A5063939423- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational exposure and asthma
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Energy and Environment Impacts
- Welding Techniques and Residual Stresses
- Gold and Silver Nanoparticles Synthesis and Applications
- High-Temperature Coating Behaviors
- Photoacoustic and Ultrasonic Imaging
- Heavy metals in environment
- Cancer Cells and Metastasis
- Additive Manufacturing Materials and Processes
- Luminescence Properties of Advanced Materials
- Antimicrobial agents and applications
Qingdao University
2018-2025
Qingdao Women and Children's Hospital
2024-2025
Tianjin University
2025
National Institutes for Food and Drug Control
2008-2024
Affiliated Hospital of Qingdao University
2024
Second Affiliated Hospital of Zhejiang University
2018-2023
National Center for Nanoscience and Technology
2014-2020
University of Occupational and Environmental Health Japan
2020
University of Chinese Academy of Sciences
2016-2017
Chinese Academy of Sciences
2015-2016
Silver nanoparticles (SNPs) are widely used in the field of biomedicine, but a comprehensive understanding how SNPs distribute body and induced toxicity remains largely unknown. The present study was designed to investigate distribution accumulation rats with subcutaneous injection. Rats were injected either or silver microparticles (SMPs) at 62.8 mg/kg, then sacrificed predetermined time points. main organs experimental animals harvested for ultrastructural analysis by transmission electron...
Core–shell upconversion [email protected]–organic framework ([email protected]) nanostructures are constructed by coating hexagonal NaYF4:Yb,Er nanoparticle (NP) cores with amino-functionalized iron carboxylate MOF shells. These combine the near-infrared optical property of UCNP and T2-magnetic response (MR) imaging After surface modification, core–shell demonstrated as high-resolution nanoprobes for targeted luminescence/MR both in vitro vivo. As a service to our authors readers, this...
To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes NPs. However, a grand challenge capture high-resolution image metallic NPs in single cell and information on Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) SR-X-ray absorption near edge structure (SR-XANES) spectroscopy, we successfully 3D distribution silver (AgNPs) inside human monocyte...
Abstract The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C 82 (OH) 22 , while essentially not toxic normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cells. blocks epithelial-to-mesenchymal transition with resultant efficient elimination stem cells (CSCs) resulting in...
A key challenge for the use of inorganic nanomedicines in clinical applications is their long-term accumulation internal organs, which raises common concern risk adverse effects and inflammatory responses. It thus necessary to rationally design nanomaterials with proper clearance mechanism vivo. Herein, we prepared ultrasmall Cu3BiS3 nanodots (NDs) as a single-phased ternary bimetal sulfide photothermal cancer therapy guided by multispectral optoacoustic tomography (MSOT) X-ray computed (CT)...
Tire wear microplastic particles (TWMPs) are emerging pollutants that have gained increasing attention lately. However, the health effect of inhaled airborne TWMPs has never been explored before and may already be included in particulate matter morbidity mortality. Here, we endeavored to address preliminary study TWMP inhalation-induced pulmonary toxic effects its epigenetic mechanisms C57BL/6 mice. As a result, restricted ventilatory dysfunction fibrotic pathological changes were observed...
Upconversion (UC) luminescent lanthanide nanoparticles (LNPs) are expected to play an important role in imaging and photodynamic therapy (PDT) vitro vivo. However, with the absorption of UC emissions by photosensitizers (PSs) generate singlet oxygen ((1)O2) for PDT, signals from LNPs significantly weakened. It is activate another route track location during PDT process. In this work, Nd(3+)-sensitized dual-band visible near-infrared (NIR) under single 808 nm excitation were reported address...
Cancer stem cells (CSCs) have the ability to transform into bulk cancer cells, promote tumor growth and establish metastasis. To effectively inhibit prevent metastasis, treatments with conventional chemotherapy drugs should be combined CSC targeted drugs. In this study, we describe synthesis characterization of a new amphiphilic polymer, hyaluronic acid-cystamine-polylactic-co-glycolic acid (HA-SS-PLGA), composed hydrophobic PLGA head hydrophilic HA segment linked by bioreducible disulfide...
Silver nanoparticles (SNPs) translocate to the brain through blood stream after they are implanted in vivo. The aim of this study was investigate distribution SNPs that crossed blood-brain barrier (BBB). An vitro BBB model established by co-cultures rat microvessel vascular endothelial cells (BMVECs) with astrocytes (ACs) cultured cell culture medium containing 100 microg/mL either or silver microparticles (SMPs). After 4 hours culture, ultrastructure and its content evaluated transmission...
Magnetic resonance imaging contrast agents with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, but have rarely been reported. Herein, we present a simple strategy to improve by introducing surface ligands strong interaction water molecules. As proof concept, NaGdF4 nanoparticles (NPs) capped poly(acrylic acid) (PAA) show superior those polyethylenimine polyethylene glycol, which is attributed the hydrogen-bond capacity...
Biofilms significantly impede the efficacy of conventional antimicrobial agents, particularly in multidrug-resistant (MDR) infections. In this work, we developed a size-adaptive, bismuth-based nanomicrobicide encapsulated with neutrophil membranes (Bi2S3/SNP@CM), designed to selectively generate nitric oxide (NO) within acidic biofilms under near-infrared (NIR) irradiation. The nanomicrobicide's adaptive size ensures deeper biofilm penetration and accumulation, while membrane coating...
Nowadays, more and nanotechnology products nanomaterials are being applied in our lives. Silver nanoparticles (SNPs) used infection prevention treatment due to their antimicrobial activity. However, as a kind of nanomaterial, the toxicology SNPs has not been completely studied. The mechanism cytotoxicity vitro mouse's fibroblast cells (L929) was investigated this study. As contrast, silver microparticles (SMPs) were also Propidium iodide (PI) single staining Annexin-V/PI carried out unveil...
Due to aspect ratio dependent localized surface plasmon resonance (SPR), gold nanorods (Au NRs) can be tuned have a strong absorption in the near infrared region (NIR) and convert light heat energy, which shows promises cancer photothermal therapy. In this study, we introduced another more efficient NIR agent, Au coated with shell of Pt nanodots (Au@Pt nanostructures). After modification dots, Au@Pt nanostructure became therapy agent as verified both vitro vivo. To clarify mechanism,...
Establishment of analytical methods engineered nanomaterials in consumer products for their human and environmental risk assessment becomes urgent both academic industrial needs. Owing to the difficulties challenges around complex media, proper chemical separation biological assays from nanoproducts needs be firstly developed. Herein, a facile rapid method separate analyze gold cosmetics is reported. Gold are successfully separated different facial or eye creams physiochemical properties...