A5065916929- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Alzheimer's disease research and treatments
- Advanced Polymer Synthesis and Characterization
- Trace Elements in Health
- Neurobiology and Insect Physiology Research
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Erythropoietin and Anemia Treatment
- Gout, Hyperuricemia, Uric Acid
- Polymer Surface Interaction Studies
- RNA modifications and cancer
- Medicinal Plant Pharmacodynamics Research
- IL-33, ST2, and ILC Pathways
- Click Chemistry and Applications
- Glaucoma and retinal disorders
- Iron oxide chemistry and applications
- Neurological Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
- Bone Metabolism and Diseases
East China Normal University
2025
Jilin University
2022-2025
State Key Laboratory of Supramolecular Structure and Materials
2022-2025
Huizhou University
2025
Guangzhou Medical University
2025
Xinjiang Medical University
2020-2024
Tumor Hospital of Xinjiang Medical University
2020-2024
Soochow University
2024
Tianjin Medical University
2020-2024
Tianjin First Center Hospital
2020-2024
Summary Arginine decarboxylase (ADC)‐mediated putrescine (Put) biosynthesis plays an important role in plant abiotic stress response. SNF1‐related protein kinases 2s (SnRK2s) and abscisic acid (ABA)‐response element (ABRE)‐binding factors (ABFs), are core components of the ABA signaling pathway involved drought We previously reported that ADC Poncirus trifoliata ( PtrADC ) functions tolerance. However, whether how SnRK2 ABF regulate to modulate accumulation under remains largely unclear....
Reversible deactivation radical polymerization (RDRP) is a set of powerful and versatile methods for the synthesis well-defined polymers. Over past two decades, engagement biocatalysts, namely, enzymes bacteria, has granted distinctive features to RDRP propelled toward more sustainable future. In this Perspective, we highlight green conditions, oxygen tolerance, function, ability access difficult polymers in conducted by biocatalysis (bio-RDRP), discuss major considerations when conducting...
Pseudomonas aeruginosa causes serious acute and chronic infections in humans. Major differences exist disease pathogenesis, clinical treatment outcomes between infections. P. infection characteristically involves the type III secretion systems (T3SS) while is often associated with formation of biofilms, a major cause difficulties to eradicate The choice or switch them by controlled regulatory pathways that control virulence factors genes biofilm formation. In this study, we characterized...
AlgR is a key transcriptional regulator required for the expression of multiple virulence factors, including type IV pili and alginate in Pseudomonas aeruginosa. However, regulon molecular regulatory mechanism have yet to be fully elucidated. Here, among 157 loci that were identified by ChIP-seq assay, we characterized gene, mucR, which encodes an enzyme synthesizes intracellular second messenger cyclic diguanylate (c-di-GMP). A ΔalgR strain produced lesser biofilm than did wild-type strain,...
Abstract Pseudomonas aeruginosa is an opportunistic pathogen capable of group behaviors including swarming motility and biofilm formation. Swarming plays important role in the bacterium's spread to new environments, attachment surfaces, Bacterial associated with many persistent infections increased resistance antibiotics. In this study, we tested effect a 2‐alkyl‐4(1H)‐quinolone (AHQ) signal, quinolone signal (PQS) on P. Our results show that PQS repressed PAO1. Such repression was...
Pseudomonas aeruginosais an opportunistic pathogen that causes serious acute or chronic infections in humans.Acute typically involve the type Ш secretion systems (T3SS) and bacterial motility,whereas infectionsare often associated with biofilm formation VI system (T6SS). To identifynew genes required for pathogenesis, a transposon mutagenesis library was constructed gene PA4857, named tspR, found to modulateT3SS expression. Deletion of P. aeruginosa tspRreduced virulence mouse lung infection...
One of the leading causes morbidity and mortality in cystic fibrosis (CF) patients is pulmonary infection with Pseudomonas aeruginosa, pathophysiology CF affected by lifestyle this micro-organism. RetS-GacS/A-RsmA a key regulatory pathway P. aeruginosa that determines bacterium's choice. Previously, we identified PA1611, hybrid sensor kinase, as new player interacts RetS influences biofilm formation type III secretion system. In study, explored structural mechanistic basis interaction...
Pseudomonas aeruginosa possesses at least three well-defined quorum-sensing (QS) (las, rhl and pqs) systems that control a variety of important functions including virulence. RsaL is QS repressor reduces signal production ensures homeostasis by functioning in opposition to LasR. However, its regulatory role remains elusive. Here, we conducted ChIP-seq assay revealed bound two new targets, the intergenic regions PA2228/PA2229 pqsH/cdpR, which are required for PQS synthesis. Deletion rsaL...
Glutathione is the most abundant antioxidant in all living organisms. We have previously identified a deletion mutant of glutathione synthetase gene (gshB) Pseudomonas aeruginosa caused decreased expression type III secretion system (T3SS), but mechanism remains elusive. In this study, comprehensive transcriptome analysis ΔgshAΔgshB lacking ability to synthesize (GSH) P. was used elucidate role pathogenesis aeruginosa. The result shows that some systems and regulatory genes were impaired,...
Strain sw-1, isolated from 7619-m seawater of the Mariana Trench, was identified as Acinetobacter pittii by 16S rRNA gene and whole-genome sequencing. A. sw-1 able to efficiently utilize long-chain n-alkanes (C18–C36), but not short- medium-chain (C8–C16). The degradation rate C20 91.25%, followed C18, C22, C24, C32, C36 with rates 89.30%, 84.03%, 80.29%, 30.29%, 13.37%, respectively. To investigate mechanisms for this strain, genome transcriptome analyses were performed. Four key alkane...
Hypoxia-inducible factor 1 (HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we constructed a recombinant adeno-associated virus (rAAV) vector expressing the human HIF-1α gene (rAAV-HIF-1α), tested assumption that rAAV-HIF-1α represses hippocampal neuronal protein. Our results confirmed significantly reduces primary cultured Direct intracerebral administration also robust prolonged...
Increasing evidence indicates that disruption of normal iron homeostasis may contribute to pathological development Alzheimer's disease. Icariin, astragalus, and puerarin have been shown suppress overload in the cerebral cortex improve spatial learning memory disorders disease mice, although underlying mechanism remains unclear. In present study, APPswe/PS1ΔE9 transgenic mice were administered icariin, (120, 80, 80 mg/kg, respectively, once a day, for 3 months). Iron levels detected by flame...
Immune cells in the human lung are associated with idiopathic pulmonary fibrosis. However, contribution of different immune cell subpopulations to pathogenesis fibrosis remains unclear. We used single-cell RNA sequencing data investigate transcriptional profiles lungs 5 IPF patients and 3 subjects non-fibrotic lungs. In an identifiable population cells, we found increased percentage CD8+ T subpopulation IPF. Monocle analyzed dynamic status transformation as well cytotoxicity exhausted at...
ABSTRACT Background The malignant features of prostate cancer (PC) threaten the patient's life. MUC1 was observably enhanced in PC. However, reason for higher expression PC is still unclear and deserves to be further investigated. Methods abundance E2F4 evaluated using RT‐qPCR patients cells. Pearson correlation coefficient analyzed relationship between tissues from patients. Malignant phenotypes were examined clone formation, scratch tests, transwell, flow cytometry. JASPAR website,...