A5022553879- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Genetic Syndromes and Imprinting
- Congenital Anomalies and Fetal Surgery
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Ferroptosis and cancer prognosis
- Assisted Reproductive Technology and Twin Pregnancy
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Tumors and Oncological Cases
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Genomics, phytochemicals, and oxidative stress
Weifang People's Hospital
2019-2025
Yale University
2018-2024
Wuhan University
2010-2021
Zhongnan Hospital of Wuhan University
2010-2021
Beijing University of Technology
2017
Tianjin University of Science and Technology
2014-2017
BACKGROUND: Breast cancer is a common in women of worldwide. Cancer cells with stem-like properties played important roles breast cancer, such as relapse, metastasis and treatment resistance. Micro-RNA-155 (miR-155) well-known oncogeni
Shaoyao‐gancao‐tang, a Chinese medicinal formula consisting of peony and licorice has been used for the treatment dysmenorrhea thousands years. The purpose present study was to demonstrate analgesic uterine relaxant effects isoliquiritigenin (ISL), flavonoid isolated from roots Glycyrrhiza glabra (a type licorice). In vitro , caused concentration‐dependent inhibition spontaneous contraction rat uterus induced by various types stimulants, such as acetylcholine (Ach, 10 µ m ), KCl (40 )...
Hepatocellular carcinoma (HCC) is the most common solid tumor in global range, with high degree of malignancy and poor prognosis. But relationship between expression GAS5-AS1 HCC not documented. This study aimed to profile signature then explore its clinical significance HCC.Quantitative real-time PCR (RT-qPCR) was performed detect 83 pairs surgical tissues adjacent normal liver tissues. We also RT-qPCR on plasma samples 156 patients 58 healthy controls.We found that down-regulated (P<...
Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Due to the lack of early prediction marker, numerous patients were diagnosed in their late stage. The family cavins plays important roles caveolae formation and cellular processes. Cavin-2, one members cavins, has been reported as suppresser cancers. In this study, we have investigated its expression pattern clinical significance HCC. Methods: RT‑qPCR was performed detect cavin-2. Results: Cavin-2 down-regulated HCC...
Lung cancer is one of the most common causes death in world. Rhizoma paridis saponins (RPS) have been found to show inhibition pulmonary adenoma previous research. However, detailed mechanisms RPS from a holistic view not established. In this study, Lewis mice were successfully established analyze pathways involved intervening tumor formation and progression. As result, inhibited levels cytokines or receptors such as VEGFD, VEGFR3, RAGE, IL6R, IL17BR, CXCL16 which regarded initiators induced...
Aim: This study aimed to excavate the roles of BCYRN1 in hepatocellular carcinoma (HCC). Methods: A comprehensive strategy microarray data mining, computational biology and experimental verification were adopted assess clinical significance identify related pathways. Results: was upregulated HCC its expression positively associated with both tumor, node, metastasis worse survival rate patients HCC. Through combing plasma alpha fetoprotein, diagnosis remarkably improved. may regulate some...
Background: Array comparative genomic hybridization (aCGH), karyotyping and fluorescence in situ (FISH) analyses have been used a clinical cytogenetic laboratory. A systematic analysis on diagnostic findings of cytogenomic abnormalities current prenatal pediatric settings provides approaches for future improvement. Methods: retrospective was performed abnormal by aCGH, karyotyping, FISH from 3,608 cases 4,509 during 2008-2017. The accuracy evaluated comparing the abnormality detection rate...
Abstract Constitutional ring chromosome 9, r(9), is a rare chromosomal disorder. Cytogenomic analyses by karyotyping, array comparative genomic hybridization (aCGH) and whole genome sequencing (WGS) were performed in patient of r(9). Karyotyping detected mosaic pattern r(9) monosomy 9 83% 17% cells, respectively. aCGH subtelomeric deletions 407 kb at 9p24.3 884 9q34.3 an interstitial duplication 5.879 Mb 9q33.2q34.11. WGS revealed double strand breaks (DSBs) ends 9q34.3, inverted repeats...