A5108323819- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Microbial Natural Products and Biosynthesis
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Plant Gene Expression Analysis
- Plant biochemistry and biosynthesis
- Organic Light-Emitting Diodes Research
- RNA modifications and cancer
- Wheat and Barley Genetics and Pathology
- Luminescence and Fluorescent Materials
- Organic Electronics and Photovoltaics
- Cancer-related gene regulation
- Synthetic Organic Chemistry Methods
- Ion channel regulation and function
- Biological Activity of Diterpenoids and Biflavonoids
- Lung Cancer Treatments and Mutations
- Genetic Mapping and Diversity in Plants and Animals
- Synthesis and Biological Evaluation
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Plant Stress Responses and Tolerance
- Horticultural and Viticultural Research
Qinghai University
2022-2025
Sun Yat-sen University
2016-2025
Nanjing Agricultural University
2017-2025
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Shanghai University
2015-2024
Qinghai New Energy (China)
2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2023
Centre for Sustainable Energy
2019
Shandong Maternal and Child Health Hospital
2019
Hebei University of Science and Technology
2019
The T-cell surface molecule TIGIT is an immune checkpoint that inhibits responses, but its roles in cancer are little understood. In this study, we evaluated the role plays development and progression of gastric cancer. We show percentage CD8 T cells TIGIT+ was increased patients compared with healthy individuals. These showed functional exhaustion impaired activation, proliferation, cytokine production, metabolism, all which were rescued by glucose. addition, tissue cell lines expressed...
Calcium signaling has been postulated to be critical for both heat and chilling tolerance in plants, but its molecular mechanisms are not fully understood. Here, we investigated the function of two closely related cyclic nucleotide-gated ion channel (CNGC) proteins, OsCNGC14 OsCNGC16, temperature-stress rice (
ABSTRACT Members of the cyclic nucleotide‐gated channel (CNGC) proteins are reportedly involved in a variety biotic and abiotic responses stomatal movement. However, it is unknown if how single member could regulate multiple responses. Here we characterized three closely related CNGC genes rice, OsCNGC14 , OsCNGC15 OsCNGC16 to determine whether they function stresses. The loss‐of‐function mutants each these had reduced calcium ion (Ca 2+ ) influx slower closure response heat, chilling,...
Low temperature affects seed germination in plants, and low-temperature (LTG) is an important agronomic trait. Natural variation of LTG has been reported rice, but the molecular basis for this largely unknown. Here we report phenotypic analysis 187 rice natural accessions a genome-wide association study (GWAS) collection. A total 53 quantitative trait loci (QTLs) were found to be associated with LTG, which 20 located previously QTLs. We further identified Stress-Associated Protein 16...
The interaction between CD155 and its high-affinity ligand TIGIT is being increasingly investigated in various solid tumors. However, the prognostic significance of lung adenocarcinoma (LUAD) remains unclear. In this study, immunohistochemistry was applied 334 LUAD cases to evaluate expression TIGIT. Western blotting conducted 5 paired primary adjacent normal tissues. Our results reveal that are overexpressed tissues aberrant overexpression closely correlated with poor clinical outcomes (P <...
Abstract Background WD40 transcription factors, a large gene family in eukaryotes, are involved variety of growth regulation and development pathways. plays an important role the formation MYB-bHLH-WD (MBW) complexes associated with anthocyanin synthesis, but studies Qingke barley lacking. Results In this study, 164 HvWD40 genes were identified genome analyzed to determine their relevant bioinformatics. The classified into 11 clusters 14 subfamilies based on structural phylogenetic protein...
Large-conductance voltage- and Ca 2+ -activated K + (Slo1 BK) channels serve numerous cellular functions, their dysregulation is implicated in various diseases. Drugs activating BK therefore bear substantial therapeutic potential, but deployment has been hindered part because the mode of action remains obscure. Here we provide mechanistic insight into how dehydroabietic acid derivative Cym04 activates channels. As a representative NS1619-like openers, reversibly left-shifts half-activation...
The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in migration, motility invasion. object this study investigate the involvement CTHRC1 NSCLC invasion metastasis.A proteomic analysis was performed identify different expression proteins between normal tissues. Cell lines stably express CTHRC1, MMP7, MMP9 were established. Invasion migration determined by scratch transwell...
Abstract Purpose: Examining the role of developmental signaling pathways in “driver gene–negative” lung adenocarcinoma (patients with negative for EGFR, KRAS, BRAF, HER2, MET, ALK, RET, and ROS1 were identified as gene–negative”) may shed light on clinical research treatment this subgroup. We aimed to investigate whether activation can stratify risk adenocarcinoma. Experimental Design: In discovery phase, we profiled mRNA expression each candidate gene using genome-wide microarrays 52 paired...
Decarbonylative borylation of aryl anhydrides by rhodium catalysis has been reported. A base-free system with Rh(PPh
Colored barley, which may have associated human health benefits, is more desirable than the standard white variety, but metabolites and molecular mechanisms underlying seedcoat coloration remain unclear.Here, development of Tibetan hulless barley was monitored, 18 biological samples at 3 color developmental stages were analyzed by transcriptomic metabolic assays in Nierumuzha (purple) Kunlun10 (white). A total 41 anthocyanin compounds 4186 DEGs identified. Then we constructed...
To investigate the role of HvnAnt2 gene in formation different qingke barley grain colours, was isolated from leaves White 91-97-3 (white), Blue (blue), Kunlun 17 (black), and Purple (purple). The encodes a hydrophilic unstable protein consisting 561 amino acids, without transmembrane structure signal peptide, with one bHLH-MYC_N HLH domain at acids 22–204 387–436, respectively. most closely related to Hordeum vulgare distantly Triticum monococcum; it mainly light responsiveness methyl...
Barley leaf stripe, a disease mainly caused by Pyrenophora graminea (P. graminea) infection, severely affects barley yield and quality is one of the most widespread diseases in production. However, little known about underlying molecular mechanisms stripe resistance. In this study, transcript expression profiles normal infected leaves resistant Tibetan hulless (Hordeum vulgare L. var. nudum Hook. f.) variety Kunlun 14 susceptible Z1141 were analyzed RNA sequencing (RNA-seq). The results...
ABSTRACT Grain size is an important factor affecting quinoa yield, and studying the molecular mechanism of grain formation great significance for cultivar selection. In this study, we analysed phenotypic traits, conducted RNA sequencing proteomic detection during filling in different developmental stages. As progressed, particularly middle to late stages, fresh dry weights large‐grained were 17.13%–32.57% higher than those small‐grained quinoa. Combined transcriptomic analyses performed...
The first total synthesis of the originally proposed and revised structure scleritodermin A, along with an isomer, were achieved by use alpha-azido carboxyl group serving as key alpha-ketoamide precursor, thus leading to a revision for natural A.