TBAI could catalyze the direct oxidative C–N coupling of 2-aminopyridines with β-keto esters and 1,3-diones, which affords imidazo[1,2-a]pyridines as products. The reaction was realized under metal-free conditions by using tert-butyl hydroperoxide (TBHP) oxidant.

Up the tempo: The intramolecular addition of oxime radicals to CC bonds was achieved by using DEAD and TEMPO give 4,5-dihydroisoxazoles as a result CO bond-forming, 5-exo-trig cyclization. γ,δ-Unsaturated ketoximes also reacted afford cyclic nitrones through CN bond formation. reactions offer metal-free approach for vicinal difunctionalization unactivated alkenes. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not...

In this paper, we present a general protocol for the making of surface-imprinted core−shell nanoparticles via surface reversible addition−fragmentation chain-transfer (RAFT) polymerization using RAFT agent functionalized model silica as agent. protocol, trichloro(4-chloromethylphenyl)silane was immobilized on SiO2 nanoparticles, forming chloromethylphenyl (silica-Cl). subsequently produced by substitute reaction silica-Cl with PhC(S)SMgBr. The grafting copolymerization 4-vinylpyridine and...

The Cu/N-ligand/TEMPO catalytic system was first applied to the aerobic oxidative synthesis of heterocycles. As demonstrated, 2-substituted quinazolines and 4H-3,1-benzoxazines were synthesized efficiently from one-pot reaction aldehydes with 2-aminobenzylamines 2-aminobenzyl alcohols, respectively, by employing CuCl/DABCO/4-HO-TEMPO as catalysts oxygen terminal oxidant.

A novel and efficient aerobic protocol for the oxidative synthesis of 2-aryl quinazolinesviabenzyl C-H bond amination by a one-pot reaction arylmethanamines with 2-aminobenzoketones 2-aminobenzaldehydes has been carried out using 4-hydroxy-TEMPO radical as catalyst, without any metals or additives.

A convenient and versatile oxidative intra/intermolecular oxyamination diamination of unactivated alkenes has been developed through copper-catalyzed radical reactions β,γ- γ,δ-unsaturated ketoximes with electron-rich aryl aliphatic amines. These were carried out by employing di-tert-butyl peroxide (DTBP) or air as the terminal oxidant, a series useful nitrogen-containing 4,5-dihydroisoxazoles cyclic nitrones formed.

A novel iminoxyl radical-involved metal-free approach to vicinal oxyoximation and aminooximation of unactivated alkenes is developed. This method utilizes the dichotomous reactivity radical furnish a general difunctionalization on using simple tert-butyl nitrite (TBN) as initiator well carbon trap. By this protocol, oxime featured 4,5-dihydroisoxazoles cyclic nitrones were facilely prepared from β,γ- γ,δ-unsaturated ketoximes, respectively.

Abstract Hydrazonyl radicals are known for their π‐electronic structures; however, σ‐electronic structures have not been reported as yet. Herein, we show that readily accessible β,γ‐ and γ,δ‐unsaturated N ‐trichloroacetyl ‐trifluoroacetyl hydrazones can be conveniently converted into hydrazonyl σ radicals, which subsequently undergo 5‐ exo ‐trig radical cyclization at the 1 or 2 atom to form pyrazolines azomethine imines, respectively.

A 4-HO-TEMPO-catalyzed redox strategy for the synthesis of pyridines through annulation cyclopropanols and oxime acetates has been developed. This protocol features good functional group tolerance high chemoselectivity also promises to be efficient late-stage functionalization skeletons drugs natural products. Mechanism studies indicate that reaction involves in situ generated α,β-unsaturated ketones imines as key intermediates, which are derived from via a TEMPO/TEMPOH cycle, respectively....

A facile strategy has been demonstrated for the selective synthesis of highly stereoregular polyesters with cis-2,3-(exo, exo) or trans-2,3-(exo, endo) repeating units by organocatalysts mediated alternating copolymerization cyclohexene oxide and norbornene anhydride (NA) stereoisomers. The geometrical structure polyester can be tuned simply modulating type NA isomers (endo- exo-NA), monomer feed ratio, reaction temperature. cis- (>99%) trans-polyesters exhibit high glass transition...

Abstract A tunable photocatalytic method is reported for anti ‐Markovnikov hydro‐ and aminooxygenation of unactivated alkenes using readily accessible ketoxime carbonates as the diverse functionalization reagents. Mechanistic studies reveal that this reaction initiated through an energy‐transfer‐promoted N−O bond homolysis leading to alkoxylcarbonyloxyl iminyl radicals under visible‐light photocatalysis, followed by addition radical alkenes. By taking advantage different stability radicals,...

