A5101720441- Pluripotent Stem Cells Research
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- TGF-β signaling in diseases
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- RNA regulation and disease
- Cancer Cells and Metastasis
- Zebrafish Biomedical Research Applications
- Circular RNAs in diseases
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Immune responses and vaccinations
- Kruppel-like factors research
- Alkaline Phosphatase Research Studies
- Mechanisms of cancer metastasis
Stem Cell Institute
2024
Wellcome/MRC Cambridge Stem Cell Institute
2024
Huizhou Central People's Hospital
2021-2024
Temple University
2016-2024
Women's Hospital, School of Medicine, Zhejiang University
2020-2023
Tianjin Medical University Cancer Institute and Hospital
2016-2020
Zhejiang University
2019
First Bethune Hospital of Jilin University
2018
First Hospital of Jilin University
2018
Jilin University
2018
A Fix to the Heart Regenerative cardiovascular medicine is a promising avenue for therapeutic application in advanced heart failure. Although clinical trials have suggested some limited benefits cell transplantation therapy, robust cardiac muscle formation lacking. Domian et al. (p. 426 ) examined developmental processes normal mature muscle. two-color murine reporter system was used isolate committed ventricular progenitors, which were then build functional force-generating tissue. Such...
Abstract The molecular mechanisms that regulate human blood vessel formation during early development are largely unknown. Here we used ESCs (hESCs) as an in vitro model to explore vasculogenesis. We demonstrated stromal cell-derived factor-1 (SDF-1) and CXCR4 were expressed concurrently with hESC-derived embryonic endothelial differentiation. Human ESC-derived cells underwent dose-dependent chemotaxis SDF-1, which enhanced vascular network Matrigel. Blocking of signaling abolished...
Aquaporin1 (AQP1) belongs to a highly conserved family of aquaporin proteins which facilitate water flux across cell membranes. Although emerging evidences indicated the cytoplasm was important for AQP1 localization, function corresponding its cytoplasmic distribution has rarely been explored until present. In our clinical study, we reported first time that localized dominantly in cancer cells invasive breast patients and an independent prognostic factor. High expression shorter survival,...
Abstract Anthracyclines are a class of conventional and commonly used frontline chemotherapy drugs to treat breast cancer. However, the anthracycline-based regimens can only reduce cancer mortality by 20–30%. Furthermore, there is no appropriate biomarker for predicting responses this kind currently. Here we report our findings that may fill gap showing AQP1 (Aquaporin1) protein as potential response predictor in anthracycline chemotherapy. We showed patients with high level expression who...
Intersectin1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which is highly regulated by alternative splicing. However, the alteration of splicing its importance in cancer still unknown. In this study, our transcriptome analysis using a large glioma cohort indicated isoforms exerted opposite function progression. Our previous results had shown could promote development; however, ITSN1-L remained we first confirmed that an inhibitory role progression both vivo vitro, was contrary to...
Despite the interest in mesenchymal stem cells (MSC), their potential to treat abnormal scarring, especially keloids, is yet be described. The present study aimed investigate therapeutic of exosomes derived from human bone marrow MSCs (hBMSC-Exos) alleviating keloid formation.
ABSTRACT Postmenopausal osteoporosis (PMOP)‐related fractures usually result in morbidity and mortality aging women, so it remains a global public health concern, new effective safe treatments are urgently needed recently. Efficient osteogenesis from mesenchymal stem cells (MSCs) would have the clinical application potential treating multiple osteal disorders. Follicle‐stimulating hormone (FSH), pituitary glycoprotein highly associated with menopausal bone turnover, whose peculiar part of...
Rosiglitazone (RSG) is a potent drug used in the treatment of insulin resistance; however, it associated with marked skeletal toxicity. RSG-induced osteoporosis may contribute to promotion adipogenic differentiation at expense osteogenic bone marrow stromal cells. The aim this study was investigate whether toxicity can be reversed by combined all-trans retinoic acid (ATRA). We examined different markers mouse embryonic fibroblasts (MEFs) following RSG, ATRA, or RSG and ATRA combination....
Acrylamide (ACR), formed during the Maillard reaction induced by high temperature in food processing, is one of main causes neurodegenerative diseases. Taurine, a free intracellular β-amino acid, characterized many functions, including antioxidation, anti-inflammatory, and neuroprotective properties. This promotes its application treatment In this study, effects taurine against ACR-induced neurotoxicity potential underlying mechanisms were explored. Rats intoxicated with ACR injected...
Anterior gradient 3 (AGR3) belongs to human anterior (AGR) family. The function of AGR3 on cancer remains unknown. This research aimed investigate if had prognostic values in invasive ductal carcinoma (IDC) breast and could promote tumor progression.AGR3 expression was detected benign lesions, situ IDC by immunohistochemistry analysis. AGR3's correlations with clinicopathological features prognosis patients were analyzed. By cell experiments, collagen gel droplet-embedded culture drug...
Girdin is an actin-binding protein playing key roles in the development of various carcinomas. Although online tools have predicted nuclear localization girdin with a high probability, convincing proof has rarely been provided until now. The purpose this study was to discover girdin's precise subcellular distribution and potential prognostic value corresponding its localization. detected human breast cancer cell line >800 samples tissue by clinical pathologic analysis. In study, we...
To explore the expression, localization and regulatory effect on mitochondrial calcium signaling of Rictor in embryonic stem cell-derived cardiomyocytes (ESC-CMs).Classical cell cardiomyogenesis model was used for differentiation mouse cells into cardiomyocytes. The location ESC-CMs investigated by immunofluorescence Western blot. expression interfered with lentiviral technology, then superposition mitochondria endoplasmic reticulum (ER) detected method; cellular ultrastructure observed...
Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms with Brain Iron Accumulation, caused by mutations in gene encoding autophagy-related protein, WDR45. The mechanisms linking autophagy, iron overload and neurodegeneration BPAN are poorly understood and, as a result, there currently no disease-modifying treatments for this progressive disorder. We have developed patient-derived, induced pluripotent stem cell (iPSC)-based midbrain dopaminergic neuronal...