A5101998216- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Neuropeptides and Animal Physiology
- Synthetic Organic Chemistry Methods
- Essential Oils and Antimicrobial Activity
- Receptor Mechanisms and Signaling
- Traditional and Medicinal Uses of Annonaceae
- Stress Responses and Cortisol
- Biological Activity of Diterpenoids and Biflavonoids
- interferon and immune responses
- Pineapple and bromelain studies
- Plant Toxicity and Pharmacological Properties
- NF-κB Signaling Pathways
- Phytochemistry and Bioactive Compounds
- Marine Sponges and Natural Products
- Plant and animal studies
- Plant biochemistry and biosynthesis
- Phytochemical Studies and Bioactivities
- Immune Response and Inflammation
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
Affiliated Hospital of Hebei University
2020-2025
Hebei University of Engineering
2024-2025
Hebei University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Hebei Medical University
2007-2021
Baoding University
2021
Yanshan University
2016
Hebei Chemical and Pharmaceutical College
2015
First Hospital of Shijiazhuang
2013
Tohoku University
2011
Abstract Opium poppy ( Papaver somniferum ) is a source of morphine, codeine, and semisynthetic derivatives, including oxycodone naltrexone. Here, we report the de novo assembly genomic analysis P. traditional landrace ‘Chinese Herbal Medicine’. Variations between 2.62 Gb CHM genome that previously sequenced high noscapine 1 (HN1) variety were also explored. Among 79,668 protein-coding genes, functionally annotated 88.9%, compared to 68.8% reported in HN1 genome. Gene family 4DTv comparative...
The neuropeptide cholecystokinin octapeptide (CCK-8) inhibits inflammation by downregulating the expression of proinflammatory cytokines, such as tumor necrosis factor alpha and interleukin (IL) 1beta during endotoxin shock. However, signaling mechanism CCK-8 action has not yet been clearly elucidated. In this study, we have examined possible pathways which lipopolysaccharide (LPS)-induced IL-1beta production in rat pulmonary interstitial macrophages. macrophages, LPS is known to activate...
Abstract TRK-fused gene (TFG) is known to be involved in protein secretion and plays essential roles an antiviral innate immune response. However, its function LPS-induced inflammation pyroptotic cell death still unknown. Here, we reported that TFG promotes the stabilization of Unc-51 like autophagy activating kinase (ULK1) participates LPS plus nigericin (Ng) induced death. Our results showed TFG-deficient THP-1 macrophages exhibit higher mitochondrial ROS production. LPS/Ng stimulation...
3 Eight sesquiterpene lactones were isolated from the roots of Inula helenium and fl owers I. japonica. Among them, isoalantolactone () santamarine ( 6 ) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited lines (IC50 ≤ 100 μM). In addition, significantly tumour S180 tumour-bearing mice. Compounds not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that antitumour are closely related...
Abstract The genus Ajuga , a member of the Lamiaceae family, is comprised more than 300 species annual and perennial herbaceous flowering plants mainly distributed throughout temperate regions Asia, Europe, Australia, North America Africa. These are used as folk medicines effective for rheumatic fevers, dysentery, malaria, hypertension, diabetes gastrointestinal disorders, well anthelmintic, astringent, febrifuge diuretic, antifungal anti-inflammatory agents. A variety constituents has been...
Five new sesquiterpenoids, (4S, 5S, 6S, 7S, 8 R)-5,6-dihydroxy-1-acetoxy-10(14)-en-britannilactone (1), 5 R, (2), 6-O-propionylbritannilactone (3), 1β-hydroxy-3α-acetoxyeudesma-11(13)-en-12,8β-olide (4) and 1β,5β-dihydroxyeudesma-11(13)-en-12,8β-olide (5), along with twelve known ones were isolated from the flowers of Pentanema britannicum (L.) D.Gut.Larr. Among them, compounds 1 2 stereoisomers which belong to 1,10-seco-eudesmane sesquiterpenoid rare double bond between C-10 C-14. The...
From the flowers of Pentanema britannicum (L.) D.Gut.Larr., three new eudesmanolides, britannitin A (1), B (2) and C (3), as well 17 known compounds, were successfully extracted. Compounds 1-3 eudesmane sesquiterpene lactones with a rare -C = C- linking carbons 7 11. Structural determination separated compounds was achieved through range spectroscopic techniques, such 1D 2D NMR analyses. Compound 5β-hydroxyasperilin (HA) demonstrated ability to ameliorate depression-like behaviours in mice...
Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures determined on basis spectroscopic methods. Three them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against human cancer line MCF7WT (IC 50 = 5.51 μm) in vitro.
Abstract Rationale The management of depression continues to be challenging despite the variety available antidepressants. Herbal medicines are used in many cultures but lack stringent testing understand their efficacy and mechanism action. Isoalantolactone (LAT) from Elecampane ( Inula helenium ) improved chronic social defeat stress (CSDS)-induced anhedonia-like phenotype mice comparable fluoxetine, a selective serotonin reuptake inhibitor (SSRI). Objectives Compare effects LAT fluoxetine...
Two new limonoids, named xylomexicanins C and D, were isolated from a dichloromethane extract of the seeds Xylocarpus granatum cultivated in Hainan, China, their structures elucidated on basis one- two-dimensional NMR (including 1H, 13C-NMR, DEPT, 1H-1H COSY, HSQC, HMBC, NOESY) confirmed by high-resolution mass spectrometry. Xylomexicanin exhibited antiproliferative activity against human breast carcinoma cells (KT).
Two tetranortriterpenoids with new skeletons, xylomexicanins I and J (1 2), were isolated during the investigation of chemical constituents from seeds Chinese mangrove, Xylocarpus granatum. Xylomexicanin (1) is an unprecedented limonoid bridged B- C-rings. A biosynthesis pathway for 1 xylomexicanin F proposed.
Interleukin 10(IL-10), as an immunoregulatory cytokine, plays important role in rheumatoid arthritis (RA). IL-10 gene silencing is associated with the chromatin remodeling differentiated Th1 and Th2 cells. To explore relationship between promoter methylation pathogenesis of RA, mRNA, protein expression status were analyzed peripheral blood mononuclear cells (PBMC) 34 RA patients 30 healthy controls by reverse transcriptase-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay...
Abstract Background Prolonged forced abstinence from morphine can increase cue-induced cravings for the drug, contributing to a persistent vulnerability relapse. Previous studies have identified implications of aberrant microRNA (miRNA) regulation in pathogenesis addiction, but changes miRNA expression during incubation craving are still unknown. Methods Nucleus accumbens (NAc)-specific altered transcriptomics was determined mouse model following next-generation sequencing method and...
Abstract Background Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate precise effect and role cholecystokinin (CCK) 1 and/or 2 receptors in dependence, a SH-SY5Y cell model was employed, which μ-opioid receptor, CCK1/2 receptors, CCK are co-expressed. Results Forty-eight hours after...
Cholecystokinin octapeptide (CCK-8), a gut-brain peptide, regulates variety of physiological behavioral processes. Previously, we reported that exogenous CCK-8 attenuated morphine-induced conditioned place preference, but the possible effects on aversively motivated drug seeking remained unclear. To investigate endogenous and CCK negative components morphine withdrawal, evaluated receptor antagonists naloxone-precipitated withdrawal-induced aversion (CPA). The results showed CCK2 antagonist...