A5014201876- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Estrogen and related hormone effects
- Inhalation and Respiratory Drug Delivery
- Immunotoxicology and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Neonatal and fetal brain pathology
- Climate Change and Health Impacts
- MicroRNA in disease regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microplastics and Plastic Pollution
- Neurogenesis and neuroplasticity mechanisms
- Animal testing and alternatives
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Environmental Chemistry and Analysis
- Carbon dioxide utilization in catalysis
- Occupational exposure and asthma
- Pregnancy-related medical research
- Thermal Regulation in Medicine
- Air Quality Monitoring and Forecasting
- Steroid Chemistry and Biochemistry
- Refrigeration and Air Conditioning Technologies
Qingdao University
2010-2024
Research Center for Eco-Environmental Sciences
2017-2021
Chinese Academy of Sciences
2017-2021
University of Chinese Academy of Sciences
2017-2021
Institute of Coal Chemistry
2021
Beijing University of Technology
2021
Emory University
2014-2015
Tire wear microplastic particles (TWMPs) are emerging pollutants that have gained increasing attention lately. However, the health effect of inhaled airborne TWMPs has never been explored before and may already be included in particulate matter morbidity mortality. Here, we endeavored to address preliminary study TWMP inhalation-induced pulmonary toxic effects its epigenetic mechanisms C57BL/6 mice. As a result, restricted ventilatory dysfunction fibrotic pathological changes were observed...
Abstract Introduction Poor cell survival and limited functional benefits have restricted the efficacy of bone marrow mesenchymal stem cells (BMSCs) in treatment myocardial infarction. We showed recently that hypoxia preconditioning BMSCs neural progenitor before transplantation can enhance therapeutic properties these ischemic brain heart. The present investigation explores a novel strategy using Hypoxia-inducible factor 1α (HIF-α) prolyl hydroxylase inhibitor dimethyloxalylglycine (DMOG) to...
Neonatal stroke is a major cause of mortality and long-term morbidity in infants children. Currently, very limited therapeutic strategies are available to protect the developing brain against ischemic damage promote repairs for pediatric patients. Moreover, children who experienced neonatal often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as regenerative after stroke. In present investigation, postnatal day 7...
Three-dimensional (3D) structured organoids have become increasingly promising and effective in vitro models, there is an urgent need for reliable models to assess health effects of inhaled pollutants on the human airway. In our study, we conducted a toxicity assessment airway (hAOs) tire wear particles (TWPs) as emerging pollutant. We induced primary bronchial epithelial cells (HBECs) generated organoids, which recapitulated key features including basal cells, ciliated goblet club cells....
Background Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. Moreover, BPA frequently used in food contact materials, has been extensively researched recently, widespread exposure the general population reported worldwide. However, national information on levels Chinese people lacking. Methods This study collected analyzed 145 (104 urine 41 serum) research articles published between 2004 2021 to reflect internal...
The activation of nuclear factor-κB (NF-κB) has been implicated in the development and progression endometriosis. aim this study is to investigate potential application pyrrolidine dithiocarbamate (PDTC), a potent NF-κB inhibitor, treatment NF-κB-DNA-binding activity, IκB phosphorylation expression p65 protein endometriotic ectopic stromal cells (EcSCs), eutopic (EuSCs) normal endometrial (NESCs) were detected by electrophoretic mobility shift assay western blot analysis. Adhesion,...
Phenanthrene (Phe) is one of the most abundant low-molecular-weight polycyclic aromatic hydrocarbons (PAHs). Widespread human and aquatic organism exposure to Phe has been reported, but toxic effects potential mechanisms are unclear. We focused on chronic hepatotoxicity in adult Chinese rare minnows (Gobiocypris rarus) underlying mechanisms. The exposing 8.9, 82.3, or 510.0 μg/L for 30 days were examined by histopathological observation, TUNEL assays, caspase activity gene expression...
As the typical aryl-organophosphate flame retardants (OPFRs), triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) (TDCIPP) were reported to be estrogen disruptors. However, receptor α (ERα) binding experiments could not explain their biological effects. In this study, action on ERα, G protein-coupled (GPER) synthesis of 17β-estradiol (E2) investigated using in vitro assays molecular docking. The results showed that TPhP acted as an ERα agonist recruited steroid co-activator 1 (SRC1) 3...
Cadmium (Cd), a ubiquitous heavy metal, exists in numerous environmental matrices and has severe adverse effects on various human organs tissues. This research evaluates blood urine Cd levels the Chinese population through data mining using Monte Carlo simulation (MCS). A total of 168 scientific studies (120 48 blood) published between January 1980 December 2020, reflecting 109,743 individuals China, were included study. The results indicate that exhibited peak from 1990 to 1995 remained...
Abstract Background Chronic exposure to diesel exhaust has a causal link cardiovascular diseases in various environmental and occupational settings. Arterial endothelial cell function plays an important role ensuring proper maintenance of homeostasis the dysfunction by circulatory inflammation is hallmark diseases. Acute controlled studies leads artery cells previous study, however effect chronic remains unknown. Results We applied ex vivo biosensor assay for serum samples from 133 engine...
Inhaling polyhexamethylene guanidine (PHMG) aerosol, a broad-spectrum disinfectant, can lead to severe pulmonary fibrosis. Ferroptosis, form of programmed cell death triggered by iron-dependent lipid peroxidation, is believed play role in the chemical-induced injury. This study aimed investigate mechanism ferroptosis progression PHMG-induced C57BL/6 J mice and alveolar type II line MLE-12 were used evaluate toxicity PHMG vivo vitro, respectively. The findings indicated that iron deposition...
Polyhexamethylene guanidine (PHMG) is manufactured and applied extensively due to its superior disinfectant capabilities. However, the inhalatory exposure PHMG aerosols increasingly recognized as a potential instigator of pulmonary fibrosis, prompting an urgent call for elucidation underlying pathophysiological mechanisms. Within this context, alveolar macrophages play pivotal role in primary immune defense respiratory tract. Dysregulated lipid metabolism within leads accumulation foam...