A5038176054- Lung Cancer Treatments and Mutations
- Inflammatory mediators and NSAID effects
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Occupational and environmental lung diseases
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Advanced Biosensing Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Radical Photochemical Reactions
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
Tongde Hospital of Zhejiang Province
2019-2025
Harbin Institute of Technology
2025
Beijing Institute of Education
2022-2025
Wuhan University
2015-2024
Zhongnan Hospital of Wuhan University
2016-2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2024
The University of Texas MD Anderson Cancer Center
2021-2023
University of South China
2023
Academy of Military Medical Sciences
2023
Sichuan University
2023
Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, there is an urgent need to identify the underlying mechanisms develop strategies overcome them.A homology model of human CYP4A11 was constructed using SYBYL-X 2.0. Structure-based virtual screening against COX-2, mPGES-1 CYP4A11was performed Surflex-Dock SYBYL suite. The candidates were...
Vitamin D deficiency has been linked to various inflammatory diseases in lungs, including pneumonia, asthma and chronic obstructive pulmonary disease. However, the mechanisms by which vitamin receptor reduce inflammation lung remain poorly understood. In this study, we investigated expression cell-specific distribution of tight adherens junctions lungs receptor-deficient (VDR-/-) mice. Our results demonstrated that mRNA protein levels claudin-2, claudin-4 claudin-12 were significantly...
Malignant peritoneal mesothelioma (MPeM) is a rare but aggressive malignancy with limited treatment options. VEGF inhibition enhances efficacy of immune-checkpoint inhibitors by reworking the immunosuppressive tumor milieu. Efficacy and safety combined PD-L1 (atezolizumab) (bevacizumab) blockade (AtezoBev) was assessed in 20 patients advanced unresectable MPeM progression or intolerance to prior platinum-pemetrexed chemotherapy. The primary endpoint confirmed objective response rate per...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common cancer death reasons. Anti-tumor necrosis factor-alpha (TNF-α) antibodies have shown promising effects in PDAC pre-clinical models. However, prognostic values TNF-α, underlying mechanisms by which anti-TNF-α treatments inhibit PDAC, and potential synergistic with chemotherapy are still unclear.To identify targeting TNF-α we measured expression different stages initiation evaluated its significance a pancreatic cohort. We found...
Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. The Sigma-1 (σ-1) receptor has received increasing attention in recent years because of its ability link different signaling systems exert function the brain through chaperone actions, especially neuropsychiatric disorders. YL-0919, novel σ-1 agonist developed by our institute, shown antidepressive anxiolytic effects variety animal models, but on PPD have not been revealed. In present study,...
Non-small cell lung cancer (NSCLC) is a common malignancy whose prognosis and treatment outcome are influenced by many factors. Some studies have found that tertiary lymphoid structures (TLSs) in may contribute to the prediction of immunotherapy efficacy However, combined role TLSs NSCLC remains unclear. We accessed The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases obtain mRNA sequencing data clinical information as TCGA cohort, used our own sample 53 advanced study...
Abstract Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and cytochrome P450 (CYP) 4A-mediated arachidonic acid (AA) metabolism play an essential role in human inflammatory disorders. Blocking COX-2 pathway would shunt AA to the other pathway, thereby decreasing efficacy exacerbating adverse effects. Here we demonstrated that reprogramming COX-2, 5-LOX, CYP4A-mediated macrophages by salidroside (Sal) ameliorates monosodium urate (MSU) crystal-induced inflammation. Compared with inhibitor...
Abstract Purpose: Examining the role of developmental signaling pathways in “driver gene–negative” lung adenocarcinoma (patients with negative for EGFR, KRAS, BRAF, HER2, MET, ALK, RET, and ROS1 were identified as gene–negative”) may shed light on clinical research treatment this subgroup. We aimed to investigate whether activation can stratify risk adenocarcinoma. Experimental Design: In discovery phase, we profiled mRNA expression each candidate gene using genome-wide microarrays 52 paired...
Abstract A novel distal radical rearrangement of alkoxyphosphine is developed for the first time and applied to regioselective fluoroalkylphosphorylation unactivated olefins. By employing a one‐pot two‐step reaction (bis)homoallylic alcohols, organophosphine chlorides, fluoroalkyl iodides under CFL (compact fluorescence light) irradiation, series fluoroalkylphosphorylated alkyl alcohols are easily synthesized by regiospecific installing phosphonyl onto inner carbon terminal olefins further...
The effects of isoliensinine (IL), a bisbenzylisoquinoline alkaloid extracted from the Chinese traditional medicine seed embryo Nelumbo nucifera Gaertn., on bleomycin (BLM)-induced pulmonary fibrosis in mice were investigated. Seventy-two male Kungming divided randomly into eight groups as BLM-IL10, BLM-IL20, BLM-IL40, BLM-Sal, Sal-IL10, Sal-IL20, Sal-IL40 and Sal-Sal groups. BLM (0.1 mg 0.05 ml saline per animal, once) or (0.05 was applied intratracheally, IL (10, 20, 40 mg/kg) administered...