A5005024003- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Climate Change and Health Impacts
- Glutathione Transferases and Polymorphisms
- Air Quality Monitoring and Forecasting
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Energy and Environment Impacts
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Health, Environment, Cognitive Aging
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Toxic Organic Pollutants Impact
- Occupational and environmental lung diseases
- Lung Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Genetically Modified Organisms Research
- Indoor Air Quality and Microbial Exposure
- Effects and risks of endocrine disrupting chemicals
- Occupational exposure and asthma
- Contact Dermatitis and Allergies
University of New Mexico
2020-2025
UNM Comprehensive Cancer Center
2020-2023
New Mexico Cancer Center
2020-2023
Qingdao University
2017-2022
University of Occupational and Environmental Health Japan
2020
Lovelace Respiratory Research Institute
2017
National Institute for Occupational Health and Poison Control
2003-2011
Center for Disease Control
2009
Sun Yat-sen University
2009
Chinese Center For Disease Control and Prevention
2005
Oxidative stress has been suggested to be one of the key drivers health impact particulate matter (PM). More studies on oxidative potential PM alone, but fewer have comprehensively evaluated effects external and internal exposure compositions in population. To investigate exposure–response relationship between its main with indicators. We conducted a cross-sectional study including 768 participants exposed particulates. Environmental levels fine (PM2.5), polycyclic aromatic hydrocarbons...
BackgroundTrichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized one of the major environmental pollutants. To date, > 200 cases TCE-induced hypersensitivity dermatitis among exposed workers have reported worldwide, TCE exposure become critical occupational health issues in Asia.ObjectivesThe study aimed to identify genetic susceptible biomarkers associated with genes located human leukocyte antigen (HLA) region.MethodsFrom 1998 2006, 121 142 tolerant...
Abstract Exploring the associations between genetic polymorphisms of metabolic enzymes and susceptibility to polycyclic aromatic hydrocarbon (PAH)–induced chromosomal damage is great significance for understanding PAH carcinogenesis. Cytochrome P450, glutathione S-transferase, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, N-acetyltransferase are PAH-metabolizing enzymes. In this study, we genotyped these genes assessed their effects on cytokinesis-block micronucleus (CBMN)...
Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease exposed populations. An endothelial biosensor assay was used to quantify capacity of sera from 82 packers (CBP) 106 non-CBPs induce cell activation ex vivo. The mediation effect circulatory proinflammatory factors on association between exposure further...
Second-hand smoke (SHS) exposure during pregnancy is common and may negatively impact maternal mental health. Recent evidence on the association between SHS depression remains inconsistent. This study aims to examine longitudinal depression. A prospective birth cohort study. From October 2017 September 2021, we conducted a including 5311 pregnant women. We applied mixed-effects models group-based multivariate trajectory modeling estimate pregnancy. The prevalence of was 40.61 %, 19.00 20.35...
Diesel exhaust (DE) as the major source of vehicle-emitted particle matter in ambient air impairs lung function. The objectives were to assess contribution local (eg, fraction exhaled nitric oxide [FeNO] and serum Club cell secretory protein [CC16]) systemic C-reaction [CRP] interleukin-6 [IL-6]) inflammation DE-induced function impairment using a unique cohort diesel engine testers (DETs, n = 137) non-DETs (n 127), made up current noncurrent smokers. Urinary metabolites, FeNO, markers,...
Abstract Background Pneumonia is one of the principal reasons for incidence and death in world. The former research mainly concentrated on specific sources patients. Besides, due to heterogeneity among regions, there are inconsistencies outcome these surveys. To explore relationship between atmospheric pollution hospital visits pneumonia under climate conditions Qingdao, we carried out this study. Methods medical records patients were gathered from affiliated Qingdao University during Jan...
Abstract Theoretically, a haplotype has higher level of heterozygosity than individual single nucleotide polymorphism (SNP) and the association study based on may have an increased power for detecting disease associations compared with SNP-based analysis. In this study, we investigated effects four haplotype-tagging SNPs (htSNP) inferred pairs X-ray cross-complementing group 1 (XRCC1) gene chromosome damage detected by cytokinesis-block micronucleus assay. The included 141 coke-oven workers...
Abstract Background Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in ambient air and contaminates many occupational settings. Airway remodeling assessed using computerized tomography (CT) correlates well with spirometry patients obstructive lung diseases. Structural changes small airways caused by chronic DE exposure unknown. Wall lumen areas 6th 9th generations four candidate were quantified end-inhalation CT scans 78 diesel engine testers (DET) 76 non-DETs....
Abstract Many host factors or biomarkers are involved in the process of early DNA damage induced by occupational exposure to polycyclic aromatic hydrocarbons (PAH) as seen coke-oven workers. This paper aimed identify complicated causal interrelationship various using path analysis. In this analysis, we included 235 subjects (166 workers and 69 nonexposed controls) whose data on comet assay (e.g., Olive tail moment) cytogenetic analysis peripheral blood lymphocytes well urinary...
Nanoscale carbon black as virtually pure elemental can deposit deep in the lungs and cause pulmonary injury. Airway remodeling assessed using computed tomography (CT) correlates well with spirometry patients obstructive lung diseases. Structural airway changes caused by exposure remain unknown. Wall lumen areas of sixth ninth generations airways 4 lobes were quantified end-inhalation CT scans 58 current packers (CBPs) 95 non-CBPs. Carbon content macrophage (CCAM) sputum was to assess...
Iron and steel industry workers are exposed to high levels of inhalable dust particles that contain various elements, including metals, cause occupational lung diseases. We aim assess the relationship between exposure, systemic inflammation, spirometric decline in a cohort Chinese iron workers.We studied 7513 who participated Health Surveillance program at Wugang Institute for Occupational 2008 2017. Time-weighted exposure intensity (TWEI) was quantified based on self-reported history,...
Trichloroethylene (TCE)-induced severe generalized dermatitis (SGD) is considered to be a contact allergic disease and dependent on cell-mediated immune response. Little known about its pathogenesis. Several lines of evidence suggest that tumour necrosis factor (TNF) interleukin 4 (IL-4) are involved in the immunological inflammatory reactions. To investigate relation between polymorphisms TNF IL-4 gene risk TCE-induced SGD, case-control study was conducted consisting 111 patients diagnosed...
A wide variety of base damages and single-strand breaks formed by reactive oxygen species during metabolic activation polycyclic aromatic hydrocarbons (PAHs) have been recognized to be involved in PAH carcinogenesis. In this study, alkaline comet assay was used detect the DNA damage peripheral blood lymphocytes among 143 coke-oven workers 50 non-coke-oven workers, effects genetic polymorphisms XRCC1 ERCC2 genes on were evaluated. The olive tail moment significantly higher than (2.6, 95%...
Abstract Background Chronic exposure to diesel exhaust has a causal link cardiovascular diseases in various environmental and occupational settings. Arterial endothelial cell function plays an important role ensuring proper maintenance of homeostasis the dysfunction by circulatory inflammation is hallmark diseases. Acute controlled studies leads artery cells previous study, however effect chronic remains unknown. Results We applied ex vivo biosensor assay for serum samples from 133 engine...