A5115603947- Plant nutrient uptake and metabolism
- Pharmacological Effects of Natural Compounds
- Amino Acid Enzymes and Metabolism
- Immune cells in cancer
- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Neuropeptides and Animal Physiology
- Spectroscopy and Chemometric Analyses
- Hormonal Regulation and Hypertension
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Photosynthetic Processes and Mechanisms
- Immune Cell Function and Interaction
- Pharmacogenetics and Drug Metabolism
- Plant Stress Responses and Tolerance
- Spectroscopy Techniques in Biomedical and Chemical Research
- Psoriasis: Treatment and Pathogenesis
Nanjing Agricultural University
2024-2025
Sun Yat-sen University
2017
Eighth Affiliated Hospital of Sun Yat-sen University
2017
Ningbo University
2013-2014
The T-cell surface molecule TIGIT is an immune checkpoint that inhibits responses, but its roles in cancer are little understood. In this study, we evaluated the role plays development and progression of gastric cancer. We show percentage CD8 T cells TIGIT+ was increased patients compared with healthy individuals. These showed functional exhaustion impaired activation, proliferation, cytokine production, metabolism, all which were rescued by glucose. addition, tissue cell lines expressed...
The scaffolding protein RACK1 is involved in polar auxin transport and signaling. It binds to PINOID PIN-FORMED2, enhancing their interaction phosphorylation-dependent efflux. Knocking down genes impairs auxin-related processes such as root growth gravitropic response. Auxin controls multiple developmental plant responses environmental stimuli (Adamowski Friml, 2015). plasma membrane-localized PIN-FORMED (PIN) efflux transporters govern directional cell-to-cell the gradient distribution of...
The aim of this study was to determine whether 9 genetic polymorphisms confered susceptibility schizophrenia (SCZ). authors conducted meta-analyses on associations between SCZ and variants 6 genes including PIK3C3 (432C > T), ABCB1 (C3435T G2677T), CTLA4 (+49A/G), OLIG2 (rs762178), GAD1 (rs1978340, rs3749034 rs769395), GRIN1 (G1001C). A total 34 case-control studies were involved in our meta-analyses. Our results showed no significant association all the loci SCZ. This meta-analysis...
This study introduces newly discovered chrysin derivatives that show potential as candidate molecules for treating inflammatory bowel disease (IBD). Compound 4b , among the synthesized compounds, displayed significant inhibitory effects on monocyte adhesion to colon epithelium induced by TNF-α, with an IC 50 value of 4.71 μM. Further mechanistic studies demonstrated inhibits production reactive oxygen species (ROS) and downregulates expression ICAM-1 MCP-1, key involved in...
Raman spectroscopy has become a hot research topic in the field of drug detection due to its non-destructive, rapid, non-polluting and flexible measurement methods. This article mainly summarizes excellent performance identifying new psychoactive substances, structurally similar substances trace drugs (such as metabolites blood urine living organisms) literature, demonstrates that combined with chemometrics achieves classification identification drugs, introduces application combination...