A5086252020- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Bone Metabolism and Diseases
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- GDF15 and Related Biomarkers
- Cancer Mechanisms and Therapy
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Peroxisome Proliferator-Activated Receptors
- Cholinesterase and Neurodegenerative Diseases
- Natural Compounds in Disease Treatment
- Neonatal and fetal brain pathology
- Circular RNAs in diseases
- Plant-based Medicinal Research
Hebei University of Chinese Medicine
2014-2025
Affiliated Hospital of Chengde Medical College
2003-2021
Hebei Chemical and Pharmaceutical College
2013-2014
Beijing University of Posts and Telecommunications
2014
Hebei Medical University
2005-2014
Chengde Medical University
2013
Fourth People's Hospital of Shenzhen
2009
Shijiazhuang University
2009
Background: Ischemia/reperfusion (I/R) caused by ischemic stroke treatments leads to brain injury, and autophagy plays a role in the pathology. Astragaloside IV is potential neuroprotectant, but its underlying mechanism on cerebral I/R injury needs be explored. The objective of this study investigate neuroprotective against injury. Methods: Middle artery occlusion method (MCAO) oxygen glucose deprivation/reoxygenation (OGD/R) were used simulate Sprague-Dawley (SD) rats HT22 cells,...
The neuropeptide cholecystokinin octapeptide (CCK-8) inhibits inflammation by downregulating the expression of proinflammatory cytokines, such as tumor necrosis factor alpha and interleukin (IL) 1beta during endotoxin shock. However, signaling mechanism CCK-8 action has not yet been clearly elucidated. In this study, we have examined possible pathways which lipopolysaccharide (LPS)-induced IL-1beta production in rat pulmonary interstitial macrophages. macrophages, LPS is known to activate...
Salmonella spp. is among the main foodborne pathogens which cause serious diseases. An isothermal real-time recombinase polymerase amplification (RPA) and lateral flow strip detection (LFS RPA) were used to detect targeting conserved sequence of invasion protein A ( invA ). The Real-time RPA was performed in a portable florescence scanner at 39°C for 20 min. LFS an incubator block 15 min, under same condition that amplifications could be inspected by naked eyes on within 5 limit DNA using...
Background: cerebral ischemia/reperfusion (I/R) injury is an important complication of ischemic stroke, and autophagy one the mechanisms it. In this study, we aimed to determine role mechanism in I/R injury. Methods: oxygen glucose deprivation/reoxygenation (OGD/R) method was used model HT22 cells. CCK-8 LDH were conducted detect viability damage cells, respectively. Apoptosis measured by flow cytometry Tunel staining. Autophagic vesicles cells assessed transmission electron microscopy....
Cerebral ischemia‑reperfusion injury (CIRI), caused by the reperfusion of blocked vessels following ischemic stroke, can lead to secondary brain injury. Throughout CIRI, apoptosis serves an important role. Astragaloside IV is a potential neuroprotectant that alleviates CIRI inhibiting apoptosis. The calcium‑sensing receptor (CaSR) G‑protein‑coupled receptor, activation which aggravates aim present study was investigate whether protective effect on may be associated with regulation CaSR. A...
Oxidative stress is widely acknowledged as a key pathogenic mechanism in diabetic nephropathy (DN). In recent years, the role of oxidative DN has garnered increasing attention. However, no bibliometric analysis yet been conducted on relationship between and DN. This study aims to systematically analyze relevant literature, identify trends research, assess current hotspots, predict future directions. We retrieved literature related from Web Science Core Collection database. analyzed data...
Mitochondria are an important organelle affecting the occurrence and development of ischemic stroke (IS). Although role mitochondria in IS has been paid attention to, relevant biomarkers have not identified, targeted treatment is still lacking. To further solve these problems, this study, we combined standardized GSE16561 GSE58294 datasets GEO database as test set, GSE22255 training set. The mitochondria-related gene set was obtained from MitoCarta3.0 for study. R language used to screen...
Background/Objectives: Periostracum Cicadae (PC) is commonly used to treat chronic atrophic gastritis (CAG), but its underlying mechanisms are unclear. We investigated the therapeutic effects, active ingredients and molecular of PC on CAG. Methods: analyzed components in serum extract by UHPLC-Q-Orbitrap-MS/MS. Then, we rat cell models assess impact CAG employed network pharmacology bioinformatics predict key targets ingredients. Finally, confirmed hub through experiments docking. Results: A...
Background: Chronic atrophic gastritis precancerous lesions (PL-CAG) are characterized by the atrophy of gastric mucosal glands, often accompanied intestinal metaplasia or dysplasia. Timely intervention and treatment can effectively reverse its malignant progression prevent onset cancer. Bombyx Batryticatus (BB) exhibits a range pharmacological effects, including anticoagulation, antiepileptic properties, anticancer activity, antibacterial effects. However, basis mechanisms underlying BB’s...
Alzheimer's disease (AD) is a neurodegenerative brain disorder and the most common cause of dementia. New treatments for AD are required due to its increasing prevalence in aging populations. The present study evaluated effects active components Epimedium, Astragalus Radix Puerariae on learning memory impairment, β‑amyloid (Aβ) reduction iron load an APPswe/PS1ΔE9 transgenic mouse model AD. Increasing evidence indicates that disturbance normal homeostasis may contribute pathology However,...
To evaluate the protective effect of Buyang Huanwu Decoction (BHD) against cerebral ischemia reperfusion and investigate whether autophagy is involved in its mechanism action.Adult male Sprague Dawley rats were randomly divided into three groups: sham, (I/R), I/R + BHD groups. A rat model injury was established via middle artery occlusion (MCAO) for 2 h, followed by 1, 3, 7 d reperfusion. Neurological scores regional blood flow assessed to determine successfully established. Brain infarct...
Background: The Buyang Huanwu decoction (BYHWD) is a traditional Chinese herbal prescription and has been used in China to treat spinal cord injury (SCI) for hundreds of years. Clinical trials have shown that BYHWD improves the outcome SCI clinical trials, but mechanisms are not known. This study observed neuroprotective effects on nerve cells after investigated possible mechanisms.Materials methods: Forty female Wistar rats were randomized equally four groups treated by sham injury, SCI,...