A5101956701- Hormonal Regulation and Hypertension
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pulmonary Hypertension Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Cancer, Lipids, and Metabolism
- Spondyloarthritis Studies and Treatments
- Nitric Oxide and Endothelin Effects
- Advanced MRI Techniques and Applications
- Lymphatic Disorders and Treatments
- Head and Neck Cancer Studies
- Traditional Chinese Medicine Analysis
- Lymphatic System and Diseases
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Animal Virus Infections Studies
- Mercury impact and mitigation studies
- Inflammasome and immune disorders
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Mathematical Biology Tumor Growth
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
National Clinical Research
2025
National Cancer Center
2025
Stanford Medicine
2025
Hebei University of Chinese Medicine
2015-2024
Peking Union Medical College Hospital
2022-2023
Chengdu Fifth People's Hospital
2023
Weatherford College
2023
First Hospital of China Medical University
2022
China Medical University
2022
This report introduces the Qwen2 series, latest addition to our large language models and multimodal models. We release a comprehensive suite of foundational instruction-tuned models, encompassing parameter range from 0.5 72 billion, featuring dense Mixture-of-Experts model. surpasses most prior open-weight including its predecessor Qwen1.5, exhibits competitive performance relative proprietary across diverse benchmarks on understanding, generation, multilingual proficiency, coding,...
We investigated the ameliorative effects and potential mechanisms of tannic acid (TA) in carbon tetrachloride (CCl4)-intoxicated mice hepatic stellate cells (HSCs). Liver fibrosis was observed CCl4 (800 ml/kg)-induced mice, high viability (10 mM)-intoxicated HSCs. Pre-treatment with TA (25 or 50 g/kg/day) significantly ameliorated morphology coefficient values reduced activities aspartate aminotransferase (AST) alanine (ALT), concentrations malondialdehyde (MDA) serum levels endothelin-1...
Depression is a common disease that endangers people's physical and mental health. Traditional Chinese medicine has advantages in treating the emotional cognitive symptoms of depressive disorders.To study effects baicalin on behavior to clarify underlying mechanism through evaluation Rac1-LIMK1-cofilin pathway.A chronic mild stress (CMS) model depression was used. Baicalin administered mice for intervention, positive control group treated with fluoxetine. Behavioral tests were conducted...
This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and metabolism in rats.Twenty-four rats were randomly divided into CSD control (CON) groups. Rats subjected by using modified multiple platform method (MMPM) establish an animal model CSD. Biochemical parameters such as levels serum N-terminal propeptide type I procollagen (PINP), cross-linking telopeptide collagen (NTX), growth hormone (GH), estradiol (E2), 25(OH)D, calcium (Ca) evaluated at 0, 1, 2, 3...
Severe renal fibrosis often occurs in obstructive kidney disease, not only the obstructed but also contralateral kidney, causing dysfunction. Although mechanisms of injury have been studied for years, pathogenesis remains largely unknown. Here, we examined long-term unilateral ureteral obstruction (UUO) model male Sprague-Dawley rats and found that macrophage-to-myofibroblast transition (MMT) is contributing to UUO rats. Interestingly, this process was attenuated by treatment eplerenone, a...
Objective. To observe the effect of berberine (BBR) on kidney cell pyroptosis in golden hamsters with diabetic nephropathy (DN) and to explore molecular mechanism its renal protection. Methods. Fifty clean-grade male were randomly divided into a control group (10) model building (40). The DN was established by high-sugar high-fat feeding injection small amount STZ. After successful establishment model, they group, western medicine high- low-dose groups. given irbesartan 13.5 mg/kg, groups...
Renal fibrosis is the inevitable pathway of progression chronic kidney disease to end-stage renal disease, which manifests as progressive glomerulosclerosis and interstitial fibrosis. In a previous study, we observed severe in contralateral kidneys 6-month unilateral ureteral obstruction (UUO) rats, was accompanied by increased macrophage infiltration phenotypic transformation; after eplerenone administration, these effects were reduced. Therefore, hypothesized that this effect closely...
Abstract Inflammation and fibrosis often occur in the kidney after acute injury, resulting chronic disease consequent renal failure. Recent studies have indicated that lymphangiogenesis can drive inflammation injured kidneys. However, whether how this pathogenesis affects contralateral remain largely unknown. In our study, we uncovered a mechanism by which responded to injury. We found activation of mineralocorticoid receptors increase vascular endothelial growth factor C unilateral ureteral...
Abstract Background To investigate the potential of synthetic MRI (SyMRI) in prognostic assessment patients with nonmetastatic nasopharyngeal carcinoma (NPC), and predictive value when combined diffusion-weighted imaging (DWI) as well clinical factors. Methods Fifty-three NPC who underwent SyMRI were prospectively included. 10th Percentile, Mean, Kurtosis, Skewness T1, T2, PD maps ADC obtained from primary tumor. Cox regression analysis was used for analyzing association between DWI...
Renal fibrosis is an inevitable process in the progression of chronic kidney disease (CKD). Angiogenesis plays important role this process. Vascular endothelial cells are involved renal by phenotypic transformation and secretion extracellular matrix. Aldosterone stimulates mineralocorticoid receptor (MR) activation induces inflammation, which for angiogenesis. Clinically, MR blockers (MRBs) have a protective effect on damaged kidneys, may be associated with inhibition In study, we used...
Introduction. Cardiovascular disease constitutes the leading cause of mortality in patients with chronic kidney (CKD), which is termed cardiorenal syndrome type 4 (CRS-4). Here, we report development pathological cardiac remodeling and fibrosis unilateral urinary obstruction (UUO) rats. Methods. Hematoxylin eosin (H&E) staining was performed to observe pathology myocardial tissue. The degree tissue observed by Masson Sirius red staining. Immunohistochemical applied detect expression CD34...
Magnetic resonance imaging (MRI) is commonly used for the diagnosis of nasopharyngeal carcinoma (NPC) and occipital clivus (OC) invasion, but a proportion lesions may be missed using non-enhanced MRI. The purpose this study to investigate diagnostic performance synthetic magnetic (SyMRI) in differentiating NPC from hyperplasia (NPH), as well evaluating OC invasion.Fifty-nine patients with 48 volunteers who underwent SyMRI examination were prospectively enrolled. Eighteen first-order features...
Abstract Aim To describe the clinical characteristics of Chinese patients with psoriatic arthritis (PsA) using data recorded in Registry Psoriatic Arthritis (CREPAR). Methods This is a cross‐sectional study based on CREPAR registry, which prospective registry founded December 2018. Data regarding and treatment were collected during every visit. at enrollment extracted, analyzed, compared other registries or cohorts. Results A total 1074 registered from 2018 to June 2021. Of these, 929...