The intramolecular addition of hydrazone radicals to carbon–carbon double bonds was achieved by using TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) or DIAD (diisopropyl azodicarboxylate) as the radical initiator well carbon scavenger. Consequently, alkenes were difunctionalized afford pyrazolines and tetrahydropyridazines via C–N forming 5-exo-trig 6-exo-trig cyclizations, respectively, allyls trifunctionalized tandem 1,5-H-shift/5-exo-trig cyclizations under metal-free neutral conditions.

Readily accessible β,γ-unsaturated ketoximes reacted with 2-arylphenylisonitriles under the conditions of t-BuOOH and n-Bu4NI to give isoxazoline functionalized phenanthridines via tandem intramolecular/intermolecular C–O/C–C/C–C bond formation. The reaction involves initial generation iminoxyl radicals from oxidation by followed a cascade radical cyclization/addition/cyclization sequence.

A novel, efficient, and facile vicinal sulfonamination of alkynes by the reaction accessible 2-alkynyl arylazides with sulfinic acids in presence tert-butyl hydroperoxide (TBHP) has been developed. This protocol utilizes as sulfonating reagent, azidos aminating TBHP sulfonyl radical initiator. By using this protocol, a variety potentially bioactive 3-sulfonylindoles were facilely synthesized via direct annulation.

A novel and facile approach to vicinal oxycyanation aminocyanation of internal unactivated alkenes is developed. This method utilizes the dichotomous reactivity iminoxyl radical derived from initiation β,γ- γ,δ-unsaturated ketoximes provide general difunctionalization using tert-butyl hydroperoxide (TBHP) as environmentally friendly oxidant, CuCN commercially available cyanating reagent, pentamethyldiethylenetriamine (PMDETA) ligand. By this protocol, a series useful cyano-featured...

A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction easily accessible ketohydrazones olefins in presence 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The involves initial generation azoalkenes from direct oxidative dehydrogenation using TEMPO as commercially available oxidant, followed subsequent aza-Diels–Alder with olefins.

A novel, metal-free, and regioselective approach for the synthesis of isoxazoline/cyclic nitrone-featured methylenes has been developed by reaction readily accessible β,γ- γ,δ-unsaturated ketoximes with TEMPO via tandem iminoxyl radical-promoted cyclization/TEMPO-mediated Cope-like elimination, respectively. This protocol utilizes commercially available as radical initiator well β-hydrogen acceptor in elimination.

A novel, efficient, and facile approach for the synthesis of structurally important pyrimidines has been successfully developed by Cu-catalyzed 4-HO-TEMPO-mediated [3 + 3] annulation commercially available amidines with saturated ketones. This method provides a new protocol cascade reaction oxidative dehydrogenation/annulation/oxidative aromatization via direct β-C(sp3)-H functionalization ketones followed amidines.

A facile, mild, and efficient dioxygen activation for the synthesis of isoxazoline/cyclic nitrone-featured α-ketols has been achieved by Cu-catalyzed trifunctionalization internal unactivated alkynes unsaturated ketoximes at room temperature. 18O isotope tracing DFT calculation reveal that a cascade iminoxyl radical dichotomous 5-exo-dig cyclization/oxygen activation/peroxy 4-endo-trig cyclization process was involved in reaction.

Abstract A novel distal radical rearrangement of alkoxyphosphine is developed for the first time and applied to regioselective fluoroalkylphosphorylation unactivated olefins. By employing a one‐pot two‐step reaction (bis)homoallylic alcohols, organophosphine chlorides, fluoroalkyl iodides under CFL (compact fluorescence light) irradiation, series fluoroalkylphosphorylated alkyl alcohols are easily synthesized by regiospecific installing phosphonyl onto inner carbon terminal olefins further...

Polyesters are efficiently prepared from ROCOP of PA and epoxides with [OSSO]CrX/Lewis base binary catalyst. The VCHO-derivatized polyesters can be functionalized by a thiol-ene reaction.

A novel vicinal sulfoximation of alkenes was achieved under mild and metal-free conditions by using readily available sulfinic acids as the sulfonating agent <italic>tert</italic>-butyl nitrite (TBN) radical initiator oxime source.

An efficient and practical tandem cyclization/addition/cyclization strategy is developed for the initial generated hydrazonyl radicals derived from oxidation of β,γ-unsaturated hydrazones. By using this protocol, structurally novel pyrazoline-functionalized oxindoles are prepared by reaction easily accessible hydrazones with N-aryl acrylamides under metal- solvent-free conditions DTBP (di-tert-butyl peroxide) via a intra/intermolecular C–N/C–C/C–C bond formation.

A convenient and efficient vicinal oxyalkynylation/aminoalkynylation of internal unactivated alkenes is achieved by means a Cu-catalyzed radical cascade reaction unsaturated ketoximes with ethynylbenziodoxolone (EBX) reagents. This protocol enables the synthesis structurally valuable isoxazolines or cyclic nitrones introduction an important alkyne group in single operation. The characterized broad substrate scope for both alkynylation reagents low catalyst loading.