LncRNA LINC01857 is a novel lncRNA and reported to promote breast cancer progression. However, the biological roles glioma are not explored. In present research, levels were found be upregulated glioma. addition, expression negatively correlated with survival rate patients. Functional investigation revealed that downregulation impaired proliferation invasiveness. Furthermore, knockdown led...
Zearalenone (ZEA), a pathogenic toxin produced by Fusarium, is widely detected in moldy feed materials. Previous studies have reported that ZEA exerts harmful influence on animal reproductive systems; however, its effects the changes of long noncoding RNAs (lncRNAs) remain unclear. Here, tackling this question, we performed RNA sequencing porcine granulosa cells (GCs) after being exposed to 10 and 30 μM vitro. The results showed exposure observably changed expression lncRNAs GCs increased...
Orthodontically induced inflammatory root resorption (OIIRR) is the major iatrogenic complication of orthodontic treatment, seriously endangering tooth longevity and impairing masticatory function. Osteoclasts are thought to be primary effector cells that initiate pathological process OIIRR; however, cellular molecular mechanisms responsible for OIIRR remain unclear. Our previous studies revealed cementocytes, mechanically responsive in cementum, respond compressive stress activate influence...
Cataracts are a serious complication of diabetes. In long-term hyperglycemia, intracellular Ca2+ concentration ([Ca2+]i) and reactive oxygen species (ROS) increased. The apoptosis lens epithelial cells plays key role in the development cataract. We investigated potential for transient receptor vanilloid 2 (TRPV2) diabetic cataracts. Immunohistochemical Western blotting analyses showed that TRPV2 expression levels were significantly increased patients with cataracts as compared senile...