A5044878491- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Bee Products Chemical Analysis
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Vascular Anomalies and Treatments
- Essential Oils and Antimicrobial Activity
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Insect and Pesticide Research
- Protein Interaction Studies and Fluorescence Analysis
- Surfactants and Colloidal Systems
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Inflammatory Bowel Disease
- Health and Wellbeing Research
- Proteins in Food Systems
- Nosocomial Infections in ICU
- RNA modifications and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- MicroRNA in disease regulation
- Cardiovascular and Diving-Related Complications
Fudan University
2018-2025
Zhongshan Hospital
2018-2025
Liaocheng University
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2018-2025
Sun Yat-sen University
2018-2025
Weatherford College
2021
ORCID
2020
Tokyo University of Pharmacy and Life Sciences
2019
Shandong Provincial Hospital
2016-2017
Shandong University
2016-2017
Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to artery remodeling OSA-related diseases. immunologic factors linked OSA-induced PH are not well understood. STAT6 crucial in the signaling pathway that modulates response. However, status phosphorylated (p-STAT6) an mouse model remains largely unexplored. Chronic intermittent hypoxia (CIH) plays a role progression OSA. This study...
Emerging evidence shows that signal transducer and activator of transcription 6 (STAT6) plays critical roles in tumor development. We previously found high-level expression STAT6 human lung adenocarcinoma squamous cell carcinoma, specifically infiltrated immune cells located the interstitium. Nevertheless, role signaling carcinogenesis cancer proliferation, its underlying mechanisms remain unclear. This study aimed to investigate as well interaction between microenvironment pulmonary...
Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed investigate preventive dextran sulphate sodium (DSS)-induced acute murine colitis, which mimics symptoms human ulcerative colitis (UC). Pre-treatment with (15 mg/kg, p.o.) resulted significant decreased macroscopic signs DSS-induced colitic symptoms, including...
An adverse role for obstructive sleep apnea (OSA) in cancer aggressiveness and mortality has recently emerged from clinical animal studies, the reasons have not been fully determined. Cancer stem cells (CSCs) are regarded as main cause of carcinoma metastasis. So far, relationship between OSA lung CSCs explored.
The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for anti-angiogenic effects of remain unclear. This study determined role BTB domain in angiogenesis. is highly expressed circulating endothelial cells from acute myocardial infarction patients and early induction gene ischemia. Mice were treated with adenoviruses coding GFP (AdGFP), (AdBach1), or a mutant lacking (AdBach1-ΔBTB)...
Abstract Background Growing evidence suggests that cancer stem cells (CSCs) are responsible for initiation in tumors. Bach1 has been identified to contribute several tumor progression, including lung cancer. The role of CSCs remains poorly known. Therefore, the function on was focused currently. Methods expression Bach1, CD133, CD44, Sox2, Nanog and Oct4 mRNA assessed using Real-Time Quantitative Reverse Transcription PCR (RT-qPCR). Protein Nanog, Oct4, p53, BCL2, BAX, p-p38, p-AKT1, c-Fos...
Honey adulteration is one of the most prominent issues in food production. Herein, alternating current (AC) impedance spectroscopy combined with 1H NMR profile were used to reveal adulterants acacia honey. Variation electrical parameters such as solution resistance (Rs), double layer capacitance (CD), charge transfer (RCT) and for 10%–90% (w/w) syrups or rape honey adulterated samples analyzed. We clearly demonstrate that difference AC between obvious, levels RCT are always smaller than...
Pulmonary arterial hypertension (PAH) is a critical cardiopulmonary vascular disorder marked by the progressive elevation of pulmonary artery pressure, increased resistance, and eventual right heart failure. Research has shown that various immune cells play significant role in pathogenesis PAH, both patients diagnosed with condition experimental models PAH. Cell–cell communication important for PAH progression therapies, while global cell landscape intercellular signaling not been...
Abstract Pulmonary hypertension (PH) is prevalent in patients with obstructive sleep apnea (OSA) syndrome, and coexistence of PH OSA indicates a worse prognosis higher mortality. Chronic intermittent hypoxia (CIH) the key pathogenesis OSA. Also, microRNA‐223 (miR‐223) plays role regulation CIH‐induced process. However, detailed mechanism CIH inducing still unclear. This study aimed to investigate pathological process associated explore potential therapeutic methods. In this study, adult...
Abstract Background Inflammatory bowel disease (IBD) is a chronic of the intestinal tract in which excessive activation inflammatory response correlated. Cyanidin-3-O-glucoside (C3G) powerful anti-inflammatory agent, widely existing fruits and vegetables. However, role C3G has rarely been investigated dextran sulfate sodium (DSS)–induced colitis. Methods In an attempt to elucidate possible mechanism IBD develop new efficient therapeutic methods for colitis, we evaluated effects on...
Propolis is rich in flavonoids and has excellent antitumor activity. However, little known about the potential effects of propolis on glycolysis tumor cells. Here, against human breast cancer MDA-MB-231 cells an inflammatory microenvironment stimulated with lipopolysaccharide (LPS) were investigated by assessing key enzymes glycolysis. treatment obviously inhibited cell proliferation, migration invasion, clone forming, angiogenesis. Proinflammatory mediators, including necrosis factor-alpha...
Honey adulteration has become a prominent issue in the honey market. Herein, we used fluorescence spectroscopy combined with chemometrics to explore simple, fast, and non-destructive method detect wolfberry adulteration. The main parameters such as maximum intensity, peak positions, lifetime were analyzed depicted principal component analysis (PCA). We demonstrated that position of was relatively fixed at 342 nm compared those multifloral honey. intensity decreased redshifted an increase...
Inflammatory bowel disease (IBD) including Crohn's (CD) and ulcerative colitis is a relapsing-remitting illness. Patients with long-standing extensive are easy to develop colorectal cancer (CRC). The increasing incidence of IBD substantial increase in the risk CRC make necessity pay more attention on regulation inflammation especially by specific macrophages subset. present study reported that key subset sinus macrophage expressing CD169 mesenteric lymph nodes (mLNs) played an essential role...
Background: In December of 2019, coronavirus disease 2019 (Covid-19) was reported in Wuhan, China, and has now rapidly swept around the world. Much research been carried out since outbreak, but few studies have focused on dysfunction adaptive immunity. Methods: this retrospective multi-center study, 373 patients with laboratory-confirmed COVID-19 from Shanghai Public Health Clinical Center Affiliated Hospital Putian University were recruited. Demographic, clinical, radiological features,...